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{
"titles": [
"2004 - Diabetes Genes a.pdf",
"2015 - Recent Trends in Therapeutic Approaches for Diabetes Management A Comprehensive Updat.pdf",
"2010 - The Genetics of Type 2 Diabetes.pdf",
"2015 - Recent Trends in Therapeutic Approaches for Diabetes Management A Comprehensive Updat.pdf",
"2018 - A theoretical framework for interaction of nursing discipline.pdf",
"2015 - Recent Trends in Therapeutic Approaches for Diabetes Management A Comprehensive Updat.pdf",
"2005 - Animal models of diabetes mellitus.pdf",
"2017 - Painting a new picture of personalised medicine for diabetes.pdf",
"2015 - Recent Trends in Therapeutic Approaches for Diabetes Management A Comprehensive Updat.pdf",
"2015 - Recent Trends in Therapeutic Approaches for Diabetes Management A Comprehensive Updat.pdf"
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"unraveling the pathophysiological mechanisms of this disease, identifying candidate diabetic genes, and discovering and testing new therapeutic agents. The classical rodent models of diabetes allow unbiased discovery, while the new models made by genetic manipulation allow testing of the role of specific genes and tissues. Experimental animal models are an irreplaceable resource for diabetes research and are hastening the progress towards the goals of better treatment, prevention, and cure.",
"is absence of reliable methods for generating specific celltypes,immunologicalrejectionofthetransplantedcells,anddifficulty in purification of specific lineages [55]. Furtherconcernsincludetheuncontrolledproliferationofthetrans-planted embryonic stem cells into a specific type, once theyaretransplanted[56].Still,despiteofitsmanifoldlimitationsboth scientific and ethical, the application of stem cell tech-nologyholdsimmenseprospectsintreatmentofdiabetes. 6. Gene Therapy in Diabetes",
"T ogether, these discoveries will continue to improve our understanding of the biologic mechanisms that maintain glucose homeostasis, and of still hidden molecular defects leading to chronic hyperglycemia, and could also lead to the development of more speci cally targeted antidiabetic drugs or even gene - based therapies. Moreover, pharmacogenetic testing might then be used to predict, for each patient, the therapeutic response to different classes of drugs. The identi cation of T2DM genes will",
"Greatstrideshavebeenmadeclinicallyintheprevention, development,andtreatmentofthediseasebutnotherapeuticmethod have been completely successful till date. With newtechnologies revolutionizing the treatment possibilities, thesearch for an effective medication is not far ahead. Theextensive research leading to the discovery of the pathwaygenes contributing to the development of the disease andthe sequencing of complete genomes have revolutionized the diabetes research. The development of the techniques",
"into different genetic levels of disease categories, from which pre- vention or treatment methods could be provided accordingly [ 4]. For example, some forms of diabetes are directly related to a change in a single gene [ 34]. Some patients who are diagnosed with type 1 diabetes can now be tested for one of monogenic diabetes. The appropriate treatment for these patients is not injecting insulin, but giving oral sulfonylureas [ 34]. Moreover, it is now well understood",
"pp .430435,2003. [58] M. Zalzman, S. Gupta, R. K. Giri et al., Reversal of hyperglycemia in mice by using human expandable insulin- producing cells differentiated from fetal liver progenitor cells,Proceedings of the National Academy of Sciences of the United StatesofAmerica ,vol.100,no .12,pp .72537258,2003. [59] H.-S. Jun and J.-W. Yoon, Approaches for the cure of type 1 diabetes by cellular and gene therapy, Current Gene Therapy , vol.5,no.2,pp.249262,2005.",
"transgenics. It is likely that animal models will play an importantrole in the eventual cure of human diabetes mellitus. Competing interests None declared. References 1Sima AAF, Shafrir E, eds. Animal Models of Diabetes: A Primer. Amsterdam: Harwood Academic Publishers, 2000. 2British Union for the Abolition of Vivisection. Home page. Available from: http://www.buav.org. 3Patterson C. Eternal Treblinka. Our Treatment of Animals and the Holocaust . New York: Lantern Books, 2002. 4Regan T.",
"Third, this view of diabetes pathogenesis is consistent with the growing portfolio of available therapies. We have agents and interventions that can prevent or ameliorate diabetesthrough, for example, beneficial effects on islet function (e.g. sulfonylureas), obesity (weight loss), insulin resistance (e.g. exercise), fuel partitioning (e.g. thiazolidinediones) andmicrobiome content (metformin, possibly). Just as diabetes risk alleles influence metabolic phenotype through pushing",
"aprospectivetherapeuticapproachfortype1diabetes[59]. Thein vivogene therapy is the method of choice as a therapeutic strategy because it is simpler and the vectorcontaining the desired gene is directly inserted into thepatient, but the development of safe (not toxic to host)and effective vectors remains as a challenging task for genetherapist. Presently, the strategies for in vivotherapy involve",
"betacellulin gene therapy induces islet neogenesis in the liver a n dr e v e r s e sd i a b e t e si nm i c e , Nature Medicine ,v o l .9 ,n o .5 , pp.596603,2003. [73] S. Ferber, A. Halkin, H. Cohen et al., Pancreatic and duode- nal homeobox gene 1 induces expression of insulin genes inliver and ameliorates streptozotocin-induced hyperglycemia, Nature Medicine ,vol.6,no .5,pp .568572,2000. [74] P.A.Halban,S.E.Kahn, A.Lernmark,andC.J.Rhodes,Gene andcell-replacementtherapyinthetreatmentoftype1diabetes."
],
"answer": "New gene therapies have the potential to cure or treat diabetes through several innovative approaches: 1. **Gene-Based Therapies**: Advances in understanding the biological mechanisms that maintain glucose homeostasis and the molecular defects leading to chronic hyperglycemia could lead to the development of gene-based therapies. These therapies aim to target specific genetic factors involved in diabetes, potentially offering more precise treatment options [3]. 2. **In Vivo Gene Therapy**: This approach involves directly inserting a vector containing the desired gene into the patient. It is considered a promising therapeutic strategy for type 1 diabetes, although challenges remain in developing safe and effective vectors [9]. 3. **Inducing Islet Neogenesis**: Gene therapy techniques, such as betacellulin gene therapy, have been shown to induce islet neogenesis in the liver and reverse diabetes in mice. This suggests that gene therapy can stimulate the body to produce insulin-producing cells, offering a potential cure for diabetes [10]. These strategies highlight the potential of gene therapies to address the underlying genetic causes of diabetes and restore normal insulin production and glucose regulation.",
"question": "How can new gene therapies potentially cure or treat diabetes?"
}
|
