1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
|
"""Module contains tests for gn3.computations.qtlreaper"""
from unittest import TestCase
import pytest
from gn3.computations.qtlreaper import (
parse_reaper_main_results,
organise_reaper_main_results,
parse_reaper_permutation_results)
from tests.unit.sample_test_data import organised_trait_1
class TestQTLReaper(TestCase):
"""Class for testing qtlreaper interface functions."""
@pytest.mark.unit_test
def test_parse_reaper_main_results(self):
"""Test that the main results file is parsed correctly."""
self.assertEqual(
parse_reaper_main_results(
"tests/unit/computations/data/qtlreaper/main_output_sample.txt"),
[
{
"ID": "T1", "Locus": "rs31443144", "Chr": 1, "cM": 1.500,
"Mb": 3.010, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "T1", "Locus": "rs6269442", "Chr": 1, "cM": 1.500,
"Mb": 3.492, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "T1", "Locus": "rs32285189", "Chr": 1, "cM": 1.630,
"Mb": 3.511, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "T1", "Locus": "rs258367496", "Chr": 1, "cM": 1.630,
"Mb": 3.660, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "T1", "Locus": "rs32430919", "Chr": 1, "cM": 1.750,
"Mb": 3.777, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "T1", "Locus": "rs36251697", "Chr": 1, "cM": 1.880,
"Mb": 3.812, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "T1", "Locus": "rs30658298", "Chr": 1, "cM": 2.010,
"Mb": 4.431, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "T1", "Locus": "rs51852623", "Chr": 1, "cM": 2.010,
"Mb": 4.447, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "T1", "Locus": "rs31879829", "Chr": 1, "cM": 2.140,
"Mb": 4.519, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "T1", "Locus": "rs36742481", "Chr": 1, "cM": 2.140,
"Mb": 4.776, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
}
])
@pytest.mark.unit_test
def test_parse_reaper_permutation_results(self):
"""Test that the permutations results file is parsed correctly."""
self.assertEqual(
parse_reaper_permutation_results(
"tests/unit/computations/data/qtlreaper/permu_output_sample.txt"),
[4.44174, 5.03825, 5.08167, 5.18119, 5.18578, 5.24563, 5.24619,
5.24619, 5.27961, 5.28228, 5.43903, 5.50188, 5.51694, 5.56830,
5.63874, 5.71346, 5.71936, 5.74275, 5.76764, 5.79815, 5.81671,
5.82775, 5.89659, 5.92117, 5.93396, 5.93396, 5.94957])
@pytest.mark.unit_test
def test_organise_reaper_main_results(self):
"""Check that results are organised correctly."""
self.assertEqual(
organise_reaper_main_results([
{
"ID": "1", "Locus": "rs31443144", "Chr": 1, "cM": 1.500,
"Mb": 3.010, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "1", "Locus": "rs6269442", "Chr": 1, "cM": 1.500,
"Mb": 3.492, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "1", "Locus": "rs32285189", "Chr": 1, "cM": 1.630,
"Mb": 3.511, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "1", "Locus": "rs258367496", "Chr": 1, "cM": 1.630,
"Mb": 3.660, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "1", "Locus": "rs32430919", "Chr": 1, "cM": 1.750,
"Mb": 3.777, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "1", "Locus": "rs36251697", "Chr": 1, "cM": 1.880,
"Mb": 3.812, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "1", "Locus": "rs30658298", "Chr": 1, "cM": 2.010,
"Mb": 4.431, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "1", "Locus": "rs51852623", "Chr": 2, "cM": 2.010,
"Mb": 4.447, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "1", "Locus": "rs31879829", "Chr": 2, "cM": 2.140,
"Mb": 4.519, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
},
{
"ID": "1", "Locus": "rs36742481", "Chr": 2, "cM": 2.140,
"Mb": 4.776, "LRS": 0.500, "Additive": -0.074,
"pValue": 1.000
}
]),
organised_trait_1)
|
