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authorPeter Carbonetto2017-05-04 14:43:12 -0500
committerPeter Carbonetto2017-05-04 14:43:12 -0500
commit0dd4e05fc8babc1517de1d7981a99ad0a5241a5e (patch)
tree759b47320ed404951ecb745e228c1fcc0a2200d5 /src/ldr.h
parentc18588b6d00650b9ce742229fdf1eca7133f58fc (diff)
downloadpangemma-0dd4e05fc8babc1517de1d7981a99ad0a5241a5e.tar.gz
Added new files shared by Xiang via email on May 4, 2017.
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+/*
+ Genome-wide Efficient Mixed Model Association (GEMMA)
+ Copyright (C) 2011 Xiang Zhou
+
+ This program is free software: you can redistribute it and/or modify
+ it under the terms of the GNU General Public License as published by
+ the Free Software Foundation, either version 3 of the License, or
+ (at your option) any later version.
+
+ This program is distributed in the hope that it will be useful,
+ but WITHOUT ANY WARRANTY; without even the implied warranty of
+ MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
+ GNU General Public License for more details.
+
+ You should have received a copy of the GNU General Public License
+ along with this program. If not, see <http://www.gnu.org/licenses/>.
+ */
+
+
+#ifndef __LDR_H__
+#define __LDR_H__
+
+#include <vector>
+#include <map>
+#include <gsl/gsl_rng.h>
+#include <gsl/gsl_randist.h>
+
+#ifdef FORCE_FLOAT
+#include "param_float.h"
+#else
+#include "param.h"
+#endif
+
+
+using namespace std;
+
+
+
+
+
+
+class LDR {
+
+public:
+ // IO related parameters
+ int a_mode;
+ size_t d_pace;
+
+ string file_bfile;
+ string file_geno;
+ string file_out;
+ string path_out;
+
+ // Summary statistics
+ size_t ni_total, ns_total; //number of total individuals and snps
+ size_t ni_test, ns_test; //number of individuals and snps used for analysis
+ size_t n_cvt; //number of covariates
+ vector<int> indicator_idv; //indicator for individuals (phenotypes), 0 missing, 1 available for analysis
+ vector<int> indicator_snp; //sequence indicator for SNPs: 0 ignored because of (a) maf, (b) miss, (c) non-poly; 1 available for analysis
+
+ vector<SNPINFO> snpInfo; //record SNP information
+
+ // Not included in PARAM
+ gsl_rng *gsl_r;
+
+ // Main Functions
+ void CopyFromParam (PARAM &cPar);
+ void CopyToParam (PARAM &cPar);
+
+ void VB(const vector<vector<unsigned char> > &Xt, const gsl_matrix *W_gsl, const gsl_vector *y_gsl);
+};
+
+
+
+#endif
+
+