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diff --git a/gnqa/data/study2/lists/human-questions.json b/gnqa/data/study2/lists/human-questions.json new file mode 100644 index 0000000..4142e5b --- /dev/null +++ b/gnqa/data/study2/lists/human-questions.json @@ -0,0 +1,172 @@ +[ + { + "level": "domainexpert", + "domain": "gn", + "query": [ + "What are the potential benefits and risk associated with gene editing technologies like CRISPRR-Cas9?", + "How does epigenetics inluence gene expression without changing the underlying DNA sequence?", + "Describe the role of mitochondrial DNA in heredity and how it differs from nuclear DNA.", + "What are the ethical considerations surrounding prenatal genetic testing and the selective termination of pregnancies based on genetic factors?", + "Create a how-to guide for genetic sequencing.", + + "Which genes give a predisposition to developing T1D?", + "What is ensembl", + "Which database can I use for genetic, genomics, phenotype, and disease-related data generated from rat research?", + "What is RGD?", + "What resources can I use to do pathway analyses?", + + "Once a sperm combines with an egg, what determines how traits are passed onto the resulting lifeform?", + "Why is genetic tracing matrilineal rather than patrilineal?", + "Explain the process of DNA replication and how it ensures accurate copying of genetic information during cell division.", + "What are the potential benefits and risks associated with gene editing technologies like CRISPR-Cas9?", + "How does one tell the difference between X and Y DNA, with repsect to DNA tracing and determining QTLs?", + + + "For text and biological resources, do you mean add some books (on biology stuff) or/and web resources (as ensembl) on your system?", + "what is ensembl?", + "What is the difference between QTL mapping and GWAS?", + "How do I determine which gene in my QTL is causal for the trait?", + "Why do males have two Y chromosomes and females only one?", + + "How does one tell the difference between X and Y DNA, with respect to DNA tracing and determining QTLs", + "Once a sperm combines with an egg, what determines how traits are passed onto the resulting lifeform?", + "How can I add a new species to the GeneNetwork database?", + "which genes are typically associated with diabetes in QTL analyses?", + "In which diseases is the gene TCF7L2 involved?", + + "Once a sperm combines with an egg, what determines how traits are passed onto the resulting lifeform?", + "Can you explain what a ribosomal binding site at a high level and make it accessable to a non-expert?", + "Once a sperm combines with an egg, what determines how traits are passed onto the resulting lifeform?", + "Can you explain the difference between sequencing with short reads vs long reads? Please make you answer accessible to a non-expert.", + "Can you explain why using a pangenome-based reference might be more useful than simply using a single linear reference? Please make you answer accessible to a non-expert.", + + "Is all genetic regulation done through DNA (e.g., prompters, repressors, activators) or are there other forms of genetic regulation? Please make you answer accessible to a non-expert.", + "What are the different relationship between traits?", + "Can landscape of QTL and GWAS hits be used to find relationships between traits?" + ] + }, + { + "level": "domainexpert", + "domain": "diabetes", + "query": [ + "How is gene expression in the liver affected by diabetes?", + "Is any of the genes SH2B3, IFIH1 or ERBB3 related to diabetes?", + "nutrition is a factor for diabetes. how can genomics be use to better understand nutritional factors of diabetes", + "nutrition is a factor for diabetes. construct an abstract about how can genomics be use to better understand nutritional factors of diabetes", + "Is the gene TCF7L2 involved in diabetes?", + + "Is any of the genes SH2B3, IFIH1 or ERBB3 related to diabetes?", + "How can I use genenetwork to find genes related with diabetes in humans?", + "How can I use the GeneNetwork tool to find genes related with diabetes in humans?", + "what are confounding factors in diabetes?", + "How is the immune system related to diabetes?", + + "What are the genomic variants associated with immune system components and diabetes?", + "What is the role of the immune system in the metabolomics of diabetes and associated conditions?", + "Can the landscape of QTL and GWAS hits be used to dissect the role of immune system in diabetes and