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Diffstat (limited to 'general/datasets/Jax_d2_mono2vpbmc_ret_rna_seq_0619/experiment-design.rtf')
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diff --git a/general/datasets/Jax_d2_mono2vpbmc_ret_rna_seq_0619/experiment-design.rtf b/general/datasets/Jax_d2_mono2vpbmc_ret_rna_seq_0619/experiment-design.rtf new file mode 100644 index 0000000..1c50734 --- /dev/null +++ b/general/datasets/Jax_d2_mono2vpbmc_ret_rna_seq_0619/experiment-design.rtf @@ -0,0 +1 @@ +<p>To understand the function of these infiltrating monocyte-like cells, we used RNA-sequencing to profile their transcriptomes. Based on their pro-inflammatory molecular signatures, we hypothesized and confirmed that monocyte-platelet interactions occur in glaucomatous tissue. Furthermore, to test monocyte function we used two approaches to inhibit their entry into the optic nerve head: (1) treatment with DS-SILY, a peptidoglycan that acts as a barrier to platelet adhesion to the vessel wall and to monocytes, and (2) genetic targeting of Itgam (CD11b, an immune cell receptor that enables immune cell extravasation).</p>
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