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| author | root | 2012-05-08 18:39:56 -0500 |
|---|---|---|
| committer | root | 2012-05-08 18:39:56 -0500 |
| commit | ea46f42ee640928b92947bfb204c41a482d80937 (patch) | |
| tree | 9b27a4eb852d12539b543c3efee9d2a47ef470f3 /web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0059.htm | |
| parent | 056b5253fc3857b0444382aa39944f6344dc1ceb (diff) | |
| download | genenetwork2-ea46f42ee640928b92947bfb204c41a482d80937.tar.gz | |
Add all the source codes into the github.
Diffstat (limited to 'web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0059.htm')
| -rwxr-xr-x | web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0059.htm | 104 |
1 files changed, 104 insertions, 0 deletions
diff --git a/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0059.htm b/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0059.htm new file mode 100755 index 00000000..5ba9ff5c --- /dev/null +++ b/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0059.htm @@ -0,0 +1,104 @@ +<html>
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<title>PowerPoint Presentation - Complex trait analysis, develop-ment, and
genomics</title>
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mso-text-indent-alt:0;mso-line-spacing:"-358 0 -1";mso-margin-left-alt:233;
mso-text-indent-alt:0'><span style='font-family:Verdana;font-size:64%'>Evaluating
</span><span style='font-family:Verdana;font-size:64%'><i>Ctbp2</i></span><span
style='font-family:Verdana;font-size:64%'> using other resources</span><span
style='font-family:Verdana;font-size:73%;mso-special-format:lastCR;display:
none'><i><br>
</i></span></div>
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<div id=NotesObj style='display:none'>
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<td width=5 nowrap></td>
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<td align=left colspan=1><font face=Verdana size=3>Ctbp2 should also be
considered a high priority biological candidate gene responsible for
modulating App expression levels. The<span style="mso-spacerun: yes">
</span>C-terminal binding protein 2 is a transcriptional co-repressor also
known as Ribeye.</font><font face=Times-Roman size=3> The gene produces two
transcripts encoding distinct proteins. The short form is a transcriptional
repressor that binds a Pro-X-Asp-Leu-Ser peptide motif common to adenoviral
oncoprotein E1a and a related motif in BKLF. This short form also interacts<span
style="mso-spacerun: yes"> </span>with several transcription factors
including EVI1, ZFPM1, and<span style="mso-spacerun: yes">
</span>ZFHX1A (aka TCF8, deltaEF1). The longer isoform is a major component
of specialized synapses in photoreceptors. Both proteins contain a NAD+
binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases.</font><br>
</td>
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<td align=left colspan=1><font face=Verdana size=3>Notes:</font><br>
</td>
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<td align=left colspan=1><font face=Verdana size=3>1. To find out more about
CTBP2 protein and the Ctbp2 gene, link to iHOP at
http://www.pdg.cnb.uam.es/UniPub/iHOP/ and type in CTBP2</font><br>
</td>
</tr>
<tr>
<td colspan=1></td>
<td align=left colspan=1><font face=Verdana size=3>Try Arrowsmith at
http://arrowsmith.psych.uic.edu/cgi-test/arrowsmith_uic/pubsmith.cgi</font><br>
</td>
</tr>
<tr>
<td colspan=1></td>
<td align=left colspan=1><font face=Verdana size=3>2. Both APP and CTBP2 are
involved in oxidoreducatase activity or Notch signalling. To estabilish this
common gene ontology visit NCBI<span style="mso-spacerun: yes">
</span>http://www.ncbi.nih.gov/entrez/query.fcgi?db=gene<span
style="mso-spacerun: yes"> </span>and enter each gene symbol.</font><br>
</td>
</tr>
<tr>
<td colspan=1></td>
<td align=left colspan=1><font face=Verdana size=3>3. You can get intersting
hints regarding Ctbp2 expression partners by examining the genetic
correlations between Ctbp2 probe set 1422887_a_at and all other transcripts
on the M430 Affymetrix array. Use the Striatum data set because we already
know from previous work (the previous slide) that this gene is a cis
QTL.<span style="mso-spacerun: yes"> </span>You should be able to show
that Ctbp2 and Notch3 have antagonistic expression patterns in striatum. The
negative genetic correlation with E2f4 is even stronger. The transcript also
has a high positive genetic correlation with Rdh14. Of particualr interest
with respect to APP protein processing, Ctbp2 covaries positiviely with
Bace2 (the transcript of the beta site APP-cleaving enzyme 2).</font><br>
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</td>
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