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| author | root | 2012-05-08 18:39:56 -0500 |
|---|---|---|
| committer | root | 2012-05-08 18:39:56 -0500 |
| commit | ea46f42ee640928b92947bfb204c41a482d80937 (patch) | |
| tree | 9b27a4eb852d12539b543c3efee9d2a47ef470f3 /web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0011.htm | |
| parent | 056b5253fc3857b0444382aa39944f6344dc1ceb (diff) | |
| download | genenetwork2-ea46f42ee640928b92947bfb204c41a482d80937.tar.gz | |
Add all the source codes into the github.
Diffstat (limited to 'web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0011.htm')
| -rwxr-xr-x | web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0011.htm | 25 |
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diff --git a/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0011.htm b/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0011.htm new file mode 100755 index 00000000..dd8304f8 --- /dev/null +++ b/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0011.htm @@ -0,0 +1,25 @@ +<html>
<head>
<meta http-equiv=Content-Type content="text/html; charset=macintosh">
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<meta name=Generator content="Microsoft Macintosh PowerPoint 11">
<link id=Main-File rel=Main-File href="webqtl_demo2.ppt.htm">
<title>PowerPoint Presentation - Complex trait analysis, develop-ment, and
genomics</title>
<link title="Presentation File" type="application/powerpoint" rel=alternate
href="webqtl_demo2.ppt.ppt">
<script> +if ( ! top.PPTPRESENTATION ) { + window.location.replace( "endshow.htm" ); +} +</script>
<meta name=Description
content="Aug-15-05: Evaluating Ctbp2 using other resources">
<link rel=Stylesheet href="master03_stylesheet.css">
<style media=print>
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<script language=JavaScript src=script.js></script><script language=JavaScript><!--
+gId="slide0011.htm" +if ( !parent.base.g_done && (parent.base.msie < 0 ) ) { + parent.base.g_done = 1; + document.location.replace( parent.base.GetHrefObj(parent.base.g_currentSlide).m_slideHref); +} +if( !IsNts() ) Redirect( "PPTSld", gId ); +var g_hasTrans = true, g_autoTrans = false, g_transSecs = 1; +//-->
+</script><script for=window event=onload language=JavaScript><!--
+if( !IsSldOrNts() ) return; +if( MakeNotesVis() ) return; +LoadSld( gId ); +playList();MakeSldVis(1); +//-->
+</script>
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<body style='margin:0px;background-color:black' onclick="DocumentOnClick(event)"
onresize="_RSW()" onkeypress="_KPH(event)">
<div id=SlideObj class=sld style='position:absolute;top:0px;left:0px;
width:755px;height:566px;font-size:16px;background-color:#484848;clip:rect(0%, 101%, 101%, 0%);
visibility:hidden'><img src="master03_background.png" v:shapes="_x0000_s1026"
style='position:absolute;top:0%;left:0%;width:100.0%;height:100.0%'>
<div style='position:absolute;top:0%;left:1.72%;width:101.05%;height:8.65%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
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mso-text-indent-alt:0;position:absolute;top:18.36%;left:.91%;width:97.9%;
height:75.51%'><span style='font-family:Verdana;font-size:64%'>Evaluating </span><span
style='font-family:Verdana;font-size:64%'><i>Ctbp2</i></span><span
style='font-family:Verdana;font-size:64%'> using other resources</span><span
style='font-family:Verdana;font-size:73%;mso-special-format:lastCR;display:
none'><i><br>
</i></span></div>
</div>
<img border=0 src="slide0011_image087.png" style='position:absolute;top:10.07%;
left:1.72%;width:48.21%;height:53.35%'><img border=0
src="slide0011_image088.png" style='position:absolute;top:40.81%;left:19.2%;
width:78.54%;height:54.77%'></div>
<div id=NotesObj style='display:none'>
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<td align=left colspan=1><font face=Verdana size=3>Ctbp2 should also be
considered a high priority biological candidate gene responsible for
modulating App expression levels. The C-terminal binding protein 2 is a
transcriptional co-repressor also known as Ribeye.</font><font
face=Times-Roman size=3> The gene produces two transcripts encoding distinct
proteins. The short form is a transcriptional repressor that binds a
Pro-X-Asp-Leu-Ser peptide motif and interacts with several transcription
factors including EVI1, ZFPM1, and ZFHX1A (aka TCF8, deltaEF1). The longer
isoform is a major component of specialized synapses in photoreceptors. Both
proteins contain a NAD+ binding domain similar to NAD+-dependent
2-hydroxyacid dehydrogenases.</font><br>
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<td align=left colspan=1><font face=Verdana size=3>Notes:</font><br>
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<td align=left colspan=1><font face=Verdana size=3>1. To find out more about
CTBP2 protein and the Ctbp2 gene, link to iHOP at
http://www.pdg.cnb.uam.es/UniPub/iHOP/ and type in CTBP2</font><br>
</td>
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<td align=left colspan=1><font face=Verdana size=3>Try Arrowsmith at
http://arrowsmith.psych.uic.edu/cgi-test/arrowsmith_uic/pubsmith.cgi</font><br>
</td>
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<td align=left colspan=1><font face=Verdana size=3>2. Both APP and CTBP2 are
involved in oxidoreducatase activity or Notch signaling. To establish this
common gene ontology visit NCBI<span style="mso-spacerun: yes">
</span>http://www.ncbi.nih.gov/entrez/query.fcgi?db=gene and enter each gene
symbol.</font><br>
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<td align=left colspan=1><font face=Verdana size=3>3. You can get interesting
hints regarding Ctbp2 expression partners by examining the genetic
correlations between Ctbp2 probe set 1422887_a_at and all other transcripts
on the M430 Affymetrix array. Use the Striatum data set because we already
know from previous work (the previous slide) that this gene is a cis
QTL.<span style="mso-spacerun: yes"> </span>You should be able to show
that Ctbp2 and Notch3 have antagonistic expression patterns in striatum. The
negative genetic correlation with E2f4 is even stronger. The transcript also
has a high positive genetic correlation with Rdh14. Of particular interest
with respect to APP protein processing, Ctbp2 covaries positively with Bace2
(the transcript of the beta site APP-cleaving enzyme 2).</font><br>
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</div>
<script language=JavaScript><!--
+function playList() { + +} +//-->
+</script>
</body>
</html>
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