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| author | Bonface | 2024-02-09 09:41:28 -0600 |
|---|---|---|
| committer | Munyoki Kilyungi | 2024-08-09 13:30:43 +0300 |
| commit | d029d5d7f8ead1f1de8d318045004a4a6f68f5fb (patch) | |
| tree | 33c7ff40e3f953d030ed08f468f7afb1dfcba9e6 /general/datasets/JAX_D2_Mono2vPBMC_Ret_RNA_Seq_0619/experiment-design.rtf | |
| parent | 769ff7825f5d8d36d541e90534c07f1985899973 (diff) | |
| download | gn-docs-d029d5d7f8ead1f1de8d318045004a4a6f68f5fb.tar.gz | |
Update dataset RTF Files.
Diffstat (limited to 'general/datasets/JAX_D2_Mono2vPBMC_Ret_RNA_Seq_0619/experiment-design.rtf')
| -rw-r--r-- | general/datasets/JAX_D2_Mono2vPBMC_Ret_RNA_Seq_0619/experiment-design.rtf | 1 |
1 files changed, 1 insertions, 0 deletions
diff --git a/general/datasets/JAX_D2_Mono2vPBMC_Ret_RNA_Seq_0619/experiment-design.rtf b/general/datasets/JAX_D2_Mono2vPBMC_Ret_RNA_Seq_0619/experiment-design.rtf new file mode 100644 index 0000000..1c50734 --- /dev/null +++ b/general/datasets/JAX_D2_Mono2vPBMC_Ret_RNA_Seq_0619/experiment-design.rtf @@ -0,0 +1 @@ +<p>To understand the function of these infiltrating monocyte-like cells, we used RNA-sequencing to profile their transcriptomes. Based on their pro-inflammatory molecular signatures, we hypothesized and confirmed that monocyte-platelet interactions occur in glaucomatous tissue. Furthermore, to test monocyte function we used two approaches to inhibit their entry into the optic nerve head: (1) treatment with DS-SILY, a peptidoglycan that acts as a barrier to platelet adhesion to the vessel wall and to monocytes, and (2) genetic targeting of Itgam (CD11b, an immune cell receptor that enables immune cell extravasation).</p>
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