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authorShelbySolomonDarnell2024-10-17 12:24:26 +0300
committerShelbySolomonDarnell2024-10-17 12:24:26 +0300
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tree270fd06daa18b2fc5687ee72d912cad771354bb0 /gnqa/paper2_eval/data/human-questions.json
parente0b2b0e55049b89805f73f291df1e28fa05487fe (diff)
downloadgn-ai-00cba4b9a1e88891f1f96a1199320092c1962343.tar.gz
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+[
+ {
+ "level": "domainexpert",
+ "domain": "gn",
+ "query": [
+ "What are the potential benefits and risk associated with gene editing technologies like CRISPRR-Cas9?",
+ "How does epigenetics inluence gene expression without changing the underlying DNA sequence?",
+ "Describe the role of mitochondrial DNA in heredity and how it differs from nuclear DNA.",
+ "What are the ethical considerations surrounding prenatal genetic testing and the selective termination of pregnancies based on genetic factors?",
+ "Create a how-to guide for genetic sequencing.",
+
+ "Which genes give a predisposition to developing T1D?",
+ "What is ensembl",
+ "Which database can I use for genetic, genomics, phenotype, and disease-related data generated from rat research?",
+ "What is RGD?",
+ "What resources can I use to do pathway analyses?",
+
+ "Once a sperm combines with an egg, what determines how traits are passed onto the resulting lifeform?",
+ "Why is genetic tracing matrilineal rather than patrilineal?",
+ "Explain the process of DNA replication and how it ensures accurate copying of genetic information during cell division.",
+ "What are the potential benefits and risks associated with gene editing technologies like CRISPR-Cas9?",
+ "How does one tell the difference between X and Y DNA, with repsect to DNA tracing and determining QTLs?",
+
+
+ "For text and biological resources, do you mean add some books (on biology stuff) or/and web resources (as ensembl) on your system?",
+ "what is ensembl?",
+ "What is the difference between QTL mapping and GWAS?",
+ "How do I determine which gene in my QTL is causal for the trait?",
+ "Why do males have two Y chromosomes and females only one?",
+
+ "How does one tell the difference between X and Y DNA, with respect to DNA tracing and determining QTLs",
+ "Once a sperm combines with an egg, what determines how traits are passed onto the resulting lifeform?",
+ "How can I add a new species to the GeneNetwork database?",
+ "which genes are typically associated with diabetes in QTL analyses?",
+ "In which diseases is the gene TCF7L2 involved?",
+
+ "Once a sperm combines with an egg, what determines how traits are passed onto the resulting lifeform?",
+ "Can you explain what a ribosomal binding site at a high level and make it accessable to a non-expert?",
+ "Once a sperm combines with an egg, what determines how traits are passed onto the resulting lifeform?",
+ "Can you explain the difference between sequencing with short reads vs long reads? Please make you answer accessible to a non-expert.",
+ "Can you explain why using a pangenome-based reference might be more useful than simply using a single linear reference? Please make you answer accessible to a non-expert.",
+
+ "Is all genetic regulation done through DNA (e.g., prompters, repressors, activators) or are there other forms of genetic regulation? Please make you answer accessible to a non-expert.",
+ "What are the different relationship between traits?",
+ "Can landscape of QTL and GWAS hits be used to find relationships between traits?"
+ ]
+ },
+ {
+ "level": "domainexpert",
+ "domain": "diabetes",
+ "query": [
+ "How is gene expression in the liver affected by diabetes?",
+ "Is any of the genes SH2B3, IFIH1 or ERBB3 related to diabetes?",
+ "nutrition is a factor for diabetes. how can genomics be use to better understand nutritional factors of diabetes",
+ "nutrition is a factor for diabetes. construct an abstract about how can genomics be use to better understand nutritional factors of diabetes",
+ "Is the gene TCF7L2 involved in diabetes?",
+
+ "Is any of the genes SH2B3, IFIH1 or ERBB3 related to diabetes?",
+ "How can I use genenetwork to find genes related with diabetes in humans?",
+ "How can I use the GeneNetwork tool to find genes related with diabetes in humans?",
+ "what are confounding factors in diabetes?",
+ "How is the immune system related to diabetes?",
+
+ "What are the genomic variants associated with immune system components and diabetes?",
+ "What is the role of the immune system in the metabolomics of diabetes and associated conditions?",
+ "Can the landscape of QTL and GWAS hits be used to dissect the role of immune system in diabetes and complications?"
