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diff --git a/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/acknowledgment.rtf b/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/acknowledgment.rtf new file mode 100644 index 0000000..24f8c40 --- /dev/null +++ b/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/acknowledgment.rtf @@ -0,0 +1 @@ +<p>The authors wish to acknowledge technical assistance from: D. Godfrey, S. Lionikaite, V. Lionikaite, A.S. Lionikiene and J. Zekos as well as technical and intellectual input from M. Abney, J. Borevitz, K. Broman, N. Cai, R. Cheng, N. Cox, R. Davies, J. Flint, L. Goodstadt, P. Grabowski, B. Harr, E. Leffler, R. Mott, J. Nicod, J. Novembre, A. Price, M. Stephens, D. Weeks and X. Zhou. This project was funded by NIH R01GM097737 and P50DA037844 (A.A.P.), NIH T32DA07255 (C.C.P.), NIH T32GM07197 (N.M.G.), NIH R01AR056280 (D.A.B.), NIH R01AR060234 (C.L.A.-B.), the Fellowship from the Human Frontiers Science Program (P.C.) and the Howard Hughes Medical Institute (J.K.P.).</p>
diff --git a/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/cases.rtf b/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/cases.rtf new file mode 100644 index 0000000..97eed8a --- /dev/null +++ b/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/cases.rtf @@ -0,0 +1,3 @@ +<p>Phenotype, genotype and RNA-seq gene expression data is available at</p>
+
+<p>http://datadryad.org/resource/doi:10.5061/dryad.2rs41</p>
diff --git a/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/processing.rtf b/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/processing.rtf new file mode 100644 index 0000000..9c368fa --- /dev/null +++ b/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/processing.rtf @@ -0,0 +1 @@ +<p>FPKM data were quantitle normalized for each ENSEMBL gene (mRNA) model (Identifiers such as ENSMUSG00000093778). Every gene/mRNA therefore has a mean expression value of 0 and a perfectly normal distribution, even if the original distribution was bimodal. The QQ plots is GN will be straight lines. There is no data at all on expression level in this original data set downloaded from <a href="http://dx.doi.org/10.5061/dryad.2rs41">http://dx.doi.org/10.5061/dryad.2rs41</a></p>
diff --git a/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/specifics.rtf b/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/specifics.rtf new file mode 100644 index 0000000..30656c6 --- /dev/null +++ b/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/specifics.rtf @@ -0,0 +1 @@ +Prefrontal Cortex
\ No newline at end of file diff --git a/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/summary.rtf b/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/summary.rtf new file mode 100644 index 0000000..0639fe7 --- /dev/null +++ b/general/datasets/UCSD_CFW_PFC_RNA_Seq_0117/summary.rtf @@ -0,0 +1 @@ +<p>Although mice are the most widely used mammalian model organism, genetic studies have suffered from limited mapping resolution due to extensive linkage disequilibrium (LD) that is characteristic of crosses among inbred strains. Carworth Farms White (CFW) mice are a commercially available outbred mouse population that exhibit rapid LD decay in comparison to other available mouse populations. We performed a genome-wide association study (GWAS) of behavioral, physiological and gene expression phenotypes using 1,200 male CFW mice. We used genotyping by sequencing (GBS) to obtain genotypes at 92,734 SNPs. We also measured gene expression using RNA sequencing in three brain regions. Our study identified numerous behavioral, physiological and expression quantitative trait loci (QTLs). We integrated the behavioral QTL and eQTL results to implicate specific genes, including Azi2 in sensitivity to methamphetamine and Zmynd11 in anxiety-like behavior. The combination of CFW mice, GBS and RNA sequencing constitutes a powerful approach to GWAS in mice. <a href="http://genenetwork.org/dbdoc/ng_3609_cfw_outbred_gwas.pdf">Full article available here</a>.</p>
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