path: root/wqflask/wqflask/static/new/javascript/lod_chart.coffee

lodchart = () ->
    width = 800
    height = 500
    margin = {left:60, top:40, right:40, bottom: 40, inner:5}
    axispos = {xtitle:25, ytitle:30, xlabel:5, ylabel:5}
    titlepos = 20
    manhattanPlot = false
    additive = false
    ylim = null
    additive_ylim = null
    nyticks = 5
    yticks = null
    additive_yticks = null
    chrGap = 8
    darkrect = "#F1F1F9"
    lightrect = "#FBFBFF" 
    lodlinecolor = "darkslateblue"
    additivelinecolor = "red"
    linewidth = 2
    suggestivecolor = "gainsboro"
    significantcolor = "#EBC7C7"
    pointcolor = "#E9CFEC" # pink
    pointsize = 0 # default = no visible points at markers
    pointstroke = "black"
    title = ""
    xlab = "Chromosome"
    ylab = "LRS score"
    additive_ylab = "Additive Effect"
    rotate_ylab = null
    yscale = d3.scale.linear()
    additive_yscale = d3.scale.linear()
    xscale = null
    pad4heatmap = false
    lodcurve = null
    lodvarname = null
    markerSelect = null
    chrSelect = null
    pointsAtMarkers = true
    
  
    ## the main function
    chart = (selection) ->
      selection.each (data) ->
        
        #console.log("data:", data)
        
        if manhattanPlot == true
            pointcolor = "darkslateblue"
            pointsize = 2
        
        lodvarname = lodvarname ? data.lodnames[0]
        data[lodvarname] = (Math.abs(x) for x in data[lodvarname]) # take absolute values
        ylim = ylim ? [0, d3.max(data[lodvarname])]    
        if additive
            data['additive'] = (Math.abs(x) for x in data['additive'])
            additive_ylim = additive_ylim ? [0, d3.max(data['additive'])]   

        lodvarnum = data.lodnames.indexOf(lodvarname)

        # Select the svg element, if it exists.
        svg = d3.select(this).selectAll("svg").data([data])

        # Otherwise, create the skeletal chart.
        gEnter = svg.enter().append("svg").append("g")

        # Update the outer dimensions.
        svg.attr("width", width+margin.left+margin.right)
           .attr("height", height+margin.top+margin.bottom)

        # Update the inner dimensions.
        g = svg.select("g")

        # box
        g.append("rect")
         .attr("x", margin.left)
         .attr("y", margin.top)
         .attr("height", height)
         .attr("width", width)
         .attr("fill", darkrect)
         .attr("stroke", "none")

        yscale.domain(ylim)
              .range([height+margin.top, margin.top+margin.inner])

        # if yticks not provided, use nyticks to choose pretty ones
        yticks = yticks ? yscale.ticks(nyticks)

        #if data['additive'].length > 0
        if additive
            additive_yscale.domain(additive_ylim)
                  .range([height+margin.top, margin.top+margin.inner + height/2])
                  
            additive_yticks = additive_yticks ? additive_yscale.ticks(nyticks)
  
        # reorganize lod,pos by chromosomes
        reorgLodData(data, lodvarname)
  
        # add chromosome scales (for x-axis)
        data = chrscales(data, width, chrGap, margin.left, pad4heatmap)
        xscale = data.xscale
  
        # chr rectangles
        chrSelect =
                  g.append("g").attr("class", "chrRect")
                   .selectAll("empty")
                   .data(data.chrnames)
                   .enter()
                   .append("rect")
                   .attr("id", (d) -> "chrrect#{d[0]}")
                   .attr("x", (d,i) ->
                     return data.chrStart[i] if i==0 and pad4heatmap
                     data.chrStart[i]-chrGap/2)
                   .attr("width", (d,i) ->
                      return data.chrEnd[i] - data.chrStart[i]+chrGap/2 if (i==0 or i+1 == data.chrnames.length) and pad4heatmap
                      data.chrEnd[i] - data.chrStart[i]+chrGap)
                   .attr("y", margin.top)
                   .attr("height", height)
                   .attr("fill", (d,i) ->
                      return darkrect if i % 2

                      lightrect)
                   .attr("stroke", "none")
                   .on("click", (d) ->
                      console.log("d is:", d)
                      redraw_plot(d)
                      BD.putData({chr: d[0], length: d[1]});
                      BD.showButton()
                    )   
  
