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+<title>PowerPoint Presentation  -  Complex trait analysis, develop-ment, and
+genomics</title>
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+<meta name=Description
+content="Aug-15-05: Evaluating Ctbp2 using other resources">
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+mso-text-indent-alt:0;position:absolute;top:18.36%;left:.91%;width:97.9%;
+height:75.51%'><span style='font-family:Verdana;font-size:64%'>Evaluating </span><span
+style='font-family:Verdana;font-size:64%'><i>Ctbp2</i></span><span
+style='font-family:Verdana;font-size:64%'> using other resources</span><span
+style='font-family:Verdana;font-size:73%;mso-special-format:lastCR;display:
+none'><i><br>
+</i></span></div>
+</div>
+<img border=0 src="slide0011_image087.png" style='position:absolute;top:10.07%;
+left:1.72%;width:48.21%;height:53.35%'><img border=0
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+<div id=NotesObj style='display:none'>
+<table style='color:white' border=0 width="100%">
+ <tr>
+  <td width=5 nowrap></td>
+  <td width="100%"></td>
+ </tr>
+ <tr>
+  <td colspan=1></td>
+  <td align=left colspan=1><font face=Verdana size=3>Ctbp2 should also be
+  considered a high priority biological candidate gene responsible for
+  modulating App expression levels. The C-terminal binding protein 2 is a
+  transcriptional co-repressor also known as Ribeye.</font><font
+  face=Times-Roman size=3> The gene produces two transcripts encoding distinct
+  proteins. The short form is a transcriptional repressor that binds a
+  Pro-X-Asp-Leu-Ser peptide motif and interacts with several transcription
+  factors including EVI1, ZFPM1, and ZFHX1A (aka TCF8, deltaEF1). The longer
+  isoform is a major component of specialized synapses in photoreceptors. Both
+  proteins contain a NAD+ binding domain similar to NAD+-dependent
+  2-hydroxyacid dehydrogenases.</font><br>
+  </td>
+ </tr>
+ <tr>
+  <td colspan=1></td>
+  <td align=left colspan=1><br>
+  </td>
+ </tr>
+ <tr>
+  <td colspan=1></td>
+  <td align=left colspan=1><font face=Verdana size=3>Notes:</font><br>
+  </td>
+ </tr>
+ <tr>
+  <td colspan=1></td>
+  <td align=left colspan=1><font face=Verdana size=3>1. To find out more about
+  CTBP2 protein and the Ctbp2 gene, link to iHOP at
+  http://www.pdg.cnb.uam.es/UniPub/iHOP/ and type in CTBP2</font><br>
+  </td>
+ </tr>
+ <tr>
+  <td colspan=1></td>
+  <td align=left colspan=1><font face=Verdana size=3>Try Arrowsmith at
+  http://arrowsmith.psych.uic.edu/cgi-test/arrowsmith_uic/pubsmith.cgi</font><br>
+  </td>
+ </tr>
+ <tr>
+  <td colspan=1></td>
+  <td align=left colspan=1><font face=Verdana size=3>2. Both APP and CTBP2 are
+  involved in oxidoreducatase activity or Notch signaling. To establish this
+  common gene ontology visit NCBI<span style="mso-spacerun: yes">&nbsp;
+  </span>http://www.ncbi.nih.gov/entrez/query.fcgi?db=gene and enter each gene
+  symbol.</font><br>
+  </td>
+ </tr>
+ <tr>
+  <td colspan=1></td>
+  <td align=left colspan=1><font face=Verdana size=3>3. You can get interesting
+  hints regarding Ctbp2 expression partners by examining the genetic
+  correlations between Ctbp2 probe set 1422887_a_at and all other transcripts
+  on the M430 Affymetrix array. Use the Striatum data set because we already
+  know from previous work (the previous slide) that this gene is a cis
+  QTL.<span style="mso-spacerun: yes">&nbsp; </span>You should be able to show
+  that Ctbp2 and Notch3 have antagonistic expression patterns in striatum. The
+  negative genetic correlation with E2f4 is even stronger. The transcript also
+  has a high positive genetic correlation with Rdh14. Of particular interest
+  with respect to APP protein processing, Ctbp2 covaries positively with Bace2
+  (the transcript of the beta site APP-cleaving enzyme 2).</font><br>
+  </td>
+ </tr>
+ <tr>
+  <td colspan=1></td>
+  <td align=left colspan=1><br>
+  </td>
+ </tr>
+ <tr>
+  <td colspan=1></td>
+  <td align=left colspan=1><br>
+  </td>
+ </tr>
+</table>
+</div>
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