1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
|
{
"titles": [
"2001 - Demography in the age of genomics.pdf",
"2012 - Genome-Environment Interactions That Modulate.pdf",
"2020 - Protecting the Aging Genome.pdf",
"2012 - Peroxiredoxins, gerontogenes linking.pdf",
"2019 - Genomics of 1 million parent lifespans.pdf",
"2021 - Epigenetics of Aging and Aging-Associated Diseases.pdf",
"2012 - Genome-Environment Interactions That Modulate.pdf",
"2020 - Clinical Genetics and Genomics of Aging.pdf",
"2012 - Aging, Rejuvenation, and Epigenetic.pdf",
"2016 - Progress on the role of DNA methylation in aging.pdf"
],
"extraction_id": [
"e3014138-3d5b-58bc-a1a5-5ac6f04cac1c",
"68b12e10-d643-570a-aa63-eda62de81928",
"e5067ce2-69a6-5433-bed4-b95daeaa691e",
"38ebdc6a-8e8e-5472-a3ed-9a0f06591474",
"ff0adc7c-70ff-5b14-ba7d-a9dda60fac80",
"e2bc9b8e-2349-509b-a148-fbd86f0455f4",
"8650652a-1765-563b-a98e-2e9336bcf29a",
"822571e2-b05d-5e17-9eaa-431151851111",
"b9f038dd-97af-51ea-bb32-d73bf66c3dcb",
"8829c724-73ff-582b-ab94-c9f1a906cfd5"
],
"document_id": [
"0f07fa43-feb6-5656-b7e7-b8faa86f5623",
"b1a1997c-e9df-5dc0-9d12-a3977d0c64ec",
"bb774030-2570-5596-b2ab-b8f57ff81086",
"2eaad7ba-b6ae-5382-ba79-84609080b53e",
"f68b939c-847b-5eac-8926-24713ae43478",
"70945353-4808-539a-80f9-5632c27913e5",
"b1a1997c-e9df-5dc0-9d12-a3977d0c64ec",
"62b635c3-040e-512a-b016-6ef295308a1e",
"bde26feb-f423-51b0-89ec-6f079bfc8b17",
"e4cdc02f-4415-5638-aab8-f848b4d64a22"
],
"id": [
"chatcmpl-AIFhM7HonwMIv1KCdMHKw9gGzAYlV",
"9da7c5dc-0deb-577c-bb22-83f987bd76dd",
"78733c6a-d870-5154-9128-eb66291fa967",
"3c636897-c47e-505d-9203-306124b73e0e",
"43cba086-7f03-529f-bcd0-6483202bf3c7",
"de7c30f6-cce9-563d-83f4-809f2aab781b",
"4eb34c07-921b-55bb-98eb-ff013bb2ace0",
"f20fd517-5f05-53ca-93a5-916bc891ad92",
"265126e3-2a4d-518f-93cf-21a201747eef",
"afc304d1-dd43-55ec-811d-27ca27fc4e5d",
"1c77b8dc-2fd6-5e3d-9cf0-5585e7c9fb57"
],
"contexts": [
"raises the possibility of therapies to slow aging. Therefore the discoveryof a gerontogene with even very rare mutations that increased longevitywould cause speculation about future trends in mortality. However, thediscovery of such a gene would be relevant only to long-term (and, there-fore, very speculative) projections. Prospective Epidemiologic Surveys that Include Genetic Information Some epidemiologic cohort studies of populations have collected",
"need to develop approaches and therapies targeting theaging process and age-related diseases (Butler et al.,2008). Delaying the process of aging, even slightly,would have profound social, medical and economic ben-efits (Olshansky et al., 2006; Butler et al., 2008). Forexample, slowing aging by a mere 7 years would cutmortality of age-related diseases by half at every age.Therefore, the potential benefits from research on thebasic biology and genetics of aging are unparalleled interms of improving quality",
"Interestingly, when senescent cells are abolished either through genetic manipulation or via senolytic drugs, biological aging is signicantly halted in mice [ 53,54]. Therefore, trials are now under way to test the ability of senolytics to postpone age-associated pathologies in humans [ 55]. Notably, multi- ple drugs are being pursued that either directly or indirectly impact DNA repair or the consequenceof DNA damage. Future Prospects: Developing Interventions through DNA Repair",
"and potentially important genetic markers for slow aging have been found in humans (Suh et al. 2008). Elucidating the function of such genes is believed to enable decipher- ing the core of the aging process, answer to what extentthe process is conserved, and pave the way for therapeutic interventions of age-related maladies, including cancers, neurodegeneration, and metabolic syndrome (Guarente 2011). The identity of the virtual gerontogenes so far discov-",
"discover specific genes that directly influence how quickly people age, beyond diseases. If such genes exist, their effects were too small to be detected in this study. The next step will be to expand the study to include more participants, which will hopefully pinpoint further genomic regions and help disentangle the biology of ageing and disease. DOI: https://doi.org/10.7554/eLife.39856.002",
