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author | Peter Carbonetto | 2017-06-07 23:23:35 -0500 |
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committer | Peter Carbonetto | 2017-06-07 23:23:35 -0500 |
commit | 93a7a2adb03f61e80badf6a5004fa4850dbb7d48 (patch) | |
tree | 72eb62acf1bc21000cd969e62658261590eab36e /src/mvlmm.h | |
parent | 35e4ee4767c35c2436fea81788742641172ada37 (diff) | |
download | pangemma-93a7a2adb03f61e80badf6a5004fa4850dbb7d48.tar.gz |
Removed FORCE_FLOAT from a few more files.
Diffstat (limited to 'src/mvlmm.h')
-rw-r--r-- | src/mvlmm.h | 81 |
1 files changed, 45 insertions, 36 deletions
diff --git a/src/mvlmm.h b/src/mvlmm.h index 9ff567c..d495c26 100644 --- a/src/mvlmm.h +++ b/src/mvlmm.h @@ -1,6 +1,6 @@ /* Genome-wide Efficient Mixed Model Association (GEMMA) - Copyright (C) 2011 Xiang Zhou + Copyright (C) 2011-2017, Xiang Zhou This program is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License as published by @@ -13,36 +13,25 @@ GNU General Public License for more details. You should have received a copy of the GNU General Public License - along with this program. If not, see <http://www.gnu.org/licenses/>. - */ + along with this program. If not, see <http://www.gnu.org/licenses/>. +*/ #ifndef __MVLMM_H__ #define __MVLMM_H__ #include "gsl/gsl_vector.h" #include "gsl/gsl_matrix.h" - - -#ifdef FORCE_FLOAT -#include "param_float.h" -#include "io_float.h" -#else #include "param.h" #include "io.h" -#endif using namespace std; - - - - class MVLMM { public: - // IO related parameters - int a_mode; //analysis mode, 1/2/3/4 for Frequentist tests - size_t d_pace; //display pace + // IO-related parameters. + int a_mode; // Analysis mode: 1/2/3/4 for Frequentist tests. + size_t d_pace; // Display pace. string file_bfile; string file_geno; @@ -50,48 +39,68 @@ public: string file_out; string path_out; - // MVLMM related parameters + // MVLMM-related parameters. double l_min; double l_max; size_t n_region; double logl_remle_H0, logl_mle_H0; vector<double> Vg_remle_null, Ve_remle_null, Vg_mle_null, Ve_mle_null; - vector<double> VVg_remle_null, VVe_remle_null, VVg_mle_null, VVe_mle_null; - vector<double> beta_remle_null, se_beta_remle_null, beta_mle_null, se_beta_mle_null; + vector<double> VVg_remle_null, VVe_remle_null, VVg_mle_null; + vector<double> VVe_mle_null; + vector<double> beta_remle_null, se_beta_remle_null, beta_mle_null; + vector<double> se_beta_mle_null; double p_nr; size_t em_iter, nr_iter; double em_prec, nr_prec; size_t crt; - // Summary statistics - size_t ni_total, ni_test; //number of individuals - size_t ns_total, ns_test; //number of snps + // Summary statistics. + size_t ni_total, ni_test; // Number of individuals. + size_t ns_total, ns_test; // Number of SNPs. size_t n_cvt; size_t n_ph; - double time_UtX; //time spent on optimization iterations - double time_opt; //time spent on optimization iterations + double time_UtX; // Time spent on optimization iterations. + double time_opt; // Time spent on optimization iterations. + + // Indicator for individuals (phenotypes): 0 missing, 1 + // available for analysis. + vector<int> indicator_idv; - vector<int> indicator_idv; //indicator for individuals (phenotypes), 0 missing, 1 available for analysis - vector<int> indicator_snp; //sequence indicator for SNPs: 0 ignored because of (a) maf, (b) miss, (c) non-poly; 1 available for analysis + // Sequence indicator for SNPs: 0 ignored because of (a) maf, + // (b) miss, (c) non-poly; 1 available for analysis. + vector<int> indicator_snp; - vector<SNPINFO> snpInfo; //record SNP information + vector<SNPINFO> snpInfo; // Record SNP information. - // Not included in PARAM - vector<MPHSUMSTAT> sumStat; //Output SNPSummary Data + // Not included in PARAM. + vector<MPHSUMSTAT> sumStat; // Output SNPSummary Data. // Main functions void CopyFromParam (PARAM &cPar); void CopyToParam (PARAM &cPar); - void AnalyzeBimbam (const gsl_matrix *U, const gsl_vector *eval, const gsl_matrix *UtW, const gsl_matrix *UtY); - void AnalyzePlink (const gsl_matrix *U, const gsl_vector *eval, const gsl_matrix *UtW, const gsl_matrix *UtY); - void Analyzebgen (const gsl_matrix *U, const gsl_vector *eval, const gsl_matrix *UtW, const gsl_matrix *UtY); - void AnalyzeBimbamGXE (const gsl_matrix *U, const gsl_vector *eval, const gsl_matrix *UtW, const gsl_matrix *UtY, const gsl_vector *env); - void AnalyzePlinkGXE (const gsl_matrix *U, const gsl_vector *eval, const gsl_matrix *UtW, const gsl_matrix *UtY, const gsl_vector *env); + void AnalyzeBimbam (const gsl_matrix *U, const gsl_vector *eval, + const gsl_matrix *UtW, const gsl_matrix *UtY); + void AnalyzePlink (const gsl_matrix *U, const gsl_vector *eval, + const gsl_matrix *UtW, const gsl_matrix *UtY); + void Analyzebgen (const gsl_matrix *U, const gsl_vector *eval, + const gsl_matrix *UtW, const gsl_matrix *UtY); + void AnalyzeBimbamGXE (const gsl_matrix *U, const gsl_vector *eval, + const gsl_matrix *UtW, const gsl_matrix *UtY, + const gsl_vector *env); + void AnalyzePlinkGXE (const gsl_matrix *U, const gsl_vector *eval, + const gsl_matrix *UtW, const gsl_matrix *UtY, + const gsl_vector *env); void WriteFiles (); }; -void CalcMvLmmVgVeBeta (const gsl_vector *eval, const gsl_matrix *UtW, const gsl_matrix *UtY, const size_t em_iter, const size_t nr_iter, const double em_prec, const double nr_prec, const double l_min, const double l_max, const size_t n_region, gsl_matrix *V_g, gsl_matrix *V_e, gsl_matrix *B, gsl_matrix *se_B); +void CalcMvLmmVgVeBeta (const gsl_vector *eval, const gsl_matrix *UtW, + const gsl_matrix *UtY, const size_t em_iter, + const size_t nr_iter, const double em_prec, + const double nr_prec, const double l_min, + const double l_max, const size_t n_region, + gsl_matrix *V_g, gsl_matrix *V_e, gsl_matrix *B, + gsl_matrix *se_B); #endif |