1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
|
addiction_d = {"reward":"reward|hedonic|incentive|intracranial self stimulation|ICSS|reinforcement|reinforcing|conditioned place preference|CPP|self administration|self administered|drug reinforced|operant|instrumental response",
"aversion":"aversion|aversive|CTA|conditioned taste aversion",
"withdrawal":"withdrawal",
"relapse":"relapse|reinstatement|craving|drug seeking|seeking",
"sensitization":"sensitization",
"addiction":"addiction|addictive|drug abuse|punishment|compulsive|escalation",
"dependence":"dependence",
"intoxication":"intoxication|binge"
}
drug_d = {"alcohol":"alcohol|alcoholism|alcoholic|alcoholics",
"nicotine":"smoking|nicotine|tobacco|smoker|smokers",
"cocaine":"cocaine",
"opioid":"opioid|opioids|fentanyl|oxycodone|oxycontin|heroin|morphine|methadone|buprenorphine|vicodin|hydrocodone|hycodan|kadian|percoset|hydromorphone|naloxone|codeine|suboxone|tramadol|kratom|ultram",
"amphetamine":"methamphetamine|amphetamine|METH|AMPH",
"cannabinoid":"endocannabinoid|cannabinoids|cannabis|endocannabinoids|marijuana|cannabidiol|cannabinoid|tetrahydrocannabinol|thc|thc 9|Oleoylethanolamide|palmitoylethanolamide|acylethanolamides"
}
brain_d ={"cortex":"cortex|prefrontal|pfc|mPFC|vmpfc|corticostriatal|cortico limbic|corticolimbic|prl|prelimbic|infralimbic|orbitofrontal|cingulate|cerebral|insular|insula",
"striatum":"striatum|STR|striatal|caudate|putamen|basal ganglia|globus pallidus|GPI",
"accumbens":"accumbens|accumbal|shell|core|Nacc|NacSh|acbs|acbc",
"hippocampus":"hippocampus|hippocampal|hipp|hip|ca1|ca3|dentate gyrus|subiculum|vhipp|dhpc|vhpc",
"amygdala":"amygdala|cea|bla|amy|cna",
"VTA":"ventral tegmental|vta|pvta|mesolimbic|limbic|midbrain|mesoaccumbens|mesoaccumbal",
"habenula":"habenula|lhb|mhb",
"hypothalamus":"hypothalamus|hypothalamic|PVN|paraventricular nucleus|LHA"
}
# brain region has too many short acronyms to just use the undic function, so search PubMed using the following
brain_query_term="cortex|accumbens|striatum|amygadala|hippocampus|tegmental|mesolimbic|infralimbic|prelimbic|habenula"
function_d={"signalling":"signalling|signaling|phosphorylation|glycosylation",
"transcription":"transcription|methylation|hypomethylation|hypermethylation|histone|ribosome",
"neuroplasticity":"neuroplasticity|plasticity|long term potentiation|LTP|long term depression|LTD|synaptic|epsp|epsc|neurite|neurogenesis|boutons|mIPSC|IPSC|IPSP",
"neurotransmission": "neurotransmission|neuropeptides|neuropeptide|glutamate|glutamatergic|GABA|GABAergic|dopamine|dopaminergic|DAergic|cholinergic|nicotinic|muscarinic|serotonergic|serotonin|5 ht|acetylcholine",
}
#"regulation":"increased|decreased|regulated|inhibited|stimulated",
|
