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authorPjotr Prins2017-08-02 08:46:58 +0000
committerPjotr Prins2017-08-02 08:46:58 +0000
commit3935ba39d30666dd7d4a831155631847c77b70c4 (patch)
treec45fc682b473618a219e324d5c85b5e1f9361d0c /src/lmm.h
parent84360c191f418bf8682b35e0c8235fcc3bd19a06 (diff)
downloadpangemma-3935ba39d30666dd7d4a831155631847c77b70c4.tar.gz
Massive patch using LLVM coding style. It was generated with:
clang-format -style=LLVM -i *.cpp *.h Please set your editor to replace tabs with spaces and use indentation of 2 spaces.
Diffstat (limited to 'src/lmm.h')
-rw-r--r--src/lmm.h197
1 files changed, 97 insertions, 100 deletions
diff --git a/src/lmm.h b/src/lmm.h
index 9c3de9d..c393daf 100644
--- a/src/lmm.h
+++ b/src/lmm.h
@@ -19,120 +19,117 @@
#ifndef __LMM_H__
#define __LMM_H__
-#include "gsl/gsl_vector.h"
#include "gsl/gsl_matrix.h"
-#include "param.h"
+#include "gsl/gsl_vector.h"
#include "io.h"
+#include "param.h"
using namespace std;
class FUNC_PARAM {
public:
- bool calc_null;
- size_t ni_test;
- size_t n_cvt;
- const gsl_vector *eval;
- const gsl_matrix *Uab;
- const gsl_vector *ab;
- size_t e_mode;
+ bool calc_null;
+ size_t ni_test;
+ size_t n_cvt;
+ const gsl_vector *eval;
+ const gsl_matrix *Uab;
+ const gsl_vector *ab;
+ size_t e_mode;
};
class LMM {
public:
- // IO-related parameters
- int a_mode; // Analysis mode: 1/2/3/4 for Frequentist tests.
- size_t d_pace; // Display pace.
-
- string file_bfile;
- string file_geno;
- string file_out;
- string path_out;
-
- string file_gene;
- // WJA added
- string file_oxford;
-
- // LMM related parameters
- double l_min;
- double l_max;
- size_t n_region;
- double l_mle_null;
- double logl_mle_H0;
-
- // Summary statistics
- size_t ni_total, ni_test; // Number of individuals.
- size_t ns_total, ns_test; // Number of SNPs.
- size_t ng_total, ng_test; // Number of genes.
- size_t n_cvt;
- double time_UtX; // Time spent on optimization iterations.
- double time_opt; // Time spent on optimization iterations.
-
- // Indicator for individuals (phenotypes): 0 missing, 1
- // available for analysis.
- vector<int> indicator_idv;
-
- // Sequence indicator for SNPs: 0 ignored because of (a) maf,
- // (b) miss, (c) non-poly; 1 available for analysis.
- vector<int> indicator_snp;
-
- vector<SNPINFO> snpInfo; // Record SNP information.
-
- // Not included in PARAM.
- vector<SUMSTAT> sumStat; // Output SNPSummary Data.
-
- // Main functions.
- void CopyFromParam (PARAM &cPar);
- void CopyToParam (PARAM &cPar);
- void AnalyzeGene (const gsl_matrix *U, const gsl_vector *eval,
- const gsl_matrix *UtW, const gsl_vector *Utx,
- const gsl_matrix *W, const gsl_vector *x);
- void AnalyzePlink (const gsl_matrix *U, const gsl_vector *eval,
- const gsl_matrix *UtW, const gsl_vector *Uty,
- const gsl_matrix *W, const gsl_vector *y);
- // WJA added.
- void Analyzebgen (const gsl_matrix *U, const gsl_vector *eval,
- const gsl_matrix *UtW, const gsl_vector *Uty,
- const gsl_matrix *W, const gsl_vector *y);
- void AnalyzeBimbam (const gsl_matrix *U, const gsl_vector *eval,
- const gsl_matrix *UtW, const gsl_vector *Uty,
- const gsl_matrix *W, const gsl_vector *y);
- void AnalyzePlinkGXE (const gsl_matrix *U, const gsl_vector *eval,
- const gsl_matrix *UtW, const gsl_vector *Uty,
- const gsl_matrix *W, const gsl_vector *y,
- const gsl_vector *env);
- void AnalyzeBimbamGXE (const gsl_matrix *U, const gsl_vector *eval,
- const gsl_matrix *UtW, const gsl_vector *Uty,
- const gsl_matrix *W, const gsl_vector *y,
- const gsl_vector *env);
- void WriteFiles ();
-
- void CalcRLWald (const double &lambda, const FUNC_PARAM &params,
- double &beta, double &se, double &p_wald);
- void CalcRLScore (const double &l, const FUNC_PARAM &params,
- double &beta, double &se, double &p_score);
+ // IO-related parameters
+ int a_mode; // Analysis mode: 1/2/3/4 for Frequentist tests.
+ size_t d_pace; // Display pace.
