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-rw-r--r--gn3/db/species.py31
-rw-r--r--gn3/partial_correlations.py38
2 files changed, 68 insertions, 1 deletions
diff --git a/gn3/db/species.py b/gn3/db/species.py
index 0deae4e..1e5015f 100644
--- a/gn3/db/species.py
+++ b/gn3/db/species.py
@@ -30,3 +30,34 @@ def get_chromosome(name: str, is_species: bool, conn: Any) -> Optional[Tuple]:
with conn.cursor() as cursor:
cursor.execute(_sql)
return cursor.fetchall()
+
+def translate_to_mouse_gene_id(species: str, geneid: int, conn: Any) -> int:
+ """
+ Translate rat or human geneid to mouse geneid
+
+ This is a migration of the
+ `web.webqtl.correlation/CorrelationPage.translateToMouseGeneID` function in
+ GN1
+ """
+ assert species in ("rat", "mouse", "human"), "Invalid species"
+ if geneid is None:
+ return 0
+
+ if species == "mouse":
+ return geneid
+
+ with conn.cursor as cursor:
+ if species == "rat":
+ cursor.execute(
+ "SELECT mouse FROM GeneIDXRef WHERE rat = %s", geneid)
+ rat_geneid = cursor.fetchone()
+ if rat_geneid:
+ return rat_geneid[0]
+
+ cursor.execute(
+ "SELECT mouse FROM GeneIDXRef WHERE human = %s", geneid)
+ human_geneid = cursor.fetchone()
+ if human_geneid:
+ return human_geneid[0]
+
+ return 0 # default if all else fails
diff --git a/gn3/partial_correlations.py b/gn3/partial_correlations.py
index c556d10..1fb0ccc 100644
--- a/gn3/partial_correlations.py
+++ b/gn3/partial_correlations.py
@@ -6,7 +6,7 @@ GeneNetwork1.
"""
from functools import reduce
-from typing import Any, Sequence
+from typing import Any, Tuple, Sequence
def control_samples(controls: Sequence[dict], sampleslist: Sequence[str]):
"""
@@ -86,3 +86,39 @@ def fix_samples(primary_trait: dict, control_traits: Sequence[dict]) -> Sequence
control_vals_vars[0],
tuple(primary_trait[sample]["variance"] for sample in primary_samples),
control_vals_vars[1])
+
+def find_identical_traits(
+ primary_name: str, primary_value: float, control_names: Tuple[str, ...],
+ control_values: Tuple[float, ...]) -> Tuple[str, ...]:
+ """
+ Find traits that have the same value when the values are considered to
+ 3 decimal places.
+
+ This is a migration of the
+ `web.webqtl.correlation.correlationFunction.findIdenticalTraits` function in
+ GN1.
+ """
+ def __merge_identicals__(
+ acc: Tuple[str, ...],
+ ident: Tuple[str, Tuple[str, ...]]) -> Tuple[str, ...]:
+ return acc + ident[1]
+
+ def __dictify_controls__(acc, control_item):
+ ckey = "{:.3f}".format(control_item[0])
+ return {**acc, ckey: acc.get(ckey, tuple()) + (control_item[1],)}
+
+ return (reduce(## for identical control traits
+ __merge_identicals__,
+ (item for item in reduce(# type: ignore[var-annotated]
+ __dictify_controls__, zip(control_values, control_names),
+ {}).items() if len(item[1]) > 1),
+ tuple())
+ or
+ reduce(## If no identical control traits, try primary and controls
+ __merge_identicals__,
+ (item for item in reduce(# type: ignore[var-annotated]
+ __dictify_controls__,
+ zip((primary_value,) + control_values,
+ (primary_name,) + control_names), {}).items()
+ if len(item[1]) > 1),
+ tuple()))