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Rat HXB/BXH Published Phenotypes Database
<A HREF="/webqtl/main.py?FormID=editHtml"><img src="/images/modify.gif" alt="modify this page" border= 0 valign="middle"></A></P>
<P class="subtitle"> Summary:</P>
<Blockquote><P>
This HXB/BXH Phenotypes Database includes phenotype scores and values for HXB and BXH strains assembled by Michal <A HREF="http://www.hhmi.org/research/scholars/prav.html" target="_blank" class="fs14">Pravenec</A> and Vladimir Kren, primarily from published sources. The HXB/BXH strains have been used for more than 15 years in cardiovascular and metabolic research and in the study of skeletal structure. These recombinant inbred strains are derived from a cross between the spontaneously hypertensive rat (SHR/Ola or HSR = H) and Brown Norway (BN-Lx/Cub or BN = B). For background on the HXB strain set please Pravenec and colleagues (<A HREF="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2708818" target="_blank" class="fs14">1989</A>, <A HREF="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15119932" target="_blank" class="fs14">2004</A>) and <A HREF="http://pharmacology.ucsd.edu/Research_Faculty/mpprintz2000.asp" target="_blank" class="fs14">Printz</A> and colleagues (<A HREF="http://jap.physiology.org/cgi/content/full/94/6/2510" target="_blank" class="fs14">2003</A>).</P>
<P>The database currently includes approximately 85 traits. You can generate a complete list of these traits by searching with a single asterisk (*) as your search term.</P>
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<Blockquote><P>
The HXB/BXH Genotype Database was assembled by Robert W. Williams and Michal Pravenec using a compendium of approximately 1100 markers that have been typed over the past decade. This WebQTL BXH/HXB map assembly has been rigorously error-checked and has a cumulative genetic length of roughly 1350 cM (adjusted for the 4X expansion of RI strains) for all autosomes. No double-recombinant genotypes were tolerated in this file and all unspecified genotypes were imputed from neighboring markers. These HXB/BXH chromosomal maps therefore differ in many details from several other consensus maps built using the same set of markers.</P>
</Blockquote>
<P class="subtitle"> Acknowledgments:</P>
<Blockquote><P>The initial construction of this database was by Michal Pravenec with assistance of Robert W. Williams. For additional details please contact Dr. Michal Pravenec, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic. Phone: +(420)241062297; E-mail: pravenec@biomed.cas.cz
</P></Blockquote>
<P class="subtitle"> Information about this text file:</P>
<Blockquote><P>This text file originally generated by RWW, Dec 3, 2004. Updated by RWW, Dec 3, 2004; MP and RWW, Dec 17, 2004.
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