+
+ string file_bfile;
+ string file_geno;
+ string file_out;
+ string path_out;
+
+ string file_gene;
+ // WJA added
+ string file_oxford;
+
+ // LMM related parameters
+ double l_min;
+ double l_max;
+ size_t n_region;
+ double l_mle_null;
+ double logl_mle_H0;
+
+ // Summary statistics
+ size_t ni_total, ni_test; // Number of individuals.
+ size_t ns_total, ns_test; // Number of SNPs.
+ size_t ng_total, ng_test; // Number of genes.
+ size_t n_cvt;
+ double time_UtX; // Time spent on optimization iterations.
+ double time_opt; // Time spent on optimization iterations.
+
+ // Indicator for individuals (phenotypes): 0 missing, 1
+ // available for analysis.
+ vector<int> indicator_idv;
+
+ // Sequence indicator for SNPs: 0 ignored because of (a) maf,
+ // (b) miss, (c) non-poly; 1 available for analysis.
+ vector<int> indicator_snp;
+
+ vector<SNPINFO> snpInfo; // Record SNP information.
+
+ // Not included in PARAM.
+ vector<SUMSTAT> sumStat; // Output SNPSummary Data.
+
+ // Main functions.
+ void CopyFromParam(PARAM &cPar);
+ void CopyToParam(PARAM &cPar);
+ void AnalyzeGene(const gsl_matrix *U, const gsl_vector *eval,
+ const gsl_matrix *UtW, const gsl_vector *Utx,
+ const gsl_matrix *W, const gsl_vector *x);
+ void AnalyzePlink(const gsl_matrix *U, const gsl_vector *eval,
+ const gsl_matrix *UtW, const gsl_vector *Uty,
+ const gsl_matrix *W, const gsl_vector *y);
+ // WJA added.
+ void Analyzebgen(const gsl_matrix *U, const gsl_vector *eval,
+ const gsl_matrix *UtW, const gsl_vector *Uty,
+ const gsl_matrix *W, const gsl_vector *y);
+ void AnalyzeBimbam(const gsl_matrix *U, const gsl_vector *eval,
+ const gsl_matrix *UtW, const gsl_vector *Uty,
+ const gsl_matrix *W, const gsl_vector *y);
+ void AnalyzePlinkGXE(const gsl_matrix *U, const gsl_vector *eval,
+ const gsl_matrix *UtW, const gsl_vector *Uty,
+ const gsl_matrix *W, const gsl_vector *y,
+ const gsl_vector *env);
+ void AnalyzeBimbamGXE(const gsl_matrix *U, const gsl_vector *eval,
+ const gsl_matrix *UtW, const gsl_vector *Uty,
+ const gsl_matrix *W, const gsl_vector *y,
+ const gsl_vector *env);
+ void WriteFiles();
+
+ void CalcRLWald(const double &lambda, const FUNC_PARAM &params, double &beta,
+ double &se, double &p_wald);
+ void CalcRLScore(const double &l, const FUNC_PARAM &params, double &beta,
+ double &se, double &p_score);
};
-void MatrixCalcLR (const gsl_matrix *U, const gsl_matrix *UtX,
- const gsl_vector *Uty, const gsl_vector *K_eval,
- const double l_min, const double l_max,
- const size_t n_region,
- vector<pair<size_t, double> > &pos_loglr);
-void CalcLambda (const char func_name, FUNC_PARAM &params,
- const double l_min, const double l_max,
- const size_t n_region, double &lambda, double &logf);
-void CalcLambda (const char func_name, const gsl_vector *eval,
- const gsl_matrix *UtW, const gsl_vector *Uty,
- const double l_min, const double l_max,
- const size_t n_region, double &lambda, double &logl_H0);
-void CalcPve (const gsl_vector *eval, const gsl_matrix *UtW,
- const gsl_vector *Uty, const double lambda,
- const double trace_G, double &pve, double &pve_se);
-void CalcLmmVgVeBeta (const gsl_vector *eval, const gsl_matrix *UtW,
- const gsl_vector *Uty, const double lambda, double &vg,
- double &ve, gsl_vector *beta, gsl_vector *se_beta);
+void MatrixCalcLR(const gsl_matrix *U, const gsl_matrix *UtX,
+ const gsl_vector *Uty, const gsl_vector *K_eval,
+ const double l_min, const double l_max, const size_t n_region,
+ vector<pair<size_t, double>> &pos_loglr);
+void CalcLambda(const char func_name, FUNC_PARAM &params, const double l_min,
+ const double l_max, const size_t n_region, double &lambda,
+ double &logf);
+void CalcLambda(const char func_name, const gsl_vector *eval,
+ const gsl_matrix *UtW, const gsl_vector *Uty,
+ const double l_min, const double l_max, const size_t n_region,
+ double &lambda, double &logl_H0);
+void CalcPve(const gsl_vector *eval, const gsl_matrix *UtW,
+ const gsl_vector *Uty, const double lambda, const double trace_G,
+ double &pve, double &pve_se);
+void CalcLmmVgVeBeta(const gsl_vector *eval, const gsl_matrix *UtW,
+ const gsl_vector *Uty, const double lambda, double &vg,
+ double &ve, gsl_vector *beta, gsl_vector *se_beta);
#endif
-
-