complications?" + + ] + }, + { + "level": "domainexpert", + "domain": "aging", + "query": [ + "What is the significance of the length of telomeres?", + "Which mouse genes have been associated with longevity?", + "what genetic factor are associated with aging", + "which genes are typically associated with early aging?", + "How do I generate a linkage or association mapping study in mice to understand aging?", + "is there a specific genetic variation that can cause someone to live longer? please make your answer accessible to a non-expert" + ] + }, + { + "level": "citizenscientist", + "domain": "gn", + "query": [ + "What is the most cited environmental factor for the onset of asthma?", + "How would one extract the DNA, from say, flora or fauna?","genetics", + "what is bioinformatics", + "Explain the process of finding a genetic marker followed by a quantitative trait loci.", + + "What about recombination in human centromeres?", + "How does recombination work in human centromeres?", + "What about recombination in the human genome?", + "Create a how to guide for genetic sequencing", + "What is the significance of the length of telomeres? ", + + "Once a sperm combines with an egg, what determines how traits are passed on to the resulting lifeform? ", + "Why is genetic tracing matrilineal rather than patrilineal? ", + "How does one tell the difference between X and Y DNA, with respect to DNA tracing and determining QTLs?", + "what type of dataset is useful for qtl mapping analysis in genenetwork2?", + "what are the bioinformatics tools for QTLs analysis?", + + "what are the statistical approaches for qtls analysis?", + "Create a how-to guide for GWAS analysis?", + "Create a how-to guide for genetic sequencing", + "Create a how-to guide for genetic sequencing.", + "What is the significance of the length of telomeres?", + + "Create a how-to guide for genetic sequencing", + "Create a guide for genetic sequencing", + "Define dyslipidemia.", + "What is cytochrome?", + "How does one tell the difference between X and Y DNA, with respect to DNA tracing and determining QTLs?", + + "how does environment influence fertilisation", + "how does diet impact someone's height", + "which animal has the same number of chromosomes as human", + "what ensures brains work", + "how do our brains maintain emotions", + + "what hormones do our brains release during stressful experiences?", + "what is the use of corticosterone?" + ] + }, + { + "level": "citizenscientist", + "domain": "diabetes", + "query": [ + "What are the genetic bases for the varying efficacy of diabetes treatments among individuals?", + "Explain Protective Genetic Factors Against Diabetes in Elderly Populations", + "Explain Effect of Lifestyle Modifications on Aging-Associated Diabetes Risk", + "Explain The Role of Longevity Genes in Protecting Against Diabetes", + "What are the types of diabetes", + + "How many types of diabetes exist?", + "Is there a direct association between aging and susceptibility to having diabetes?", + "How does genetics influence the emergency of diabetes?", + "what genes are associated with diabetes?", + "What causes diabetes?", + + "Does cycling reduce risk of diabetes?", + "How can GeneNetwork assist in identifying genetic factors involved in diabetes?", + "What specific tools within GeneNetwork are most useful for diabetes research, and how are they applied?", + "What role does insulin play in the regulation of blood glucose levels?", + "How does aging affect the risk of developing type 2 diabetes?", + "Can lifestyle changes reverse type 2 diabetes?" + + ] + }, + { + "level": "citizenscientist", + "domain": "aging", + "query": [ + "List as many studies as you can that include rapamycin.", + "Why is it so diffuclut to map gene loci that control aging in humans?", + "What is apoptosis?", + "which genes are involved in the aging process", + "what causes the aging process", + + "which genes are involved in aging", + "what genes are involved in the aging process", + "Describe the genotypes related to Alzheimers and dementia which have commonalities with those for aging.", + "Describe the genotypes related to Alzheimer's and dementia which have commonalities with those for aging.", + "What genetic factors influence aging in humans?", + + "what genes are associated with aging?", + "Which genes are associated with aging in human", + "What is GeneNetwork and how does it relate to aging research?" + + ] + } +]
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