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-<p>This April 2005 data set provides estimates of mRNA expression in normal kidneys of 32 strains of rats. The set includes the hypertensive SHR strain, the normotensive BN strain, and 30 HXB/BXH recombinant inbred strains. Each strain was sampled in quadruplicate (6-week-old males). Animals and tissues were generated by Michal Pravenec and colleagues at the Czech Academy of Sciences (CAS). RNA samples were processed at the Max-Delbr&uuml;ck-Center (MDC), Berlin Buch by <a class="fs14" href="http://www.mdc-berlin.de/englisch/research/e_index.htm" target="_blank">Nobert H&uuml;bner</a> and colleagues. Transcriptome mapping was carried out by Timothy Aitman and colleagues at the Imperial College, London (ICL). Samples were hybridized individually to a total of 128 Affymetrix RAE230A array. This particular data set includes 120 arrays processed using a quantile normalized variant of the Affymetrix MAS5 protocol. The expression values of each array have been logged and adjusted to a mean of 8 and a stardard deviation of 2 (mean and variance stabilized). This data set complements the original MAS5 data set exploited by H&uuml;bner and colleagues <a class="fs14" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=15711544" target="_blank">2005</a>. <a class="fs14" href="./array_data/Rat_230A_Kidney/Transform/KI_2A_0405_M.xls">Download</a> the particular transform in an Excel work book with both strain means and SEMs.</p>

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-<p>These data can also be viewed using the <a class="fs14" href="http://web.bioinformatics.ic.ac.uk/eqtlexplorer/" target="_blank">eQTL Explorer</a> Java application by John Mangion, Tim Aitman, and colleagues (Mueller et al. <a class="fs14" href="http://bioinformatics.oxfordjournals.org/cgi/reprint/btk007v1.pdf

-" target="_blank">2006</a>).</p>

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-<p><a href="http://www.ncbi.nlm.nih.gov/pubmed/19112506" target="_blank">Genome-wide co-expression analysis in multiple tissues.</a></p>

-

-<p>And see closely associate set of papers:</p>

-

-<ol>

-	<li><a href="http://www.ncbi.nlm.nih.gov/pubmed/15711544" target="_blank">Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease.</a></li>

-	<li><a href="http://www.ncbi.nlm.nih.gov/pubmed/17054398" target="_blank">Heritability and tissue specificity of expression quantitative trait loci.</a></li>

-	<li><a href="http://www.ncbi.nlm.nih.gov/pubmed/18443592" target="_blank">Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass.</a></li>

-	<li><a href="http://www.ncbi.nlm.nih.gov/pubmed/20386736" target="_blank">New insights into the genetic control of gene expression using a Bayesian multi-tissue approach.</a></li>

-	<li><a href="http://www.ncbi.nlm.nih.gov/pubmed/20430781" target="_blank">The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance.</a></li>

-	<li><a href="http://www.ncbi.nlm.nih.gov/pubmed/20827270" target="_blank">A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.</a></li>

-	<li><a href="http://www.ncbi.nlm.nih.gov/pubmed/21846806" target="_blank">Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat.</a></li>

-	<li><a href="http://www.ncbi.nlm.nih.gov/pubmed/23118132" target="_blank">Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans.</a></li>

-</ol>