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diff --git a/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0025.htm b/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0025.htm deleted file mode 100755 index e9ce598f..00000000 --- a/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0025.htm +++ /dev/null @@ -1,104 +0,0 @@ -<html> <head> <meta name=ProgId content=PowerPoint.Slide> <meta name=Generator content="Microsoft Macintosh PowerPoint 11"> <title>PowerPoint Presentation - Complex trait analysis, develop-ment, and genomics</title> <link title="Presentation File" type="application/powerpoint" rel=alternate href="webqtl_demo2.ppt.ppt"> <script> -if ( ! top.PPTPRESENTATION ) { - window.location.replace( "endshow.htm" ); -} -</script> <meta name=Description content="Aug-15-05: Evaluating Ctbp2 using other resources"> <style media=print> <!--.sld {left:0px !important; width:6.0in !important; height:4.5in !important; font-size:76% !important;} --> </style> <script language=Javascript src=script.js></script> -<script language=JavaScript> -function font_size() { - var min = window.innerWidth/20; - if ( min > window.innerHeight/20 ) - min = window.innerHeight/20; - - return min+"pt"; -} -var SoundEnabled = navigator.plugins && navigator.plugins["LiveAudio"]; -function restore() { - self.location.reload(); -} -function set_size() { - document.SlideLayer.width = window.innerWidth; - document.SlideLayer.height = window.innerHeight; -} -document.captureEvents(Event.MOUSEDOWN); -document.captureEvents(Event.KEYPRESS); -document.onkeypress = _KPH ; -document.onmousedown = _KPH ; - parent.base.highlite(); -</script><script language=JavaScript><!-- -function DoOnLoad() { - LoadNavSld("slide0025.htm"); -}//--> -</script> </head> <body onresize="restore()" onload="DoOnLoad()" style='font-size:&{font_size()};' bgcolor="#000000"> <script> - -g_origHeight = 566; -g_origWidth = 755; -g_width = window.innerWidth - 10; -g_height = window.innerHeight - 10; - -g_top = 0; -g_left = 0; - -if ( g_width < ( g_origWidth * g_height /g_origHeight ) ) - g_height = g_width * g_origHeight / g_origWidth; -else - g_width = g_origWidth * g_height / g_origHeight; - -g_top = (window.innerHeight - g_height) / 2; -g_left = (window.innerWidth - g_width) / 2; - -document.write( '<layer id=SlideLayer BGCOLOR=#484848 background="" top=' + g_top + ' left=' + g_left + ' height=' + g_height + ' width=' + g_width + ' >' ); -document.SlideLayer.clip.top = 0; -document.SlideLayer.clip.left = 0; -document.SlideLayer.clip.height = g_height; -document.SlideLayer.clip.width = g_width; -function new_font_size() { - var size = 11 * g_width / g_origWidth; - if ( size < 1 ) size = 1; - return size+"pt"; -} -</script> <div id=SlideObj class=sld style='position:relative;font-size:&{new_font_size()};'><script> - mytop = 0 * g_height; myleft = 0 * g_width; myheight = 1 * g_height; mywidth = 1 * g_width; - document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); -</script> <div><script language=JavaScript><!-- -ht = g_height; -wd = g_width; -document.write( -'<img src="master03_background.png" height=' + ht + ' width=' + wd + '>' ); -//--> -</script></div> </layer><script> - mytop = 0 * g_height; myleft = 0.01 * g_width; myheight = 0.08 * g_height; mywidth = 1.01 * g_width; - document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); -</script> <div><script> - mytop = 0.01 * g_height; myleft = 0 * g_width; myheight = 0.06 * g_height; mywidth = 0.98 * g_width; - document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); -</script> <div style='text-align:left;font-family:"Gill Sans";font-weight:normal; font-style:normal;text-decoration:none;text-shadow:none;text-effect:none; mso-fareast-hint:no;layout-flow:horizontal;color:#E9EB5D;font-size:293%; mso-text-raise:0%;mso-line-spacing:"-358 0 -1";mso-margin-left-alt:233; mso-text-indent-alt:0;mso-line-spacing:"-358 0 -1";mso-margin-left-alt:233; mso-text-indent-alt:0'><span style='font-family:Verdana;font-size:64%'>Evaluating </span><span style='font-family:Verdana;font-size:64%'><i>Ctbp2</i></span><span style='font-family:Verdana;font-size:64%'> using other resources</span><span style='font-family:Verdana;font-size:73%;mso-special-format:lastCR;display: none'><i><br> </i></span></div> </layer></div> </layer><script> - mytop = 0.1 * g_height; myleft = 0.01 * g_width; myheight = 0.53 * g_height; mywidth = 0.48 * g_width; - document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); -</script> <div><script language=JavaScript><!