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diff --git a/general/brand/aging/home.md b/general/brand/aging/home.md index 33c18e1..17ca578 100644 --- a/general/brand/aging/home.md +++ b/general/brand/aging/home.md @@ -1,5 +1,14 @@ -New aging portal! This is initial work for providing a full community webservice for aging. +New UMHET3 and aging portal! This is initial work for providing a full community webservice for aging. +- [https://doi.org/10.1101/2025.04.27.649857](https://doi.org/10.1101/2025.04.27.649857). +**Genetic Modulation of Lifespan: Dynamic Effects, Sex Differences, and Body Weight Trade-offs** -This is a stub until David edits it! Or Rob. See this link to [edit](https://github.com/genenetwork/gn-docs/edit/master/general/brand/aging/home.md). +> **Abstract**: The dynamics of lifespan are shaped by DNA variants that exert effects at different ages. We have mapped genetic loci that modulate age-specific mortality using an actuarial approach. We started with an initial population of 6,438 pubescent siblings and ended with a survivorship of 559 mice that lived to at least 1100 days. Twenty-nine Vita loci dynamically modulate the mean lifespan of survivorships with strong age- and sex-specific effects. Fourteen have relatively steady effects on mortality while other loci act forcefully only early or late in life and with polarities of effects that invert. A distinct set of 19 Soma loci shape the negative correlation between weights of young adults with their life expectancies—much more strongly so in males than females. Another set of 11 Soma loci shape the positive correlation between weights at older ages with life expectancies. The Vita and Soma loci share 289 age-dependent epistatic interactions (LODs ≥3.8) but fewer than 4% are common to both sexes. [More...](https://doi.org/10.1101/2025.04.27.649857). -For markdown check [the docs](https://commonmark.org/help/). To embed images you can use a link somewhere from the internet or check it into the gn-doc repo and I'll add a link. +We provide two examples of how to move from maps toward potential mechanisms. Our findings provide an empirical bridge between evolutionary theories on aging and genetic and molecular causes. These loci and their interactions are key to begin to understand the impact of interventions that may extend healthy lifespan in mice and even in humans. + + + +- Data files are available [here](https://files.genenetwork.org/current/umhet3_2025/). +- Code is available at [https://github.com/DannyArends/UM-HET3/](https://github.com/DannyArends/UM-HET3/) + +See also GeneNetwork.org [examples on aging](https://aging.genenetwork.org/). diff --git a/general/brand/aging/um-het3.png b/general/brand/aging/um-het3.png new file mode 100644 index 0000000..5c762ce --- /dev/null +++ b/general/brand/aging/um-het3.png Binary files differ |