+
+ ]
+ },
+ {
+ "level": "domainexpert",
+ "domain": "aging",
+ "query": [
+ "What is the significance of the length of telomeres?",
+ "Which mouse genes have been associated with longevity?",
+ "what genetic factor are associated with aging",
+ "which genes are typically associated with early aging?",
+ "How do I generate a linkage or association mapping study in mice to understand aging?",
+ "is there a specific genetic variation that can cause someone to live longer? please make your answer accessible to a non-expert"
+ ]
+ },
+ {
+ "level": "citizenscientist",
+ "domain": "gn",
+ "query": [
+ "What is the most cited environmental factor for the onset of asthma?",
+ "How would one extract the DNA, from say, flora or fauna?","genetics",
+ "what is bioinformatics",
+ "Explain the process of finding a genetic marker followed by a quantitative trait loci.",
+
+ "What about recombination in human centromeres?",
+ "How does recombination work in human centromeres?",
+ "What about recombination in the human genome?",
+ "Create a how to guide for genetic sequencing",
+ "What is the significance of the length of telomeres? ",
+
+ "Once a sperm combines with an egg, what determines how traits are passed on to the resulting lifeform? ",
+ "Why is genetic tracing matrilineal rather than patrilineal? ",
+ "How does one tell the difference between X and Y DNA, with respect to DNA tracing and determining QTLs?",
+ "what type of dataset is useful for qtl mapping analysis in genenetwork2?",
+ "what are the bioinformatics tools for QTLs analysis?",
+
+ "what are the statistical approaches for qtls analysis?",
+ "Create a how-to guide for GWAS analysis?",
+ "Create a how-to guide for genetic sequencing",
+ "Create a how-to guide for genetic sequencing.",
+ "What is the significance of the length of telomeres?",
+
+ "Create a how-to guide for genetic sequencing",
+ "Create a guide for genetic sequencing",
+ "Define dyslipidemia.",
+ "What is cytochrome?",
+ "How does one tell the difference between X and Y DNA, with respect to DNA tracing and determining QTLs?",
+
+ "how does environment influence fertilisation",
+ "how does diet impact someone's height",
+ "which animal has the same number of chromosomes as human",
+ "what ensures brains work",
+ "how do our brains maintain emotions",
+
+ "what hormones do our brains release during stressful experiences?",
+ "what is the use of corticosterone?"
+ ]
+ },
+ {
+ "level": "citizenscientist",
+ "domain": "diabetes",
+ "query": [
+ "What are the genetic bases for the varying efficacy of diabetes treatments among individuals?",
+ "Explain Protective Genetic Factors Against Diabetes in Elderly Populations",
+ "Explain Effect of Lifestyle Modifications on Aging-Associated Diabetes Risk",
+ "Explain The Role of Longevity Genes in Protecting Against Diabetes",
+ "What are the types of diabetes",
+
+ "How many types of diabetes exist?",
+ "Is there a direct association between aging and susceptibility to having diabetes?",
+ "How does genetics influence the emergency of diabetes?",
+ "what genes are associated with diabetes?",
+ "What causes diabetes?",
+
+ "Does cycling reduce risk of diabetes?",
+ "How can GeneNetwork assist in identifying genetic factors involved in diabetes?",
+ "What specific tools within GeneNetwork are most useful for diabetes research, and how are they applied?",
+ "What role does insulin play in the regulation of blood glucose levels?",
+ "How does aging affect the risk of developing type 2 diabetes?",
+ "Can lifestyle changes reverse type 2 diabetes?"
+
+ ]
+ },
+ {
+ "level": "citizenscientist",
+ "domain": "aging",
+ "query": [
+ "List as many studies as you can that include rapamycin.",
+ "Why is it so diffuclut to map gene loci that control aging in humans?",
+ "What is apoptosis?",
+ "which genes are involved in the aging process",
+ "what causes the aging process",
+
+ "which genes are involved in aging",
+ "what genes are involved in the aging process",
+ "Describe the genotypes related to Alzheimers and dementia which have commonalities with those for aging.",
+ "Describe the genotypes related to Alzheimer's and dementia which have commonalities with those for aging.",
+ "What genetic factors influence aging in humans?",
+
+ "what genes are associated with aging?",
+ "Which genes are associated with aging in human",
+ "What is GeneNetwork and how does it relate to aging research?"
+
+ ]
+ }
+] \ No newline at end of file