diff options
Diffstat (limited to 'web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0025.htm')
| -rwxr-xr-x | web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0025.htm | 104 |
1 files changed, 104 insertions, 0 deletions
diff --git a/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0025.htm b/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0025.htm new file mode 100755 index 00000000..e9ce598f --- /dev/null +++ b/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0025.htm @@ -0,0 +1,104 @@ +<html>
<head>
<meta name=ProgId content=PowerPoint.Slide>
<meta name=Generator content="Microsoft Macintosh PowerPoint 11">
<title>PowerPoint Presentation - Complex trait analysis, develop-ment, and
genomics</title>
<link title="Presentation File" type="application/powerpoint" rel=alternate
href="webqtl_demo2.ppt.ppt">
<script> +if ( ! top.PPTPRESENTATION ) { + window.location.replace( "endshow.htm" ); +} +</script>
<meta name=Description
content="Aug-15-05: Evaluating Ctbp2 using other resources">
<style media=print>
<!--.sld
{left:0px !important;
width:6.0in !important;
height:4.5in !important;
font-size:76% !important;}
-->
</style>
<script language=Javascript src=script.js></script> +<script language=JavaScript> +function font_size() { + var min = window.innerWidth/20; + if ( min > window.innerHeight/20 ) + min = window.innerHeight/20; + + return min+"pt"; +} +var SoundEnabled = navigator.plugins && navigator.plugins["LiveAudio"]; +function restore() { + self.location.reload(); +} +function set_size() { + document.SlideLayer.width = window.innerWidth; + document.SlideLayer.height = window.innerHeight; +} +document.captureEvents(Event.MOUSEDOWN); +document.captureEvents(Event.KEYPRESS); +document.onkeypress = _KPH ; +document.onmousedown = _KPH ; + parent.base.highlite(); +</script><script language=JavaScript><!--
+function DoOnLoad() { + LoadNavSld("slide0025.htm"); +}//-->
+</script>
</head>
<body onresize="restore()" onload="DoOnLoad()" style='font-size:&{font_size()};'
bgcolor="#000000">
<script> + +g_origHeight = 566; +g_origWidth = 755; +g_width = window.innerWidth - 10; +g_height = window.innerHeight - 10; + +g_top = 0; +g_left = 0; + +if ( g_width < ( g_origWidth * g_height /g_origHeight ) ) + g_height = g_width * g_origHeight / g_origWidth; +else + g_width = g_origWidth * g_height / g_origHeight; + +g_top = (window.innerHeight - g_height) / 2; +g_left = (window.innerWidth - g_width) / 2; + +document.write( '<layer id=SlideLayer BGCOLOR=#484848 background="" top=' + g_top + ' left=' + g_left + ' height=' + g_height + ' width=' + g_width + ' >' ); +document.SlideLayer.clip.top = 0; +document.SlideLayer.clip.left = 0; +document.SlideLayer.clip.height = g_height; +document.SlideLayer.clip.width = g_width; +function new_font_size() { + var size = 11 * g_width / g_origWidth; + if ( size < 1 ) size = 1; + return size+"pt"; +} +</script>
<div id=SlideObj class=sld style='position:relative;font-size:&{new_font_size()};'><script> + mytop = 0 * g_height; myleft = 0 * g_width; myheight = 1 * g_height; mywidth = 1 * g_width; + document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); +</script>
<div><script language=JavaScript><!--
+ht = g_height; +wd = g_width; +document.write( +'<img src="master03_background.png" height=' + ht + ' width=' + wd + '>' ); +//-->
+</script></div>
</layer><script> + mytop = 0 * g_height; myleft = 0.01 * g_width; myheight = 0.08 * g_height; mywidth = 1.01 * g_width; + document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); +</script>
<div><script> + mytop = 0.01 * g_height; myleft = 0 * g_width; myheight = 0.06 * g_height; mywidth = 0.98 * g_width; + document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); +</script>
<div style='text-align:left;font-family:"Gill Sans";font-weight:normal;
font-style:normal;text-decoration:none;text-shadow:none;text-effect:none;
mso-fareast-hint:no;layout-flow:horizontal;color:#E9EB5D;font-size:293%;
mso-text-raise:0%;mso-line-spacing:"-358 0 -1";mso-margin-left-alt:233;
mso-text-indent-alt:0;mso-line-spacing:"-358 0 -1";mso-margin-left-alt:233;
mso-text-indent-alt:0'><span style='font-family:Verdana;font-size:64%'>Evaluating
</span><span style='font-family:Verdana;font-size:64%'><i>Ctbp2</i></span><span
