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#! Run from base dir with
. .guix-shell -- guile -L . -s ./scripts/precompute/precompute-hits.scm
and with some extra paths
. .guix-shell ruby --expose=/home/wrk/iwrk/opensource/code/genetics/gemma-wrapper/=/gemma-wrapper --expose=/home/wrk/iwrk/opensource/code/genetics/gemma/=/gemma -- env TMPDIR=tmp guile -L . -s ./scripts/precompute/precompute-hits.scm
You may want to forward a mysql port if there is no DB locally
ssh -L 3306:127.0.0.1:3306 -f -N tux02.genenetwork.org
!#
(use-modules (dbi dbi)
(gn db mysql)
(gn data dataset)
(gn data hits)
(gn data strains)
(gn util convert)
(gn runner gemma)
; (rnrs base)
(ice-9 match)
(srfi srfi-1)
)
;; potentially you want to test connection with mysql client:
;;
;; mysql -uwebqtlout -pwebqtlout -A -h 127.0.0.1 -P 3306 db_webqtl -e "show tables;"
;;
;; for now update Locus_old with
;;
;; update ProbeSetXRef set Locus_old=NULL;
(call-with-db
(lambda (db)
(begin
;(newline)
; (dbi-query db "SELECT StrainId,Strain.Name FROM Strain, StrainXRef WHERE StrainXRef.StrainId = Strain.Id AND StrainXRef.InbredSetId = 1 AND Used_for_mapping='Y' ORDER BY StrainId;")
; (let [(row (get-row db))]
; (display row)
; )
;(let [(result (get-rows-apply db (lambda (r) `(,(assoc-ref r "StrainId") . ,(assoc-ref r "Name"))) '()))]
; (display (car result)))
;; ---- fetch all known BXD sample/individual/strain names
(define bxd-strains (bxd-strain-id-names #:map? #t))
;(display (assoc 64728 bxd-strains))
;(newline)
;(newline)
;(dbi-query db "SELECT * FROM ProbeSetXRef LIMIT 3")
;(let [(row (get-row db))]
; (display row)
; )
;(db-check2 db)
;(newline)
;; ---- get first available dataset for precompute:
;; @@ order by dataid - recurse
(define (get-trait db probeset-id)
(dbi-query db (string-append "select Id,Chr,Mb,Name,Symbol,description from ProbeSet where Id=" (int-to-string probeset-id) " limit 1"))
(get-row db)
)
(define (run-precompute db prev-id)
(let [(hit (get-precompute-hit db prev-id))]
(if hit
(let* [(data-id (assoc-ref hit "DataId"))
(data-id-str (int-to-string data-id))
(probesetfreeze-id (assoc-ref hit "ProbeSetFreezeId"))
(probeset-id (assoc-ref hit "ProbeSetId"))
(trait (get-trait db probeset-id))
(trait-name (assoc-ref trait "Name"))
(name (dataset-name db probesetfreeze-id))
]
(display hit)
(display data-id)
(newline)
;; ---- Get strains and phenotypes for this dataset
(dbi-query db (string-append "SELECT StrainId,value from ProbeSetData WHERE Id=" data-id-str))
(define id_traits (get-rows-apply db
(lambda (r) `(,(assoc-ref r "StrainId") . ,(assoc-ref r "value")))
'()))
;; ---- Now we need to make sure that all strains belong to BXD
(define non-bxd (fold
(lambda (strain lst)
(let* [(id (car strain))
(name (assoc id bxd-strains))]
(if name
lst
(append lst `(,name)))))
'()
id_traits))
(define traits (map
(lambda (t)
(match t
((id . value) (cons (assoc-ref bxd-strains id) value)
)))
id_traits))
;; (display traits)
;; (if (= 0 (length non-bxd))
(if (eq? non-bxd '())
(begin
(set-precompute-hit-status! db data-id-str "GEMMA-START")
(run-gemma "BXD" data-id probeset-id probesetfreeze-id name trait-name traits)
(set-precompute-hit-status! db data-id-str "GEMMA-DONE"))
;; disable precompute if non-bxd, for now, so it won't try again
(set-precompute-hit-status! db data-id-str "NON-BXD"))
(run-precompute db data-id) ;; next round
))))
(run-precompute db 0) ;; start precompute
)))
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