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-    "2015 - A Chromosome 13 locus is associated with male-specific mortality in mice.pdf",
-    "2021 - Footprints in the Sand Deep Taxonomic Comparisons in Vertebrate Genomics to Unveil the Genetic Programs of Human Longevity.pdf",
-    "2021 - Genetic loci and metabolic states associated with murine epigenetic aging.pdf",
-    "2021 -Mozhui- Epigenetic aging.pdf",
-    "2016 - Unraveling the message insights into comparative genomics.pdf",
-    "2012 - Chromatin Remodeling, DNA Damage Repair and Aging.pdf",
-    "2021 - Gene-by-environment modulation of lifespan and weight gain in the murine BXD family.pdf",
-    "2006 - THE GENETIC REGULATION OF THE RESPONSE OF HEMATOPOIETIC STEM_PROG.pdf",
-    "2012 - Genome-Scale Studies of Aging Challenges and Opportunities.pdf",
-    "2003 - Lifelong voluntary exercise in the mouse prevents.pdf"
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-    "11. Gelman R, Watson A, Bronson R et al (1988) Murine chromo- somal regions correlated with longevity. Genetics 118(4):693704 12. Jackson AU, Galecki AT, Burke DT et al (2002) Mouse loci associated with life span exhibit sex-specic and epistatic effects. J Gerontol A Biol Sci Med Sci 57(1):B9B15 13. Foreman JE, Lionikas A, Lang DH et al (2009) Genetic archi- tecture for hole-board behaviors across substantial time intervalsin young, middle-aged and old mice. Genes Brain Behav",
-    "Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. PLoS Genet. 14:e1007272. doi: 10.1371/journal.pgen.100 7272 Schchter, F., Faure-Delanef, L., Gunot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L., et al. (1994). Genetic associations with human longevity at the APOE and ACE loci. Nat. Genet. 6, 2932. doi: 10.1038/ng0194-29 Schinaman, J. M., Rana, A., Ja, W. W., Clark, R. I., and Walker, D. W. (2019).",
-    "of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin- like  growth factor I levels and increased life span. Endocrinology 144:37993810. DOI: https://doi.org/10.1210/en.  2003-0374, PMID: 12933651 de Haan G, Williams RW. 2005. A genetic and genomic approach to identify longevity genes in mice.  Mechanisms of Ageing and Development 126:133138. DOI: https://doi.org/10.1016/j.mad.2004.09.012,  PMID: 15610771",
-    "of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin- like  growth factor I levels and increased life span. Endocrinology 144:37993810. DOI: https://doi.org/10.1210/en.  2003-0374, PMID: 12933651 de Haan G, Williams RW. 2005. A genetic and genomic approach to identify longevity genes in mice.  Mechanisms of Ageing and Development 126:133138. DOI: https://doi.org/10.1016/j.mad.2004.09.012,  PMID: 15610771",
-    "Mulvey L, Sinclair A, Selman C (2014) Lifespan modulation in mice and the confounding effects of genetic background. J Genet Genomics 41:497503. doi: 10.1016/j.jgg.2014.06.002 OConnor TP, Lee A, Jarvis JUM, Buffenstein R (2002) Prolonged longevity in naked mole-rats: age-related changes in metabolism, body composition and gastrointestinal function. Comp Biochem Physiol A 133:835842. doi: 10.1016/S1095-6433(02)00198-8 Opazo JC, Palma RE, Melo F, Lessa EP (2005) Adaptive evolution of",
-    "/ mice by Lmna heterozy- gosity ameliorates progeroid phenotypes and extends  lifespan [143, 174, 175].",