        # x-axis labels
        xaxis = g.append("g").attr("class", "x axis")
        xaxis.selectAll("empty")
             .data(data.chrnames)
             .enter()
             .append("text")
             .text((d) -> d[0])
             .attr("x", (d,i) -> (data.chrStart[i]+data.chrEnd[i])/2)
             .attr("y", margin.top+height+axispos.xlabel)
             .attr("dominant-baseline", "hanging")
             .attr("text-anchor", "middle")
             .attr("cursor", "pointer")
             .on("click", (d) ->
                 redraw_plot(d)
              )   
             
        xaxis.append("text").attr("class", "title")
             .attr("y", margin.top+height+axispos.xtitle)
             .attr("x", margin.left+width/2)
             .attr("fill", "slateblue")
             .text(xlab)

  
        redraw_plot = (chr_ob) ->
             #console.log("chr_name is:", chr_ob[0])
             #console.log("chr_length is:", chr_ob[1])
             $('#topchart').remove()
             $('#chart_container').append('<div class="qtlcharts" id="topchart"></div>')
             chr_plot = new Chr_Lod_Chart(600, 1200, chr_ob, manhattanPlot)
  
        # y-axis
        rotate_ylab = rotate_ylab ? (ylab.length > 1)
        yaxis = g.append("g").attr("class", "y axis")
        yaxis.selectAll("empty")
             .data(yticks)
             .enter()
             .append("line")
             .attr("y1", (d) -> yscale(d))
             .attr("y2", (d) -> yscale(d))
             .attr("x1", margin.left)
             .attr("x2", margin.left+7)
             .attr("fill", "none")
             .attr("stroke", "white")
             .attr("stroke-width", 1)
             .style("pointer-events", "none")
             
        yaxis.selectAll("empty")
             .data(yticks)
             .enter()
             .append("text")
             .attr("y", (d) -> yscale(d))
             .attr("x", margin.left-axispos.ylabel)
             .attr("fill", "blue")
             .attr("dominant-baseline", "middle")
             .attr("text-anchor", "end")
             .text((d) -> formatAxis(yticks)(d))
             
        yaxis.append("text").attr("class", "title")
             .attr("y", margin.top+height/2)
             .attr("x", margin.left-axispos.ytitle)
             .text(ylab)
             .attr("transform", if rotate_ylab then "rotate(270,#{margin.left-axispos.ytitle},#{margin.top+height/2})" else "")
             .attr("text-anchor", "middle")
             .attr("fill", "slateblue")
  
        #if data['additive'].length > 0
        if additive
            rotate_additive_ylab = rotate_additive_ylab ? (additive_ylab.length > 1)
            additive_yaxis = g.append("g").attr("class", "y axis")
            additive_yaxis.selectAll("empty")
                 .data(additive_yticks)
                 .enter()
                 .append("line")
                 .attr("y1", (d) -> additive_yscale(d))
                 .attr("y2", (d) -> additive_yscale(d))
                 .attr("x1", margin.left + width)
                 .attr("x2", margin.left + width - 7)
                 .attr("fill", "none")
                 .attr("stroke", "white")
                 .attr("stroke-width", 1)
                 .style("pointer-events", "none")
        
            additive_yaxis.selectAll("empty")
                 .data(additive_yticks)
                 .enter()
                 .append("text")
                 .attr("y", (d) -> additive_yscale(d))
                 .attr("x", (d) -> margin.left + width + axispos.ylabel + 20)
                 .attr("fill", "green")
                 .attr("dominant-baseline", "middle")
                 .attr("text-anchor", "end")
                 .text((d) -> formatAxis(additive_yticks)(d))
                 
            additive_yaxis.append("text").attr("class", "title")
                 .attr("y", margin.top+1.5*height)
                 .attr("x", margin.left + width + axispos.ytitle)
                 .text(additive_ylab)
                 .attr("transform", if rotate_additive_ylab then "rotate(270,#{margin.left + width + axispos.ytitle}, #{margin.top+height*1.5})" else "")
                 .attr("text-anchor", "middle")
                 .attr("fill", "green")
  
