1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
|
<html>
<head>
<meta http-equiv=Content-Type content="text/html; charset=macintosh">
<meta name=ProgId content=PowerPoint.Slide>
<meta name=Generator content="Microsoft Macintosh PowerPoint 10">
<link id=Main-File rel=Main-File href="WebQTLDemo.htm">
<title>PowerPoint Presentation - Complex trait analysis, develop-ment, and
genomics</title>
<link title="Presentation File" type="application/powerpoint" rel=alternate
href=WebQTLDemo.ppt>
<script>
if ( ! top.PPTPRESENTATION ) {
window.location.replace( "endshow.htm" );
}
</script>
<meta name=Description
content="Jun-19-03: WebQTL link to www.webqtl.org/search.html">
<link rel=Stylesheet href="master03_stylesheet.css">
<style media=print>
<!--.sld
{left:0px !important;
width:6.0in !important;
height:4.5in !important;
font-size:76% !important;}
-->
</style>
<script language=JavaScript src=script.js></script><script language=JavaScript><!--
gId="slide0026.htm"
if ( !parent.base.g_done && (parent.base.msie < 0 ) ) {
parent.base.g_done = 1;
document.location.replace( parent.base.GetHrefObj(parent.base.g_currentSlide).m_slideHref);
}
if( !IsNts() ) Redirect( "PPTSld", gId );
var g_hasTrans = true, g_autoTrans = false, g_transSecs = 1;
//-->
</script><script for=window event=onload language=JavaScript><!--
if( !IsSldOrNts() ) return;
if( MakeNotesVis() ) return;
LoadSld( gId );
playList();MakeSldVis(1);
//-->
</script>
</head>
<body style='margin:0px;background-color:black' onclick="DocumentOnClick(event)"
onresize="_RSW()" onkeypress="_KPH(event)">
<div id=SlideObj class=sld style='position:absolute;top:0px;left:0px;
width:755px;height:566px;font-size:16px;background-color:#484848;clip:rect(0%, 101%, 101%, 0%);
visibility:hidden'><img src="master03_background.gif" v:shapes="_x0000_s1026"
style='position:absolute;top:0%;left:0%;width:100.0%;height:100.0%'>
<div style='position:absolute;top:3.0%;left:2.11%;width:96.42%;height:19.61%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'>
<div class=T style='mso-line-spacing:" 0 ";mso-margin-left-alt:232;
mso-text-indent-alt:0;position:absolute;top:0%;left:.96%;width:97.39%;
height:100.0%'><span style='position:absolute;top:0%;left:0%;width:100.0%'><span
style='font-size:68%'><i>WebQTL<span style="mso-spacerun:
yes"> </span><br>
</i></span></span><span style='position:
absolute;top:32.43%;left:4.37%;width:95.76%'><span style='font-size:68%'><i>link
to <br>
</i></span></span><span style='position:absolute;top:58.55%;left:4.37%;
width:95.76%'><span style='font-size:86%'><i>www.webqtl.org/search.html</i></span><span
style='font-size:68%;mso-special-format:lastCR;display:none'><i><br>
</i></span></span></div>
</div>
<div style='position:absolute;top:36.57%;left:2.51%;width:73.24%;height:45.05%;
filter:DropShadow(Color=#000000, OffX=1, OffY=1)'>
<div class=B style='position:absolute;top:0%;left:2.71%;width:97.28%;
height:81.96%'>
<div style='mso-line-spacing:" 0 ";mso-margin-left-alt:348;mso-text-indent-alt:
56;position:absolute;top:0%;left:0%;width:94.6%;height:31.57%'><span
style='position:absolute;top:0%;left:7.46%;width:92.53%'><span
style='font-size:94%;color:#E9EB5D;mso-color-index:3'><span style='mso-special-format:
"numbullet3\,1";color:#FBFDB8;position:absolute;left:-8.06%;font-family:Times;
font-size:99%'>1.</span></span><span style='font-size:94%;color:#E9EB5D;
mso-color-index:3'>Discovering shared expression </span></span><span
style='position:absolute;top:43.93%;left:7.46%;width:82.12%'><span
style='font-size:94%;color:#E9EB5D;mso-color-index:3'>patterns<br>
</span></span></div>
<div style='mso-line-spacing:" 0 ";mso-margin-left-alt:348;mso-text-indent-alt:
56;position:absolute;top:41.14%;left:0%;width:84.94%;height:31.57%'><span
style='position:absolute;top:0%;left:8.31%;width:91.46%'><span
style='font-size:94%;color:#E9EB5D;mso-color-index:3'><span style='mso-special-format:
"numbullet3\,2";color:#FBFDB8;position:absolute;left:-9.09%;font-family:Times;
font-size:99%'>2.</span></span><span style='font-size:94%;color:#E9EB5D;
mso-color-index:3'>Discovering upstream </span></span><span style='position:
absolute;top:43.93%;left:8.31%;width:91.46%'><span style='font-size:94%;
color:#E9EB5D;mso-color-index:3'>modulators (QTLs)<br>
</span></span></div>
<div style='mso-line-spacing:" 0 ";mso-margin-left-alt:348;mso-text-indent-alt:
56;position:absolute;top:82.29%;left:0%;width:100.0%;height:17.7%'><span
style='position:absolute;top:0%;left:7.06%;width:92.75%'><span
style='font-size:94%;color:#E9EB5D;mso-color-index:3'><span style='mso-special-format:
"numbullet3\,3";color:#FBFDB8;position:absolute;left:-7.61%;font-family:Times;
font-size:99%'>3.</span></span><span style='font-size:94%;color:#E9EB5D;
mso-color-index:3'>Discovering downstream targets</span></span></div>
</div>
</div>
<div style='position:absolute;top:82.15%;left:4.1%;width:96.42%;height:18.55%;
filter:DropShadow(Color=#000000, OffX=2, OffY=2)'></div>
<img border=0 src="slide0026_image107.gif" style='position:absolute;top:65.9%;
left:65.29%;width:26.35%;height:10.77%'></div>
<div id=NotesObj style='display:none'>
<table style='color:white' border=0 width="100%">
<tr>
<td width=5 nowrap></td>
<td width="100%"></td>
</tr>
<tr>
<td colspan=1></td>
<td align=left colspan=1><font face=Helvetica size=3>Part 3.<span
style="mso-spacerun: yes"> </span>Many investigators would like to
discover the set of downstream targets of a gene of interest.</font><br>
</td>
</tr>
<tr>
<td colspan=1></td>
<td align=left colspan=1><br>
</td>
</tr>
<tr>
<td colspan=1></td>
<td align=left colspan=1><font face=Helvetica size=3>In a genetic and
functional sense, that question can only be addressed effectively if there is
genetic variation in the particular gene.<span style="mso-spacerun:
yes"> </span>We know that Fos is an important transcription factor, but
unless it is polymorphic between C57BL/6J and DBA/2J, then it cannot generate
a genetic variance signal with which we can work. We can still study
covariance of Fos and hundreds of other transcripts (an interesting
exercise), but there are no genetic causes-and-effects.</font><br>
</td>
</tr>
</table>
</div>
<script language=JavaScript><!--
function playList() {
}
//-->
</script>
</body>
</html>
|