-    "References 1. Hook Met al.Genetic cartography of longevity in humans and mice: Current landscape and horizons.  Biochim. Biophys. Acta1864, 27182732 (2018). 2. Kuningas Met al.Genes encoding longevity: from model organisms to humans. Aging Cell7, 270 280 (2008). [PubMed: 18208581]  3. de Magalhes JP, Wuttke D, Wood SH, Plank M & V ora C Genome-environment interactions that  modulate aging: Powerful targets for drug discovery. Pharmacol. Rev. 64, 88101 (2012). [PubMed:  22090473]",
-    "\"Murine chromosomal regions correlated with longevity.\" Genetics 118: 693-704.",
-    "expression of alpha-1,2-mannosidase I extends lifespan in  Drosophila melanogaster and Caenorhabditis elegans . Aging Cell,  2009 , 8(4), 370-9.  [73] Wang, H.D.; Kazemi-Esfarjani, P.; Benzer, S. Multiple-stress  analysis for isolation of Drosophila longevity genes . Proc Natl  Acad Sci U S A , 2004 , 101(34), 12610-5.  [74] Lin, Y.J.; Seroude, L.; Benzer, S. Extended life-span and stress  resistance in the Drosophila mutant methuselah . Science , 1998 ,  282(5390), 943-6.",
-    "sion analysis of mouse liver genes: effect of age and of thelongevity mutant Prop1df. J Gerontol A Biol Sci Med Sci 56: B72B80, 2001. 12.Fabrizio P, Pozza F, Pletcher SD, Gendron CM, and Longo VD. Regulation of longevity and stress resistance by Sch9 in Yeast. Science 292: 288 290, 2001. 13.Haase D, Lehmann MH, Korner MM, Korfer R, Sigusch HH, and Figulla HR. Identi cation and validation of selective"
-  ],
-  "answer": "The mouse genes associated with longevity include:  1. **Mouse loci associated with life span**: These loci exhibit sex-specific and epistatic effects [1]. 2. **Mouse growth hormone receptor**: Alterations in this gene result in increased lifespan [3], [4]. 3. **Lmna heterozygosity**: This genetic modification ameliorates progeroid phenotypes and extends lifespan [6].  These references provide evidence of specific genes and loci in mice that have been linked to increased longevity.",
-  "question": "Which mouse genes have been associated with longevity?"
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-    "2015 - A Chromosome 13 locus is associated with male-specific mortality in mice.pdf",
-    "2021 - Footprints in the Sand Deep Taxonomic Comparisons in Vertebrate Genomics to Unveil the Genetic Programs of Human Longevity.pdf",
-    "2021 - Genetic loci and metabolic states associated with murine epigenetic aging.pdf",
-    "2021 -Mozhui- Epigenetic aging.pdf",
-    "2016 - Unraveling the message insights into comparative genomics.pdf",
-    "2012 - Chromatin Remodeling, DNA Damage Repair and Aging.pdf",
-    "2021 - Gene-by-environment modulation of lifespan and weight gain in the murine BXD family.pdf",
-    "2006 - THE GENETIC REGULATION OF THE RESPONSE OF HEMATOPOIETIC STEM_PROG.pdf",
-    "2012 - Genome-Scale Studies of Aging Challenges and Opportunities.pdf",
-    "2003 - Lifelong voluntary exercise in the mouse prevents.pdf"
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-    "Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. PLoS Genet. 14:e1007272. doi: 10.1371/journal.pgen.100 7272 Schchter, F., Faure-Delanef, L., Gunot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L., et al. (1994). Genetic associations with human longevity at the APOE and ACE loci. Nat. Genet. 6, 2932. doi: 10.1038/ng0194-29 Schinaman, J. M., Rana, A., Ja, W. W., Clark, R. I., and Walker, D. W. (2019).",
