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/*
Genome-wide Efficient Mixed Model Association (GEMMA)
Copyright (C) 2011-2017, Xiang Zhou
This program is free software: you can redistribute it and/or modify
it under the terms of the GNU General Public License as published by
the Free Software Foundation, either version 3 of the License, or
(at your option) any later version.
This program is distributed in the hope that it will be useful,
but WITHOUT ANY WARRANTY; without even the implied warranty of
MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
GNU General Public License for more details.
You should have received a copy of the GNU General Public License
along with this program. If not, see <http://www.gnu.org/licenses/>.
*/
#ifndef __MVLMM_H__
#define __MVLMM_H__
#include "gsl/gsl_matrix.h"
#include "gsl/gsl_vector.h"
#include "io.h"
#include "param.h"
using namespace std;
class MVLMM {
public:
// IO-related parameters.
int a_mode; // Analysis mode: 1/2/3/4 for Frequentist tests.
size_t d_pace; // Display pace.
string file_bfile;
string file_geno;
string file_oxford;
string file_out;
string path_out;
// MVLMM-related parameters.
double l_min;
double l_max;
size_t n_region;
double logl_remle_H0, logl_mle_H0;
vector<double> Vg_remle_null, Ve_remle_null, Vg_mle_null, Ve_mle_null;
vector<double> VVg_remle_null, VVe_remle_null, VVg_mle_null;
vector<double> VVe_mle_null;
vector<double> beta_remle_null, se_beta_remle_null, beta_mle_null;
vector<double> se_beta_mle_null;
double p_nr;
size_t em_iter, nr_iter;
double em_prec, nr_prec;
size_t crt;
// Summary statistics.
size_t ni_total, ni_test; // Number of individuals.
size_t ns_total, ns_test; // Number of SNPs.
size_t n_cvt;
size_t n_ph;
double time_UtX; // Time spent on optimization iterations.
double time_opt; // Time spent on optimization iterations.
// Indicator for individuals (phenotypes): 0 missing, 1
// available for analysis.
vector<int> indicator_idv;
// Sequence indicator for SNPs: 0 ignored because of (a) maf,
// (b) miss, (c) non-poly; 1 available for analysis.
vector<int> indicator_snp;
vector<SNPINFO> snpInfo; // Record SNP information.
// Not included in PARAM.
vector<MPHSUMSTAT> sumStat; // Output SNPSummary Data.
// Main functions
void CopyFromParam(PARAM &cPar);
void CopyToParam(PARAM &cPar);
void AnalyzeBimbam(const gsl_matrix *U, const gsl_vector *eval,
const gsl_matrix *UtW, const gsl_matrix *UtY);
void AnalyzePlink(const gsl_matrix *U, const gsl_vector *eval,
const gsl_matrix *UtW, const gsl_matrix *UtY);
void Analyzebgen(const gsl_matrix *U, const gsl_vector *eval,
const gsl_matrix *UtW, const gsl_matrix *UtY);
void AnalyzeBimbamGXE(const gsl_matrix *U, const gsl_vector *eval,
const gsl_matrix *UtW, const gsl_matrix *UtY,
const gsl_vector *env);
void AnalyzePlinkGXE(const gsl_matrix *U, const gsl_vector *eval,
const gsl_matrix *UtW, const gsl_matrix *UtY,
const gsl_vector *env);
void WriteFiles();
};
void CalcMvLmmVgVeBeta(const gsl_vector *eval, const gsl_matrix *UtW,
const gsl_matrix *UtY, const size_t em_iter,
const size_t nr_iter, const double em_prec,
const double nr_prec, const double l_min,
const double l_max, const size_t n_region,
gsl_matrix *V_g, gsl_matrix *V_e, gsl_matrix *B,
gsl_matrix *se_B);
#endif
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