        if 'suggestive' of data
            suggestive_bar = g.append("g").attr("class", "suggestive")
            suggestive_bar.selectAll("empty")
                 .data([data.suggestive])
                 .enter()
                 .append("line")
                 .attr("y1", (d) -> yscale(d))
                 .attr("y2", (d) -> yscale(d))
                 .attr("x1", margin.left)
                 .attr("x2", margin.left+width)
                 .attr("fill", "none")
                 .attr("stroke", suggestivecolor)
                 .attr("stroke-width", 5)
                 .style("pointer-events", "none")
    
            suggestive_bar = g.append("g").attr("class", "significant")
            suggestive_bar.selectAll("empty")
                 .data([data.significant])
                 .enter()
                 .append("line")
                 .attr("y1", (d) -> yscale(d))
                 .attr("y2", (d) -> yscale(d))
                 .attr("x1", margin.left)
                 .attr("x2", margin.left+width)
                 .attr("fill", "none")
                 .attr("stroke", significantcolor)
                 .attr("stroke-width", 5)
                 .style("pointer-events", "none")
                 
        if manhattanPlot == false
            # lod curves by chr
            lodcurve = (chr, lodcolumn) ->
                d3.svg.line()
                  .x((d) -> xscale[chr](d))
                  .y((d,i) -> yscale(data.lodByChr[chr][i][lodcolumn]))
                  
            if additive
                additivecurve = (chr, lodcolumn) ->
                    d3.svg.line()
                      .x((d) -> xscale[chr](d))
                      .y((d,i) -> additive_yscale(data.additiveByChr[chr][i][lodcolumn]))
      
            curves = g.append("g").attr("id", "curves")
      
            for chr in data.chrnames
              if chr.indexOf(data['chr'])
                  curves.append("path")
                        .datum(data.posByChr[chr[0]])
                        .attr("d", lodcurve(chr[0], lodvarnum))
                        .attr("stroke", lodlinecolor)
                        .attr("fill", "none")
                        .attr("stroke-width", linewidth)
                        .style("pointer-events", "none")
            
            if additive
                for chr in data.chrnames
                    if chr.indexOf(data['chr'])
                        curves.append("path")
                              .datum(data.posByChr[chr[0]])
                              .attr("d", additivecurve(chr[0], lodvarnum))
                              .attr("stroke", additivelinecolor)
                              .attr("fill", "none")
                              .attr("stroke-width", 1)
                              .style("pointer-events", "none")
        
        # points at markers
        console.log("before pointsize")
        if pointsize > 0
            console.log("pointsize > 0 !!!")
          markerpoints = g.append("g").attr("id", "markerpoints_visible")
          markerpoints.selectAll("empty")
                      .data(data.markers)
                      .enter()
                      .append("circle")
                      .attr("cx", (d) -> xscale[d.chr](d.pos))
                      .attr("cy", (d) -> yscale(d.lod))
                      .attr("r", pointsize)
                      .attr("fill", pointcolor)
                      .attr("stroke", pointstroke)
                      .attr("pointer-events", "hidden")
  
        # title
        titlegrp = g.append("g").attr("class", "title")
         .append("text")
         .attr("x", margin.left+width/2)
         .attr("y", margin.top-titlepos)
         .text(title)
  
        # another box around edge
        g.append("rect")
         .attr("x", margin.left)
         .attr("y", margin.top)
         .attr("height", height)
         .attr("width", () ->
            return(data.chrEnd[-1..][0]-margin.left) if pad4heatmap
            data.chrEnd[-1..][0]-margin.left+chrGap/2)
         .attr("fill", "none")
         .attr("stroke", "black")
         .attr("stroke-width", "none")
  
        if pointsAtMarkers
          # these hidden points are what gets selected...a bit larger
          hiddenpoints = g.append("g").attr("id", "markerpoints_hidden")
  
          markertip = d3.tip()
                        .attr('class', 'd3-tip')
                        .html((d) ->
                          [d.name, " LRS = #{d3.format('.2f')(d.lod)}"])
                        .direction("e")
                        .offset([0,10])
          svg.call(markertip)
  
