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authorroot2012-05-08 18:39:56 -0500
committerroot2012-05-08 18:39:56 -0500
commitea46f42ee640928b92947bfb204c41a482d80937 (patch)
tree9b27a4eb852d12539b543c3efee9d2a47ef470f3 /web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0054.htm
parent056b5253fc3857b0444382aa39944f6344dc1ceb (diff)
downloadgenenetwork2-ea46f42ee640928b92947bfb204c41a482d80937.tar.gz
Add all the source codes into the github.
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<head>
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<title>PowerPoint Presentation  -  Complex trait analysis, develop-ment, and
genomics</title>
<link title="Presentation File" type="application/powerpoint" rel=alternate
href="webqtl_demo2.ppt.ppt">
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<meta name=Description
content="Jul-18-05: Genetic versus Physical maps for App expression">
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mso-text-indent-alt:0;mso-line-spacing:"-358 0 -1";mso-margin-left-alt:233;
mso-text-indent-alt:0'><span style='font-family:Verdana;font-size:64%'><i>Genetic
versus Physical maps for App expression</i></span><span style='font-family:
Verdana;font-size:73%;mso-special-format:lastCR;display:none'><i><br>
</i></span></div>

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<div style='text-align:left;font-family:Verdana;font-weight:normal;font-style:
normal;text-decoration:none;text-shadow:none;text-effect:none;mso-fareast-hint:
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+</script><span
style='text-align:left'><span style='font-size:117%;color:#E9EB5D'><i>The
difference between genetic and physical scale is analogous to measuring the </i></span></span></layer><script>
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style='text-align:left'><span style='font-size:117%;color:#E9EB5D'><i>separation
between New York and Boston in either travel hours or kilometers</i></span><span
style='font-size:150%;color:#E9EB5D'><i>.</i></span><span style='font-size:
167%;color:#E9EB5D;mso-special-format:lastCR;display:none'><i><br>
</i></span></span></layer></div>

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+

<layer>
 <div id=NotesObj style='display:none'>
 <table style='color:white' border=0 width="100%">
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   <td align=left colspan=1><font face=Verdana size=3>The map on the top has an
   X-axis scale based on frequency of recombinations events between markers (B
   to D transitions, see slide 19 for a color-coded example). These so-called
   genetic maps are scaled in centimorgan (recombinations per 100 gametes). In
   contrast, the physical map shown below the genetic map has an X-axis scale
   based on DNA length measured in nucleotides or base-pairs. Notice the large
   difference between the two maps in the size of Chr 19 (large on the genetic
   scale but small on the physical scale).</font><br>
   </td>
  </tr>
  <tr>
   <td colspan=1></td>
   <td align=left colspan=1><font face=Verdana size=3>Also notice the large
   difference in the width of the chromosome 7 QTL peak. In mice,
   recombinations occur with higher frequency toward the telomeric side (righ
   sidet) of each chromosome. As a result, genetic maps are stretched out more
   toward the telomere relative to a physical map. The QTL on distal Chr 7 is
   therefore actually more precisely mapped than might appear looking at the
   genetic map.</font><br>
   </td>
  </tr>
  <tr>
   <td colspan=1></td>
   <td align=left colspan=1><font face=Verdana size=3>The physical scale is
   becoming more useful than the genetic scale primarily because many other
   data types can be easily superimposed on a physical map. You will see more
   examples in the next several slides.</font><br>
   </td>
  </tr>
 </table>
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