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<ol>
	<li><a href="http://nar.oxfordjournals.org/search?author1=Michele+Pinelli&amp;sortspec=date&amp;submit=Submit">Michele Pinelli</a><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-1" id="xref-aff-1-1"><sup>1</sup></a>,<a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#corresp-3" id="xref-corresp-3-1"><sup>&dagger;</sup></a>,&nbsp;</li>
	<li><a href="http://nar.oxfordjournals.org/search?author1=Annamaria+Carissimo&amp;sortspec=date&amp;submit=Submit">Annamaria Carissimo</a><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-1" id="xref-aff-1-2"><sup>1</sup></a>,<a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#corresp-3" id="xref-corresp-3-2"><sup>&dagger;</sup></a>,&nbsp;</li>
	<li><a href="http://nar.oxfordjournals.org/search?author1=Luisa+Cutillo&amp;sortspec=date&amp;submit=Submit">Luisa Cutillo</a><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-1" id="xref-aff-1-3"><sup>1</sup></a>,<a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-2" id="xref-aff-2-1"><sup>2</sup></a>,<a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#corresp-3" id="xref-corresp-3-3"><sup>&dagger;</sup></a>,&nbsp;</li>
	<li><a href="http://nar.oxfordjournals.org/search?author1=Ching-Hung+Lai&amp;sortspec=date&amp;submit=Submit">Ching-Hung Lai</a><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-1" id="xref-aff-1-4"><sup>1</sup></a>,<a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#corresp-3" id="xref-corresp-3-4"><sup>&dagger;</sup></a>,&nbsp;</li>
	<li><a href="http://nar.oxfordjournals.org/search?author1=Margherita+Mutarelli&amp;sortspec=date&amp;submit=Submit">Margherita Mutarelli</a><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-1" id="xref-aff-1-5"><sup>1</sup></a>,<a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#corresp-3" id="xref-corresp-3-5"><sup>&dagger;</sup></a>,&nbsp;</li>
	<li><a href="http://nar.oxfordjournals.org/search?author1=Maria+Nicoletta+Moretti&amp;sortspec=date&amp;submit=Submit">Maria Nicoletta Moretti</a><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-1" id="xref-aff-1-6"><sup>1</sup></a>,<a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#corresp-3" id="xref-corresp-3-6"><sup>&dagger;</sup></a>,&nbsp;</li>
	<li><a href="http://nar.oxfordjournals.org/search?author1=Marwah+Veer+Singh&amp;sortspec=date&amp;submit=Submit">Marwah Veer Singh</a><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-1" id="xref-aff-1-7"><sup>1</sup></a>,&nbsp;</li>
	<li><a href="http://nar.oxfordjournals.org/search?author1=Marianthi+Karali&amp;sortspec=date&amp;submit=Submit">Marianthi Karali</a><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-1" id="xref-aff-1-8"><sup>1</sup></a>,&nbsp;</li>
	<li><a href="http://nar.oxfordjournals.org/search?author1=Diego+Carrella&amp;sortspec=date&amp;submit=Submit">Diego Carrella</a><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-1" id="xref-aff-1-9"><sup>1</sup></a>,&nbsp;</li>
	<li><a href="http://nar.oxfordjournals.org/search?author1=Mariateresa+Pizzo&amp;sortspec=date&amp;submit=Submit">Mariateresa Pizzo</a><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-1" id="xref-aff-1-10"><sup>1</sup></a>,&nbsp;</li>
	<li><a href="http://nar.oxfordjournals.org/search?author1=Francesco+Russo&amp;sortspec=date&amp;submit=Submit">Francesco Russo</a><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-3" id="xref-aff-3-1"><sup>3</sup></a>,&nbsp;</li>
	<li><a href="http://nar.oxfordjournals.org/search?author1=Stefano+Ferrari&amp;sortspec=date&amp;submit=Submit">Stefano Ferrari</a><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-4" id="xref-aff-4-1"><sup>4</sup></a>,&nbsp;</li>
	<li><a href="http://nar.oxfordjournals.org/search?author1=Diego+Ponzin&amp;sortspec=date&amp;submit=Submit">Diego Ponzin</a><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-4" id="xref-aff-4-2"><sup>4</sup></a>,&nbsp;</li>
	<li><a href="http://nar.oxfordjournals.org/search?author1=Claudia+Angelini&amp;sortspec=date&amp;submit=Submit">Claudia Angelini</a><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-3" id="xref-aff-3-2"><sup>3</sup></a>,&nbsp;</li>
	<li><a href="http://nar.oxfordjournals.org/search?author1=Sandro+Banfi&amp;sortspec=date&amp;submit=Submit">Sandro Banfi</a><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-1" id="xref-aff-1-11"><sup>1</sup></a>,<a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-5" id="xref-aff-5-1"><sup>5</sup></a>,<a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#corresp-2" id="xref-corresp-2-1">*</a>&nbsp;and&nbsp;</li>
	<li><a href="http://nar.oxfordjournals.org/search?author1=Diego+di%C2%A0Bernardo&amp;sortspec=date&amp;submit=Submit">Diego di&nbsp;Bernardo</a><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-1" id="xref-aff-1-12"><sup>1</sup></a>,<a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#aff-6" id="xref-aff-6-1"><sup>6</sup></a>,<a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#corresp-1" id="xref-corresp-1-1">*</a></li>
</ol>