          markerSelect =
            hiddenpoints.selectAll("empty")
                        .data(data.markers)
                        .enter()
                        .append("circle")
                        .attr("cx", (d) -> xscale[d.chr](d.pos))
                        .attr("cy", (d) -> yscale(d.lod))
                        .attr("id", (d) -> d.name)
                        .attr("r", d3.max([pointsize*2, 3]))
                        .attr("opacity", 0)
                        .attr("fill", pointcolor)
                        .attr("stroke", pointstroke)
                        .attr("stroke-width", "1")
                        .on "mouseover.paneltip", (d) ->
                           d3.select(this).attr("opacity", 1)
                           markertip.show(d)
                        .on "mouseout.paneltip", ->
                           d3.select(this).attr("opacity", 0)
                                          .call(markertip.hide)
  
    ## configuration parameters
    chart.width = (value) ->
      return width unless arguments.length
      width = value
      chart
  
    chart.height = (value) ->
      return height unless arguments.length
      height = value
      chart
  
    chart.margin = (value) ->
      return margin unless arguments.length
      margin = value
      chart
  
    chart.titlepos = (value) ->
      return titlepos unless arguments.length
      titlepos
      chart
  
    chart.axispos = (value) ->
      return axispos unless arguments.length
      axispos = value
      chart
      
    chart.manhattanPlot = (value) ->
      return manhattanPlot unless arguments.length
      manhattanPlot = value
      chart
  
    chart.ylim = (value) ->
      return ylim unless arguments.length
      ylim = value
      chart
      
    #if data['additive'].length > 0
    chart.additive_ylim = (value) ->
      return additive_ylim unless arguments.length
      additive_ylim = value
      chart
      
    chart.nyticks = (value) ->
      return nyticks unless arguments.length
      nyticks = value
      chart
  
    chart.yticks = (value) ->
      return yticks unless arguments.length
      yticks = value
      chart
  
    chart.chrGap = (value) ->
      return chrGap unless arguments.length
      chrGap = value
      chart
  
    chart.darkrect = (value) ->
      return darkrect unless arguments.length
      darkrect = value
      chart
  
    chart.lightrect = (value) ->
      return lightrect unless arguments.length
      lightrect = value
      chart
  
    chart.linecolor = (value) ->
      return linecolor unless arguments.length
      linecolor = value
      chart
  
    chart.linewidth = (value) ->
      return linewidth unless arguments.length
      linewidth = value
      chart
  
    chart.pointcolor = (value) ->
      return pointcolor unless arguments.length
      pointcolor = value
      chart
  
    chart.pointsize = (value) ->
      return pointsize unless arguments.length
      pointsize = value
      chart
  
    chart.pointstroke = (value) ->
      return pointstroke unless arguments.length
      pointstroke = value
      chart
  
    chart.title = (value) ->
      return title unless arguments.length
      title = value
      chart
  
    chart.xlab = (value) ->
      return xlab unless arguments.length
      xlab = value
      chart
  
    chart.ylab = (value) ->
      return ylab unless arguments.length
      ylab = value
      chart
  
    chart.rotate_ylab = (value) ->
      return rotate_ylab if !arguments.length
      rotate_ylab = value
      chart
  
    chart.lodvarname = (value) ->
      return lodvarname unless arguments.length
      lodvarname = value
      chart
  
    chart.pad4heatmap = (value) ->
      return pad4heatmap unless arguments.length
      pad4heatmap = value
      chart
  
    chart.pointsAtMarkers = (value) ->
      return pointsAtMarkers unless arguments.length
      pointsAtMarkers = value
      chart
  
    chart.yscale = () ->
      return yscale
    
    chart.additive = () ->
      return additive
    
    #if data['additive'].length > 0
    chart.additive_yscale = () ->
      return additive_yscale
  
    chart.xscale = () ->
      return xscale
  
    if manhattanPlot == false
        chart.lodcurve = () ->
          return lodcurve
    
    #if data['additive'].length > 0
    chart.additivecurve = () ->
      return additivecurve
  
    chart.markerSelect = () ->
      return markerSelect
  
    chart.chrSelect = () ->
      return chrSelect
  
    # return the chart function
    chart