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diff --git a/gnqa/paper2_eval/data/dataset/domain_expert_aging_2 b/gnqa/paper2_eval/data/dataset/domain_expert_aging_2 new file mode 100644 index 0000000..c4e6321 --- /dev/null +++ b/gnqa/paper2_eval/data/dataset/domain_expert_aging_2 @@ -0,0 +1,65 @@ +{ + "titles": [ + "2015 - A Chromosome 13 locus is associated with male-specific mortality in mice.pdf", + "2021 - Footprints in the Sand Deep Taxonomic Comparisons in Vertebrate Genomics to Unveil the Genetic Programs of Human Longevity.pdf", + "2021 - Genetic loci and metabolic states associated with murine epigenetic aging.pdf", + "2021 -Mozhui- Epigenetic aging.pdf", + "2016 - Unraveling the message insights into comparative genomics.pdf", + "2012 - Chromatin Remodeling, DNA Damage Repair and Aging.pdf", + "2021 - Gene-by-environment modulation of lifespan and weight gain in the murine BXD family.pdf", + "2006 - THE GENETIC REGULATION OF THE RESPONSE OF HEMATOPOIETIC STEM_PROG.pdf", + "2012 - Genome-Scale Studies of Aging Challenges and Opportunities.pdf", + "2003 - Lifelong voluntary exercise in the mouse prevents.pdf" + ], + "extraction_id": [ + "5cc56e3b-53ab-5299-814d-014e2ed31d2f", + "11ca91fa-a13f-5cc5-90c8-53d1ebe76836", + "a9ebf1d8-5ef8-5c52-962e-110873476823", + "e662d80d-b529-5749-856c-ed734c6e3eaa", + "c6f50e80-1bc5-5b0a-b57b-4c2bfe524d96", + "d9a12bd9-c65e-547a-89aa-4e0231558ddc", + "30ba3324-6e19-58c2-9e32-508f827af3e5", + "c04cac81-a0b0-5d0a-b21e-2f94494bb302", + "9669b6fe-e9d7-55e8-a91a-c015df633daa", + "6a2cdf66-f3c9-5be9-b6b0-f203be169103" + ], + "document_id": [ + "ad8f2626-87fb-520e-8cef-ee9a9cc3ab0b", + "0dc45abe-ab02-5b07-9916-7093b53323c0", + "b82bd9e1-2373-577b-a942-164565eaca6b", + "d23daa43-4176-54e6-b3c3-b889843e92f1", + "0deba7bb-c27a-5d9e-b1b2-e48a5574882c", + "594e5dbe-b92a-5b0c-9f65-2a10670f9517", + "4d082da4-fa48-5170-8147-c4fea47a5d4b", + "b84914bc-195d-5c48-8e89-0db719675c1f", + "b77aace0-fa36-5fd4-8e2a-c8932198acd1", + "24d4f270-f45b-5830-84f9-b1e5bcd3c070" + ], + "id": [ + "chatcmpl-ABLwRFLcOLGvXJuXhHs6NCge9tY7Z", + "09da6f9e-b996-5438-91be-41d9438cb930", + "14bf5e8a-4095-536f-b98b-00c8cdae3a31", + "f8fdd2ee-710c-5d2c-8a70-bf48f4927653", + "e613d3df-adb0-56b0-abfd-8828020c23c3", + "02296a91-f1a4-5b35-a5d1-e1851797404b", + "90214d4d-4068-5490-9049-5604b5dcf3e2", + "56e03e38-0ae5-5b29-b929-662fa091e0ac", + "ebc5b444-a63f-5819-9d3a-ffbf96b3d367", + "80d01818-7573-5321-b33d-c7e291f3fe74", + "11af155f-85c6-5f8b-8943-5391ad678f7e" + ], + "contexts": [ + "11. Gelman R, Watson A, Bronson R et al (1988) Murine chromo- somal regions correlated with longevity. Genetics 118(4):693704 12. Jackson AU, Galecki AT, Burke DT et al (2002) Mouse loci associated with life span exhibit sex-specic and epistatic effects. J Gerontol A Biol Sci Med Sci 57(1):B9B15 13. Foreman JE, Lionikas A, Lang DH et al (2009) Genetic archi- tecture for hole-board behaviors across substantial time intervalsin young, middle-aged and old mice. Genes Brain Behav", + "Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. PLoS Genet. 14:e1007272. doi: 10.1371/journal.pgen.100 7272 Schchter, F., Faure-Delanef, L., Gunot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L., et al. (1994). Genetic associations with human longevity at the APOE and ACE loci. Nat. Genet. 