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+{
+  "titles": [
+    "2017 - Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism.pdf",
+    "2021 - Gene-by-environment modulation of lifespan and weight gain in the murine BXD family.pdf",
+    "2012 - Aging, Rejuvenation, and Epigenetic.pdf",
+    "2016 - The dog aging project translational geroscience in companion.pdf",
+    "2012 - Aging, Rejuvenation, and Epigenetic.pdf",
+    "2020 - Mitonuclear genomics and aging.pdf",
+    "2021 - Epigenetics of Aging and Aging-Associated Diseases.pdf",
+    "2017 - Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism.pdf",
+    "2021 - Gene-by-environment modulation of lifespan and weight gain in the murine BXD family.pdf",
+    "2012 - Genome-Environment Interactions That Modulate.pdf"
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+    "Dietary interventions, including starvation and protein deprivation, can also alter patterns of DNA methyla- tion, potentially in a long-lasting manner [42, 43], including transgenerationally [26, 44]. Dietary, genetic and pharmacological interventions that improve health during aging and extend lifespan induce long-lasting changes in gene expression that mediate their effects. Here we have asked if and how age-related DNA methylation, transcription and lipid",
+    "Longev. Heal. 2, 10 (2013). 7. Kreienkamp Ret al.Doubled lifespan and patient-like pathologies in progeria mice fed high-fat diet.  Aging Cell18, e12852 (2019). [PubMed: 30548460]  8. Heilbronn LK & Ravussin E Calorie restriction and aging: review of the literature and implications  for studies in humans. Am. J. Clin. Nutr. 78, 361369 (2003). [PubMed: 12936916]  9. Liang Yet al.Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of",
+    "a medical intervention), without changing the fundamental rateof organismal aging. Nevertheless, it does seem that manyso-called longevity genes, as well as dietary restriction, appear to extend not only life span, but also health span (Kauffman et al., 2010; Luo et al., 2010 ). In that regard, it does appear that it is possible to experimentally slow the rate of aging. Still, in each case, aging does continue on as if there is some",
+    "As we describe above, a small but growing number ofinterventions has been shown to reproducibly increase lifespan in laboratory animals and, in a few cases, to also delay or reverse age-related declines in multiple organsystems. These healthy aging interventions could, in prin- ciple, be tested to determine whether they also increase lifespan and promote healthspan in dogs (Table 1). There are several questions that immediately present themselves when considering the design of a healthy aging interven-",
+    "be linked to the biology of stem cell quiescence and self-renewal. Although genetic and environmental interventions have clearly proven to be effective in prolonging life span, we postulate thatthose interventions, as well as the rejuvenating interventions described above, are, in fact, acting primarily to modify theepigenome. Consistent with this, genetic interventions directlytargeting the epigenome can extend life span ( Greer et al., 2010 ). Studying aging and rejuvenation through the lens of",
+    "During the past century, remarkable progress has been  made in unveiling the mechanisms of aging. Genetic and molecular pathways that regulate healthspan and lifespan have been identified in various model organisms, provid-ing a rich knowledge base (Longo etal. 2015; Lopez-Otin etal. 2013, 2016; Singh etal. 2019). However, the focus on",
+    "205. Li, Y.; Tollefsbol, T.O. p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic Mechanisms. PLoS ONE 2011 ,6, e17421. [CrossRef] 206. Daniel, M.; Tollefsbol, T.O. Epigenetic linkage of aging, cancer and nutrition. J. Exp. Biol. 2015 ,218, 5970. [CrossRef] 207. Kapahi, P .; Kaeberlein, M.; Hansen, M. Dietary restriction and lifespan: Lessons from invertebrate models. Ageing Res. Rev. 2017 , 39, 314. [CrossRef]",
+    "as diabetes, cancer and neurodegenerative disorders [1, 2]. Environmental and genetic interventions can ameliorate the effects of aging, with nutrition, nutrient-sensing signaling networks and metabolism playing evolutionarily conserved roles [1, 3 5]. Diet- ary restriction (DR), in which food intake is reducedwhile avoiding malnutrition, extends lifespan in di- verse model and non-model organisms [3, 6]. DR induces a remarkably broad-spectrum improvement in",
+    "53. Mair W & Dillin A Aging and survival: the genetics of life span extension by dietary restriction.  Annu. Rev. Biochem. 77, 727754 (2008). [PubMed: 18373439]  54. Masoro EJCaloric restriction-induced life extension of rats and mice: a critique of proposed  mechanisms. Biochim. Biophys. Acta1790, 10401048 (2009). [PubMed: 19250959]  55. Weindruch R, Walford RL, Fligiel S & Guthrie D The retardation of aging in mice by dietary",
+    "In addition to genes associated with aging, research has focused on identifying genes associated with the life- extending effects of CR. One method is to identify genesthat decrease or cancel out the life-extending effects of CRwhen mutated (Gems et al., 2002; Bishop and Guarente,2007). More than 100 such genes have been identified inmodel organisms (D. Wuttke, C. Vora, J. P. de Magalhes,unpublished observations). The growth hormone receptor(GHR) is the only gene so far identified in mammals that"
+  ],
+  "answer": "Yes, there are known lifestyle interventions that can positively impact genes related to aging. Dietary interventions, such as dietary restriction (DR) and calorie restriction, have been shown to alter patterns of DNA methylation and induce long-lasting changes in gene expression that improve health during aging and extend lifespan [1], [8]. These interventions can modify the epigenome, which is linked to the biology of aging [5]. Additionally, glucose restriction has been shown to extend human cellular lifespan through SIRT1-mediated epigenetic and genetic mechanisms [7].",
+  "question": "Are there any known lifestyle interventions that can positively impact genes related to aging?"
+}
+\ No newline at end of file