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{% extends "layout.html" %}
{% block content %}
{{ message | safe }}
<h3> <u>R</u>elationship with <u>A</u>ddiction <u>T</u>hrough <u>S</u>earches of <u>Pub</u>Med </span></a>
</h3>
<table>
<tr><td >
<p>
RatsPub searches PubMed to find <i>sentences</i> that contain the query terms (i.e., gene symbols) and <a href="https://github.com/chen42/RatsPub/blob/master/ratspub_keywords.py">drug addiction-related keywords</a>. These gene-keyword relationships are presented as an interactive graph that can efficiently answer the question <b>"What do we know about these genes and addiction?". </b> To better answer this question, data from <a href="https://www.ebi.ac.uk/gwas/">EBI GWAS catalog </a>are also included in the search.
<p> The graph has many interactive elements. For example, clicking gene names will launch a new search for sentences containing the target gene and 200 addiction-related genes. These results help to answer the question <b>"Are there genes that can link my gene of interest to addiction?" </b>
</td>
<td >
<div class='img'><img src="/static/ratspub.png" class="img-fluid">
</td></tr>
<tr><td colspan=2>
Up to 100 gene symbols can be searched at a time. Gene symbols can be separated by either a space or a semicolon. Gene alias will <i>not</i> be automatically included because the large number of false matches associated with gene synonyms retrieved from databases.
</td></tr></table>
<p>
<b>Example</b>: Rgma Nrxn3; Chrna3
<br>
<form action="/progress">
<textarea name="query" class="form-control form-control-lg" type="search" row="3" id="searchform">
</textarea>
<div class="form-group row">
<div class="col-sm-10">
<button type="submit" class="btn btn-primary">Submit</button>
</div>
</div>
</form>
{% endblock %}
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