-- -xx = 0.01 * g_width; -yy = 0.1 * g_height; -ht = 0.53 * g_height; -wd = 0.48 * g_width; -document.write( -'<img border=0 src="slide0011_image087.png" x=' + xx + ' y=' +yy + ' height=' + ht + ' width=' + wd + '>' ); -//--> -</script></div> </layer><script> - mytop = 0.4 * g_height; myleft = 0.19 * g_width; myheight = 0.54 * g_height; mywidth = 0.78 * g_width; - document.write( '<layer top=' + mytop + ' left=' + myleft + ' height=' + myheight + ' width=' + mywidth + ' >' ); -</script> <div><script language=JavaScript><!-- -xx = 0.19 * g_width; -yy = 0.4 * g_height; -ht = 0.54 * g_height; -wd = 0.78 * g_width; -document.write( -'<img border=0 src="slide0011_image088.png" x=' + xx + ' y=' +yy + ' height=' + ht + ' width=' + wd + '>' ); -//--> -</script></div> </layer></div> </LAYER> - <layer> <div id=NotesObj style='display:none'> <table style='color:white' border=0 width="100%"> <tr> <td width=5 nowrap></td> <td width="100%"></td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Verdana size=3>Ctbp2 should also be considered a high priority biological candidate gene responsible for modulating App expression levels. The C-terminal binding protein 2 is a transcriptional co-repressor also known as Ribeye.</font><font face=Times-Roman size=3> The gene produces two transcripts encoding distinct proteins. The short form is a transcriptional repressor that binds a Pro-X-Asp-Leu-Ser peptide motif and interacts with several transcription factors including EVI1, ZFPM1, and ZFHX1A (aka TCF8, deltaEF1). The longer isoform is a major component of specialized synapses in photoreceptors. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases.</font><br> </td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><br> </td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Verdana size=3>Notes:</font><br> </td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Verdana size=3>1. To find out more about CTBP2 protein and the Ctbp2 gene, link to iHOP at http://www.pdg.cnb.uam.es/UniPub/iHOP/ and type in CTBP2</font><br> </td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Verdana size=3>Try Arrowsmith at http://arrowsmith.psych.uic.edu/cgi-test/arrowsmith_uic/pubsmith.cgi</font><br> </td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Verdana size=3>2. Both APP and CTBP2 are involved in oxidoreducatase activity or Notch signaling. To establish this common gene ontology visit NCBI<span style="mso-spacerun: yes"> </span>http://www.ncbi.nih.gov/entrez/query.fcgi?db=gene and enter each gene symbol.</font><br> </td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><font face=Verdana size=3>3. You can get interesting hints regarding Ctbp2 expression partners by examining the genetic correlations between Ctbp2 probe set 1422887_a_at and all other transcripts on the M430 Affymetrix array. Use the Striatum data set because we already know from previous work (the previous slide) that this gene is a cis QTL.<span style="mso-spacerun: yes"> </span>You should be able to show that Ctbp2 and Notch3 have antagonistic expression patterns in striatum. The negative genetic correlation with E2f4 is even stronger. The transcript also has a high positive genetic correlation with Rdh14. Of particular interest with respect to APP protein processing, Ctbp2 covaries positively with Bace2 (the transcript of the beta site APP-cleaving enzyme 2).</font><br> </td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><br> </td> </tr> <tr> <td colspan=1></td> <td align=left colspan=1><br> </td> </tr> </table> </div> </layer> <script language=JavaScript><!-- -//--> -</script><script language=JavaScript><!-- -function playList() { - -} -//--> -</script> </body> </html> \ No newline at end of file |