"using bulk mRNA or even analyzing single cells (scRNA-seq). In addition, advances in molecular biology and cell culture approaches (for instance Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9) will be benecial in clarifying aging-processes across species. An improved understanding of epigenetic mechanisms affecting longevity will be deciding crucial step towards the identication of new potential therapeutic targets. In",
"century. Manipulation of aging-related genes by diet,lifestyle, and pharmaceuticals could dramatically im-prove human health and could be used to develop drugsagainst age-related diseases such as cancer, heart dis-ease, type 2 diabetes, obesity, and neurodegenerativediseases. The hundreds of aging-related genes and genesrelated to CR already identified offer enormous oppor-tunities for target discovery (Fig. 2). Although aging-related genes cannot be modified in humans, under-standing how these can be",
"5. Goldman DP, etal. Substantial health and economic returns from delayed aging may warrant a new focus for medical research. Health Aff (Millwood). 2013;32(10):1698705. 6. Esplin ED, Oei L, Snyder MP.Personalized sequencing and the future of medicine: discov- ery, diagnosis and defeat of disease. Pharmacogenomics. 2014;15(14):177190. 7. Marian AJ.Clinical applications of molecular genetic discoveries. Transl Res. 2016;168:614.",
"a medical intervention), without changing the fundamental rateof organismal aging. Nevertheless, it does seem that manyso-called longevity genes, as well as dietary restriction, appear to extend not only life span, but also health span (Kauffman et al., 2010; Luo et al., 2010 ). In that regard, it does appear that it is possible to experimentally slow the rate of aging. Still, in each case, aging does continue on as if there is some",
"genetic modification. Currently, emerging evidence suggeststhat certain interventions (e.g. CR, dietary supplementation andchemical drugs) can prevent age-related diseases and promote longevity, at least in part, through reversing the aberrant age- associated changes in DNA methylation, suggesting the greatpotential of DNA methylation in therapeutic strategies againstage-related diseases ( Figure 1B ).However, to further understand the roles of DNA methyla-"
],
"answer": "Yes, genetic research can potentially lead to treatments that slow down aging. Several pieces of evidence from the context support this possibility: 1. The discovery of genetic markers for slow aging in humans suggests that understanding these genes could pave the way for therapeutic interventions for age-related maladies, including cancers, neurodegeneration, and metabolic syndrome [4]. 2. Research indicates that manipulating aging-related genes through various means, such as diet, lifestyle, and pharmaceuticals, could dramatically improve human health and lead to the development of drugs against age-related diseases [7]. 3. Advances in molecular biology, such as CRISPR/Cas9, are expected to clarify aging processes and identify new potential therapeutic targets, which could be crucial for developing treatments that slow aging [6]. 4. The use of senolytic drugs, which target senescent cells, has shown promise in halting biological aging in mice, and trials are underway to test their effectiveness in humans [3]. 5. There is a suggestion that interventions targeting DNA methylation and other genetic modifications could prevent age-related diseases and promote longevity, highlighting the potential of genetic research in developing therapeutic strategies against aging [10]. Overall, while the research is still ongoing and some findings are speculative, there is significant potential for genetic research to contribute to treatments that slow down the aging process.",
"question": "Can genetic research lead to treatments that slow down aging?"
}
|
