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authorPeter Carbonetto2017-06-07 23:23:35 -0500
committerPeter Carbonetto2017-06-07 23:23:35 -0500
commit93a7a2adb03f61e80badf6a5004fa4850dbb7d48 (patch)
tree72eb62acf1bc21000cd969e62658261590eab36e /src/mvlmm.h
parent35e4ee4767c35c2436fea81788742641172ada37 (diff)
downloadpangemma-93a7a2adb03f61e80badf6a5004fa4850dbb7d48.tar.gz
Removed FORCE_FLOAT from a few more files.
Diffstat (limited to 'src/mvlmm.h')
-rw-r--r--src/mvlmm.h81
1 files changed, 45 insertions, 36 deletions
diff --git a/src/mvlmm.h b/src/mvlmm.h
index 9ff567c..d495c26 100644
--- a/src/mvlmm.h
+++ b/src/mvlmm.h
@@ -1,6 +1,6 @@
/*
Genome-wide Efficient Mixed Model Association (GEMMA)
- Copyright (C) 2011 Xiang Zhou
+ Copyright (C) 2011-2017, Xiang Zhou
This program is free software: you can redistribute it and/or modify
it under the terms of the GNU General Public License as published by
@@ -13,36 +13,25 @@
GNU General Public License for more details.
You should have received a copy of the GNU General Public License
- along with this program. If not, see <http://www.gnu.org/licenses/>.
- */
+ along with this program. If not, see <http://www.gnu.org/licenses/>.
+*/
#ifndef __MVLMM_H__
#define __MVLMM_H__
#include "gsl/gsl_vector.h"
#include "gsl/gsl_matrix.h"
-
-
-#ifdef FORCE_FLOAT
-#include "param_float.h"
-#include "io_float.h"
-#else
#include "param.h"
#include "io.h"
-#endif
using namespace std;
-
-
-
-
class MVLMM {
public:
- // IO related parameters
- int a_mode; //analysis mode, 1/2/3/4 for Frequentist tests
- size_t d_pace; //display pace
+ // IO-related parameters.
+ int a_mode; // Analysis mode: 1/2/3/4 for Frequentist tests.
+ size_t d_pace; // Display pace.
string file_bfile;
string file_geno;
@@ -50,48 +39,68 @@ public:
string file_out;
string path_out;
- // MVLMM related parameters
+ // MVLMM-related parameters.
double l_min;
double l_max;
size_t n_region;
double logl_remle_H0, logl_mle_H0;
vector<double> Vg_remle_null, Ve_remle_null, Vg_mle_null, Ve_mle_null;
- vector<double> VVg_remle_null, VVe_remle_null, VVg_mle_null, VVe_mle_null;
- vector<double> beta_remle_null, se_beta_remle_null, beta_mle_null, se_beta_mle_null;
+ vector<double> VVg_remle_null, VVe_remle_null, VVg_mle_null;
+ vector<double> VVe_mle_null;
+ vector<double> beta_remle_null, se_beta_remle_null, beta_mle_null;
+ vector<double> se_beta_mle_null;
double p_nr;
size_t em_iter, nr_iter;
double em_prec, nr_prec;
size_t crt;
- // Summary statistics
- size_t ni_total, ni_test; //number of individuals
- size_t ns_total, ns_test; //number of snps
+ // Summary statistics.
+ size_t ni_total, ni_test; // Number of individuals.
+ size_t ns_total, ns_test; // Number of SNPs.
size_t n_cvt;
size_t n_ph;
- double time_UtX; //time spent on optimization iterations
- double time_opt; //time spent on optimization iterations
+ double time_UtX; // Time spent on optimization iterations.
+ double time_opt; // Time spent on optimization iterations.
+
+ // Indicator for individuals (phenotypes): 0 missing, 1
+ // available for analysis.
+ vector<int> indicator_idv;
- vector<int> indicator_idv; //indicator for individuals (phenotypes), 0 missing, 1 available for analysis
- vector<int> indicator_snp; //sequence indicator for SNPs: 0 ignored because of (a) maf, (b) miss, (c) non-poly; 1 available for analysis
+ // Sequence indicator for SNPs: 0 ignored because of (a) maf,
+ // (b) miss, (c) non-poly; 1 available for analysis.
+ vector<int> indicator_snp;
- vector<SNPINFO> snpInfo; //record SNP information
+ vector<SNPINFO> snpInfo; // Record SNP information.
- // Not included in PARAM
- vector<MPHSUMSTAT> sumStat; //Output SNPSummary Data
+ // Not included in PARAM.
+ vector<MPHSUMSTAT> sumStat; // Output SNPSummary Data.
// Main functions
void CopyFromParam (PARAM &cPar);
void CopyToParam (PARAM &cPar);
- void AnalyzeBimbam (const gsl_matrix *U, const gsl_vector *eval, const gsl_matrix *UtW, const gsl_matrix *UtY);
- void AnalyzePlink (const gsl_matrix *U, const gsl_vector *eval, const gsl_matrix *UtW, const gsl_matrix *UtY);
- void Analyzebgen (const gsl_matrix *U, const gsl_vector *eval, const gsl_matrix *UtW, const gsl_matrix *UtY);
- void AnalyzeBimbamGXE (const gsl_matrix *U, const gsl_vector *eval, const gsl_matrix *UtW, const gsl_matrix *UtY, const gsl_vector *env);
- void AnalyzePlinkGXE (const gsl_matrix *U, const gsl_vector *eval, const gsl_matrix *UtW, const gsl_matrix *UtY, const gsl_vector *env);
+ void AnalyzeBimbam (const gsl_matrix *U, const gsl_vector *eval,
+ const gsl_matrix *UtW, const gsl_matrix *UtY);
+ void AnalyzePlink (const gsl_matrix *U, const gsl_vector *eval,
+ const gsl_matrix *UtW, const gsl_matrix *UtY);
+ void Analyzebgen (const gsl_matrix *U, const gsl_vector *eval,
+ const gsl_matrix *UtW, const gsl_matrix *UtY);
+ void AnalyzeBimbamGXE (const gsl_matrix *U, const gsl_vector *eval,
+ const gsl_matrix *UtW, const gsl_matrix *UtY,
+ const gsl_vector *env);
+ void AnalyzePlinkGXE (const gsl_matrix *U, const gsl_vector *eval,
+ const gsl_matrix *UtW, const gsl_matrix *UtY,
+ const gsl_vector *env);
void WriteFiles ();
};
-void CalcMvLmmVgVeBeta (const gsl_vector *eval, const gsl_matrix *UtW, const gsl_matrix *UtY, const size_t em_iter, const size_t nr_iter, const double em_prec, const double nr_prec, const double l_min, const double l_max, const size_t n_region, gsl_matrix *V_g, gsl_matrix *V_e, gsl_matrix *B, gsl_matrix *se_B);
+void CalcMvLmmVgVeBeta (const gsl_vector *eval, const gsl_matrix *UtW,
+ const gsl_matrix *UtY, const size_t em_iter,
+ const size_t nr_iter, const double em_prec,
+ const double nr_prec, const double l_min,
+ const double l_max, const size_t n_region,
+ gsl_matrix *V_g, gsl_matrix *V_e, gsl_matrix *B,
+ gsl_matrix *se_B);
#endif