style='font-family:Verdana;font-size:64%'> using other resources</span><span
style='font-family:Verdana;font-size:73%;mso-special-format:lastCR;display:
none'><i><br>
</i></span></div>
</layer></div>
</layer><script> + mytop = 0.1 * g_height; myleft = 0.01 * g_width; myheight = 0.53 * g_height; mywidth = 0.48 * g_width; + document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); +</script>
<div><script language=JavaScript><!--
+xx = 0.01 * g_width; +yy = 0.1 * g_height; +ht = 0.53 * g_height; +wd = 0.48 * g_width; +document.write( +'<img border=0 src="slide0011_image087.png" x=' + xx + ' y=' +yy + ' height=' + ht + ' width=' + wd + '>' ); +//-->
+</script></div>
</layer><script> + mytop = 0.4 * g_height; myleft = 0.19 * g_width; myheight = 0.54 * g_height; mywidth = 0.78 * g_width; + document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); +</script>
<div><script language=JavaScript><!--
+xx = 0.19 * g_width; +yy = 0.4 * g_height; +ht = 0.54 * g_height; +wd = 0.78 * g_width; +document.write( +'<img border=0 src="slide0011_image088.png" x=' + xx + ' y=' +yy + ' height=' + ht + ' width=' + wd + '>' ); +//-->
+</script></div>
</layer></div>
</LAYER>
+
<layer>
<div id=NotesObj style='display:none'>
<table style='color:white' border=0 width="100%">
<tr>
<td width=5 nowrap></td>
<td width="100%"></td>
</tr>
<tr>
<td colspan=1></td>
<td align=left colspan=1><font face=Verdana size=3>Ctbp2 should also be
considered a high priority biological candidate gene responsible for
modulating App expression levels. The C-terminal binding protein 2 is a
transcriptional co-repressor also known as Ribeye.</font><font
face=Times-Roman size=3> The gene produces two transcripts encoding distinct
proteins. The short form is a transcriptional repressor that binds a
Pro-X-Asp-Leu-Ser peptide motif and interacts with several transcription
factors including EVI1, ZFPM1, and ZFHX1A (aka TCF8, deltaEF1). The longer
isoform is a major component of specialized synapses in photoreceptors. Both
proteins contain a NAD+ binding domain similar to NAD+-dependent
2-hydroxyacid dehydrogenases.</font><br>
</td>
</tr>
<tr>
<td colspan=1></td>
<td align=left colspan=1><br>
</td>
</tr>
<tr>
<td colspan=1></td>
<td align=left colspan=1><font face=Verdana size=3>Notes:</font><br>
</td>
</tr>
<tr>
<td colspan=1></td>
<td align=left colspan=1><font face=Verdana size=3>1. To find out more about
CTBP2 protein and the Ctbp2 gene, link to iHOP at
http://www.pdg.cnb.uam.es/UniPub/iHOP/ and type in CTBP2</font><br>
</td>
</tr>
<tr>
<td colspan=1></td>
<td align=left colspan=1><font face=Verdana size=3>Try Arrowsmith at
http://arrowsmith.psych.uic.edu/cgi-test/arrowsmith_uic/pubsmith.cgi</font><br>
</td>
</tr>
<tr>
<td colspan=1></td>
<td align=left colspan=1><font face=Verdana size=3>2. Both APP and CTBP2 are
involved in oxidoreducatase activity or Notch signaling. To establish this
common gene ontology visit NCBI<span style="mso-spacerun: yes">
</span>http://www.ncbi.nih.gov/entrez/query.fcgi?db=gene and enter each gene
symbol.</font><br>
</td>
</tr>
<tr>
<td colspan=1></td>
<td align=left colspan=1><font face=Verdana size=3>3. You can get
interesting hints regarding Ctbp2 expression partners by examining the
genetic correlations between Ctbp2 probe set 1422887_a_at and all other
transcripts on the M430 Affymetrix array. Use the Striatum data set because
we already know from previous work (the previous slide) that this gene is a
cis QTL.<span style="mso-spacerun: yes"> </span>You should be able to
show that Ctbp2 and Notch3 have antagonistic expression patterns in
striatum. The negative genetic correlation with E2f4 is even stronger. The
transcript also has a high positive genetic correlation with Rdh14. Of
particular interest with respect to APP protein processing, Ctbp2 covaries
positively with Bace2 (the transcript of the beta site APP-cleaving enzyme
2).</font><br>
</td>
</tr>
<tr>
<td colspan=1></td>
<td align=left colspan=1><br>
</td>
</tr>
<tr>
<td colspan=1></td>
<td align=left colspan=1><br>
</td>
</tr>
</table>
</div>
</layer>
<script language=JavaScript><!--
+//-->
+</script><script language=JavaScript><!--
+function playList() { + +} +//-->
+</script>
</body>
</html>
\ No newline at end of file |