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Diffstat (limited to 'src/bslmmdap.h')
-rw-r--r-- | src/bslmmdap.h | 101 |
1 files changed, 101 insertions, 0 deletions
diff --git a/src/bslmmdap.h b/src/bslmmdap.h new file mode 100644 index 0000000..ac78f97 --- /dev/null +++ b/src/bslmmdap.h @@ -0,0 +1,101 @@ +/* + Genome-wide Efficient Mixed Model Association (GEMMA) + Copyright (C) 2011 Xiang Zhou + + This program is free software: you can redistribute it and/or modify + it under the terms of the GNU General Public License as published by + the Free Software Foundation, either version 3 of the License, or + (at your option) any later version. + + This program is distributed in the hope that it will be useful, + but WITHOUT ANY WARRANTY; without even the implied warranty of + MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the + GNU General Public License for more details. + + You should have received a copy of the GNU General Public License + along with this program. If not, see <http://www.gnu.org/licenses/>. + */ + + +#ifndef __BSLMMDAP_H__ +#define __BSLMMDAP_H__ + +#include <vector> +#include <map> +#include <gsl/gsl_rng.h> +#include <gsl/gsl_randist.h> + +#ifdef FORCE_FLOAT +#include "param_float.h" +#else +#include "param.h" +#endif + + +using namespace std; + + + + + + +class BSLMMDAP { + +public: + // IO related parameters + int a_mode; + size_t d_pace; + + string file_bfile; + string file_geno; + string file_out; + string path_out; + + // LMM related parameters + double pve_null; + double pheno_mean; + + // BSLMM MCMC related parameters + long int randseed; + double trace_G; + + HYPBSLMM cHyp_initial; + + // Summary statistics + size_t ni_total, ns_total; //number of total individuals and snps + size_t ni_test, ns_test; //number of individuals and snps used for analysis + + double h_min, h_max, rho_min, rho_max; + size_t h_ngrid, rho_ngrid; + + double time_UtZ; + double time_Omega; //time spent on optimization iterations + double time_Proposal; //time spent on constructing the proposal distribution for gamma (i.e. lmm or lm analysis) + vector<int> indicator_idv; //indicator for individuals (phenotypes), 0 missing, 1 available for analysis + vector<int> indicator_snp; //sequence indicator for SNPs: 0 ignored because of (a) maf, (b) miss, (c) non-poly; 1 available for analysis + + vector<SNPINFO> snpInfo; //record SNP information + + // Main Functions + void CopyFromParam (PARAM &cPar); + void CopyToParam (PARAM &cPar); + + void WriteResult (const gsl_matrix *Hyper, const gsl_matrix *BF); + void WriteResult (const vector<string> &vec_rs, const gsl_matrix *Hyper, const gsl_vector *pip, const gsl_vector *coef); + double CalcMarginal (const gsl_vector *Uty, const gsl_vector *K_eval, const double sigma_b2, const double tau); + double CalcMarginal (const gsl_matrix *UtXgamma, const gsl_vector *Uty, const gsl_vector *K_eval, const double sigma_a2, const double sigma_b2, const double tau); + double CalcPrior (class HYPBSLMM &cHyp); + + void DAP_CalcBF (const gsl_matrix *U, const gsl_matrix *UtX, const gsl_vector *Uty, const gsl_vector *K_eval, const gsl_vector *y); + void DAP_EstimateHyper (const size_t kc, const size_t kd, const vector<string> &vec_rs, const vector<double> &vec_sa2, const vector<double> &vec_sb2, const vector<double> &wab, const vector<vector<vector<double> > > &BF, gsl_matrix *Ac, gsl_matrix_int *Ad, gsl_vector_int *dlevel); + +}; + +void ReadFile_hyb (const string &file_hyp, vector<double> &vec_sa2, vector<double> &vec_sb2, vector<double> &vec_wab); +void ReadFile_bf (const string &file_bf, vector<string> &vec_rs, vector<vector<vector<double> > > &BF); +void ReadFile_cat (const string &file_cat, const vector<string> &vec_rs, gsl_matrix *Ac, gsl_matrix_int *Ad, gsl_vector_int *dlevel, size_t &kc, size_t &kd); + + +#endif + + |