6, 2932. doi: 10.1038/ng0194-29 Schinaman, J. M., Rana, A., Ja, W. W., Clark, R. I., and Walker, D. W. (2019).", + "of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin- like growth factor I levels and increased life span. Endocrinology 144:37993810. DOI: https://doi.org/10.1210/en. 2003-0374, PMID: 12933651 de Haan G, Williams RW. 2005. A genetic and genomic approach to identify longevity genes in mice. Mechanisms of Ageing and Development 126:133138. DOI: https://doi.org/10.1016/j.mad.2004.09.012, PMID: 15610771", + "of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin- like growth factor I levels and increased life span. Endocrinology 144:37993810. DOI: https://doi.org/10.1210/en. 2003-0374, PMID: 12933651 de Haan G, Williams RW. 2005. A genetic and genomic approach to identify longevity genes in mice. Mechanisms of Ageing and Development 126:133138. DOI: https://doi.org/10.1016/j.mad.2004.09.012, PMID: 15610771", + "Mulvey L, Sinclair A, Selman C (2014) Lifespan modulation in mice and the confounding effects of genetic background. J Genet Genomics 41:497503. doi: 10.1016/j.jgg.2014.06.002 OConnor TP, Lee A, Jarvis JUM, Buffenstein R (2002) Prolonged longevity in naked mole-rats: age-related changes in metabolism, body composition and gastrointestinal function. Comp Biochem Physiol A 133:835842. doi: 10.1016/S1095-6433(02)00198-8 Opazo JC, Palma RE, Melo F, Lessa EP (2005) Adaptive evolution of", + "/ mice by Lmna heterozy- gosity ameliorates progeroid phenotypes and extends lifespan [143, 174, 175].", + "References 1. Hook Met al.Genetic cartography of longevity in humans and mice: Current landscape and horizons. Biochim. Biophys. Acta1864, 27182732 (2018). 2. Kuningas Met al.Genes encoding longevity: from model organisms to humans. Aging Cell7, 270 280 (2008). [PubMed: 18208581] 3. de Magalhes JP, Wuttke D, Wood SH, Plank M & V ora C Genome-environment interactions that modulate aging: Powerful targets for drug discovery. Pharmacol. Rev. 64, 88101 (2012). [PubMed: 22090473]", + "\"Murine chromosomal regions correlated with longevity.\" Genetics 118: 693-704.", + "expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans . Aging Cell, 2009 , 8(4), 370-9. [73] Wang, H.D.; Kazemi-Esfarjani, P.; Benzer, S. Multiple-stress analysis for isolation of Drosophila longevity genes . Proc Natl Acad Sci U S A , 2004 , 101(34), 12610-5. [74] Lin, Y.J.; Seroude, L.; Benzer, S. Extended life-span and stress resistance in the Drosophila mutant methuselah . Science , 1998 , 282(5390), 943-6.", + "sion analysis of mouse liver genes: effect of age and of thelongevity mutant Prop1df. J Gerontol A Biol Sci Med Sci 56: B72B80, 2001. 12.Fabrizio P, Pozza F, Pletcher SD, Gendron CM, and Longo VD. Regulation of longevity and stress resistance by Sch9 in Yeast. Science 292: 288 290, 2001. 13.Haase D, Lehmann MH, Korner MM, Korfer R, Sigusch HH, and Figulla HR. Identi cation and validation of selective" + ], + "answer": "The mouse genes associated with longevity include: 1. **Mouse loci associated with life span**: These loci exhibit sex-specific and epistatic effects [1]. 2. **Mouse growth hormone receptor**: Alterations in this gene result in increased lifespan [3], [4]. 3. **Lmna heterozygosity**: This genetic modification ameliorates progeroid phenotypes and extends lifespan [6]. These references provide evidence of specific genes and loci in mice that have been linked to increased longevity.", + "question": "Which mouse genes have been associated with longevity?" +}
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