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+/*
+ Genome-wide Efficient Mixed Model Association (GEMMA)
+ Copyright (C) 2011 Xiang Zhou
+
+ This program is free software: you can redistribute it and/or modify
+ it under the terms of the GNU General Public License as published by
+ the Free Software Foundation, either version 3 of the License, or
+ (at your option) any later version.
+
+ This program is distributed in the hope that it will be useful,
+ but WITHOUT ANY WARRANTY; without even the implied warranty of
+ MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
+ GNU General Public License for more details.
+
+ You should have received a copy of the GNU General Public License
+ along with this program. If not, see <http://www.gnu.org/licenses/>.
+ */
+
+
+#ifndef __BSLMMDAP_H__
+#define __BSLMMDAP_H__
+
+#include <vector>
+#include <map>
+#include <gsl/gsl_rng.h>
+#include <gsl/gsl_randist.h>
+
+#ifdef FORCE_FLOAT
+#include "param_float.h"
+#else
+#include "param.h"
+#endif
+
+
+using namespace std;
+
+
+
+
+
+
+class BSLMMDAP {
+
+public:
+ // IO related parameters
+ int a_mode;
+ size_t d_pace;
+
+ string file_bfile;
+ string file_geno;
+ string file_out;
+ string path_out;
+
+ // LMM related parameters
+ double pve_null;
+ double pheno_mean;
+
+ // BSLMM MCMC related parameters
+ long int randseed;
+ double trace_G;
+
+ HYPBSLMM cHyp_initial;
+
+ // Summary statistics
+ size_t ni_total, ns_total; //number of total individuals and snps
+ size_t ni_test, ns_test; //number of individuals and snps used for analysis
+
+ double h_min, h_max, rho_min, rho_max;
+ size_t h_ngrid, rho_ngrid;
+
+ double time_UtZ;
+ double time_Omega; //time spent on optimization iterations
+ double time_Proposal; //time spent on constructing the proposal distribution for gamma (i.e. lmm or lm analysis)
+ vector<int> indicator_idv; //indicator for individuals (phenotypes), 0 missing, 1 available for analysis
+ vector<int> indicator_snp; //sequence indicator for SNPs: 0 ignored because of (a) maf, (b) miss, (c) non-poly; 1 available for analysis
+
+ vector<SNPINFO> snpInfo; //record SNP information
+
+ // Main Functions
+ void CopyFromParam (PARAM &cPar);
+ void CopyToParam (PARAM &cPar);
+
+ void WriteResult (const gsl_matrix *Hyper, const gsl_matrix *BF);
+ void WriteResult (const vector<string> &vec_rs, const gsl_matrix *Hyper, const gsl_vector *pip, const gsl_vector *coef);
+ double CalcMarginal (const gsl_vector *Uty, const gsl_vector *K_eval, const double sigma_b2, const double tau);
+ double CalcMarginal (const gsl_matrix *UtXgamma, const gsl_vector *Uty, const gsl_vector *K_eval, const double sigma_a2, const double sigma_b2, const double tau);
+ double CalcPrior (class HYPBSLMM &cHyp);
+
+ void DAP_CalcBF (const gsl_matrix *U, const gsl_matrix *UtX, const gsl_vector *Uty, const gsl_vector *K_eval, const gsl_vector *y);
+ void DAP_EstimateHyper (const size_t kc, const size_t kd, const vector<string> &vec_rs, const vector<double> &vec_sa2, const vector<double> &vec_sb2, const vector<double> &wab, const vector<vector<vector<double> > > &BF, gsl_matrix *Ac, gsl_matrix_int *Ad, gsl_vector_int *dlevel);
+
+};
+
+void ReadFile_hyb (const string &file_hyp, vector<double> &vec_sa2, vector<double> &vec_sb2, vector<double> &vec_wab);
+void ReadFile_bf (const string &file_bf, vector<string> &vec_rs, vector<vector<vector<double> > > &BF);
+void ReadFile_cat (const string &file_cat, const vector<string> &vec_rs, gsl_matrix *Ac, gsl_matrix_int *Ad, gsl_vector_int *dlevel, size_t &kc, size_t &kd);
+
+
+#endif
+
+