-    "of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin- like  growth factor I levels and increased life span. Endocrinology 144:37993810. DOI: https://doi.org/10.1210/en.  2003-0374, PMID: 12933651 de Haan G, Williams RW. 2005. A genetic and genomic approach to identify longevity genes in mice.  Mechanisms of Ageing and Development 126:133138. DOI: https://doi.org/10.1016/j.mad.2004.09.012,  PMID: 15610771",
-    "of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin- like  growth factor I levels and increased life span. Endocrinology 144:37993810. DOI: https://doi.org/10.1210/en.  2003-0374, PMID: 12933651 de Haan G, Williams RW. 2005. A genetic and genomic approach to identify longevity genes in mice.  Mechanisms of Ageing and Development 126:133138. DOI: https://doi.org/10.1016/j.mad.2004.09.012,  PMID: 15610771",
-    "Mulvey L, Sinclair A, Selman C (2014) Lifespan modulation in mice and the confounding effects of genetic background. J Genet Genomics 41:497503. doi: 10.1016/j.jgg.2014.06.002 OConnor TP, Lee A, Jarvis JUM, Buffenstein R (2002) Prolonged longevity in naked mole-rats: age-related changes in metabolism, body composition and gastrointestinal function. Comp Biochem Physiol A 133:835842. doi: 10.1016/S1095-6433(02)00198-8 Opazo JC, Palma RE, Melo F, Lessa EP (2005) Adaptive evolution of",
-    "/ mice by Lmna heterozy- gosity ameliorates progeroid phenotypes and extends  lifespan [143, 174, 175].",
-    "References 1. Hook Met al.Genetic cartography of longevity in humans and mice: Current landscape and horizons.  Biochim. Biophys. Acta1864, 27182732 (2018). 2. Kuningas Met al.Genes encoding longevity: from model organisms to humans. Aging Cell7, 270 280 (2008). [PubMed: 18208581]  3. de Magalhes JP, Wuttke D, Wood SH, Plank M & V ora C Genome-environment interactions that  modulate aging: Powerful targets for drug discovery. Pharmacol. Rev. 64, 88101 (2012). [PubMed:  22090473]",
-    "\"Murine chromosomal regions correlated with longevity.\" Genetics 118: 693-704.",
-    "expression of alpha-1,2-mannosidase I extends lifespan in  Drosophila melanogaster and Caenorhabditis elegans . Aging Cell,  2009 , 8(4), 370-9.  [73] Wang, H.D.; Kazemi-Esfarjani, P.; Benzer, S. Multiple-stress  analysis for isolation of Drosophila longevity genes . Proc Natl  Acad Sci U S A , 2004 , 101(34), 12610-5.  [74] Lin, Y.J.; Seroude, L.; Benzer, S. Extended life-span and stress  resistance in the Drosophila mutant methuselah . Science , 1998 ,  282(5390), 943-6.",
-    "sion analysis of mouse liver genes: effect of age and of thelongevity mutant Prop1df. J Gerontol A Biol Sci Med Sci 56: B72B80, 2001. 12.Fabrizio P, Pozza F, Pletcher SD, Gendron CM, and Longo VD. Regulation of longevity and stress resistance by Sch9 in Yeast. Science 292: 288 290, 2001. 13.Haase D, Lehmann MH, Korner MM, Korfer R, Sigusch HH, and Figulla HR. Identi cation and validation of selective"
-  ],
-  "answer": "The mouse genes associated with longevity include:  1. **Mouse loci associated with life span**: These loci exhibit sex-specific and epistatic effects [1]. 2. **Mouse growth hormone receptor**: Alterations in this gene result in increased lifespan [3], [4]. 3. **Lmna heterozygosity**: This genetic modification ameliorates progeroid phenotypes and extends lifespan [6].  These references provide evidence of specific genes and loci in mice that have been linked to increased longevity.",
-  "question": "Which mouse genes have been associated with longevity?"