<p><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#">-</a>Author Affiliations</p>

<ol>
	<li><a id="aff-1" name="aff-1"></a>

	<address><sup>1</sup>Telethon Institute of Genetics and Medicine (TIGEM), Via Campi Flegrei 34, 80078 Pozzuoli, Italy</address>
	</li>
	<li><a id="aff-2" name="aff-2"></a>
	<address><sup>2</sup>Dipartimento Studi Aziendali e Quantitativi (DISAQ), Universit&agrave; degli studi di Napoli &lsquo;Parthenope&rsquo;, Via Generale Parisi, 80132 Napoli, Italy</address>
	</li>
	<li><a id="aff-3" name="aff-3"></a>
	<address><sup>3</sup>Istituto per le Applicazioni del Calcolo, Consiglio Nazionale delle Ricerca, Via Pietro Castellino 111, 80131 Napoli, Italy</address>
	</li>
	<li><a id="aff-4" name="aff-4"></a>
	<address><sup>4</sup>Fondazione Banca degli Occhi del Veneto, Via Paccagnella 11, 30174 Zelarino (Venice), Italy</address>
	</li>
	<li><a id="aff-5" name="aff-5"></a>
	<address><sup>5</sup>Medical Genetics, Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, via Luigi De Crecchio 7, 80138 Naples (NA), Italy</address>
	</li>
	<li><a id="aff-6" name="aff-6"></a>
	<address><sup>6</sup>Dept. Of Chemical, Materials and Industrial Production Engineering, University of Naples &lsquo;Federico II&rsquo;, Piazzale Tecchio 80, 80125 Naples, Italy</address>
	</li>
</ol>

<p><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#">+</a>Author Notes</p>

<ol>
	<li><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#xref-corresp-1-1">&crarr;</a>*To whom correspondence should be addressed.&nbsp;Tel: +39 81 192 30 600; Fax: +39 81 192 30 651; Email:&nbsp;<a href="mailto:dibernardo@tigem.it">dibernardo@tigem.it</a></li>
	<li><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#xref-corresp-2-1">&crarr;</a>Correspondence may also be addressed to Sandro Banfi.&nbsp;Tel: +39 81 192 30 600; Fax: +39 81 192 30 651; Email:&nbsp;<a href="mailto:banfi@tigem.it">banfi@tigem.it</a></li>
	<li><a href="http://nar.oxfordjournals.org/content/early/2016/05/27/nar.gkw486.full#xref-corresp-3-1">&crarr;</a>&dagger;These authors contributed equally to this work as the first authors.</li>
</ol>