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-    "2015 - A Chromosome 13 locus is associated with male-specific mortality in mice.pdf",
-    "2021 - Footprints in the Sand Deep Taxonomic Comparisons in Vertebrate Genomics to Unveil the Genetic Programs of Human Longevity.pdf",
-    "2021 - Genetic loci and metabolic states associated with murine epigenetic aging.pdf",
-    "2021 -Mozhui- Epigenetic aging.pdf",
-    "2016 - Unraveling the message insights into comparative genomics.pdf",
-    "2012 - Chromatin Remodeling, DNA Damage Repair and Aging.pdf",
-    "2021 - Gene-by-environment modulation of lifespan and weight gain in the murine BXD family.pdf",
-    "2006 - THE GENETIC REGULATION OF THE RESPONSE OF HEMATOPOIETIC STEM_PROG.pdf",
-    "2012 - Genome-Scale Studies of Aging Challenges and Opportunities.pdf",
-    "2003 - Lifelong voluntary exercise in the mouse prevents.pdf"
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-    "Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. PLoS Genet. 14:e1007272. doi: 10.1371/journal.pgen.100 7272 Schchter, F., Faure-Delanef, L., Gunot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L., et al. (1994). Genetic associations with human longevity at the APOE and ACE loci. Nat. Genet. 6, 2932. doi: 10.1038/ng0194-29 Schinaman, J. M., Rana, A., Ja, W. W., Clark, R. I., and Walker, D. W. (2019).",
-    "of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin- like  growth factor I levels and increased life span. Endocrinology 144:37993810. DOI: https://doi.org/10.1210/en.  2003-0374, PMID: 12933651 de Haan G, Williams RW. 2005. A genetic and genomic approach to identify longevity genes in mice.  Mechanisms of Ageing and Development 126:133138. DOI: https://doi.org/10.1016/j.mad.2004.09.012,  PMID: 15610771",
-    "of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin- like  growth factor I levels and increased life span. Endocrinology 144:37993810. DOI: https://doi.org/10.1210/en.  2003-0374, PMID: 12933651 de Haan G, Williams RW. 2005. A genetic and genomic approach to identify longevity genes in mice.  Mechanisms of Ageing and Development 126:133138. DOI: https://doi.org/10.1016/j.mad.2004.09.012,  PMID: 15610771",
-    "Mulvey L, Sinclair A, Selman C (2014) Lifespan modulation in mice and the confounding effects of genetic background. J Genet Genomics 41:497503. doi: 10.1016/j.jgg.2014.06.002 OConnor TP, Lee A, Jarvis JUM, Buffenstein R (2002) Prolonged longevity in naked mole-rats: age-related changes in metabolism, body composition and gastrointestinal function. Comp Biochem Physiol A 133:835842. doi: 10.1016/S1095-6433(02)00198-8 Opazo JC, Palma RE, Melo F, Lessa EP (2005) Adaptive evolution of",
-    "/ mice by Lmna heterozy- gosity ameliorates progeroid phenotypes and extends  lifespan [143, 174, 175].",
-    "References 1. Hook Met al.Genetic cartography of longevity in humans and mice: Current landscape and horizons.  Biochim. Biophys. Acta1864, 27182732 (2018). 2. Kuningas Met al.Genes encoding longevity: from model organisms to humans. Aging Cell7, 270 280 (2008). [PubMed: 18208581]  3. de Magalhes JP, Wuttke D, Wood SH, Plank M & V ora C Genome-environment interactions that  modulate aging: Powerful targets for drug discovery. Pharmacol. Rev. 64, 88101 (2012). [PubMed:  22090473]",
-    "\"Murine chromosomal regions correlated with longevity.\" Genetics 118: 693-704.",
-    "expression of alpha-1,2-mannosidase I extends lifespan in  Drosophila melanogaster and Caenorhabditis elegans . Aging Cell,  2009 , 8(4), 370-9.  [73] Wang, H.D.; Kazemi-Esfarjani, P.; Benzer, S. Multiple-stress  analysis for isolation of Drosophila longevity genes . Proc Natl  Acad Sci U S A , 2004 , 101(34), 12610-5.  [74] Lin, Y.J.; Seroude, L.; Benzer, S. Extended life-span and stress  resistance in the Drosophila mutant methuselah . Science , 1998 ,  282(5390), 943-6.",
-    "sion analysis of mouse liver genes: effect of age and of thelongevity mutant Prop1df. J Gerontol A Biol Sci Med Sci 56: B72B80, 2001. 12.Fabrizio P, Pozza F, Pletcher SD, Gendron CM, and Longo VD. Regulation of longevity and stress resistance by Sch9 in Yeast. Science 292: 288 290, 2001. 13.Haase D, Lehmann MH, Korner MM, Korfer R, Sigusch HH, and Figulla HR. Identi cation and validation of selective"
-  ],
-  "answer": "The mouse genes associated with longevity include:  1. **Mouse loci associated with life span**: These loci exhibit sex-specific and epistatic effects [1]. 2. **Mouse growth hormone receptor**: Alterations in this gene result in increased lifespan [3], [4]. 3. **Lmna heterozygosity**: This genetic modification ameliorates progeroid phenotypes and extends lifespan [6].  These references provide evidence of specific genes and loci in mice that have been linked to increased longevity.",
-  "question": "Which mouse genes have been associated with longevity?"
-}
\ No newline at end of file