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| author | zsloan | 2015-03-27 20:28:51 +0000 |
|---|---|---|
| committer | zsloan | 2015-03-27 20:28:51 +0000 |
| commit | d0911a04958a04042da02a334ccc528dae79cc17 (patch) | |
| tree | 3c48e2e937c1dbeaf00a5697c87ed251afa5c8f1 /web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0059.htm | |
| parent | a840ad18e1fe3db98a359a159e9b9b72367a2839 (diff) | |
| download | genenetwork2-d0911a04958a04042da02a334ccc528dae79cc17.tar.gz | |
Removed everything from 'web' directory except genofiles and renamed the directory to 'genotype_files'
Diffstat (limited to 'web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0059.htm')
| -rwxr-xr-x | web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0059.htm | 104 |
1 files changed, 0 insertions, 104 deletions
diff --git a/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0059.htm b/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0059.htm deleted file mode 100755 index 5ba9ff5c..00000000 --- a/web/tutorial/ppt/html/webqtl_demo2.ppt_files/slide0059.htm +++ /dev/null @@ -1,104 +0,0 @@ -<html>
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mso-text-indent-alt:0'><span style='font-family:Verdana;font-size:64%'>Evaluating
</span><span style='font-family:Verdana;font-size:64%'><i>Ctbp2</i></span><span
style='font-family:Verdana;font-size:64%'> using other resources</span><span
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none'><i><br>
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<td align=left colspan=1><font face=Verdana size=3>Ctbp2 should also be
considered a high priority biological candidate gene responsible for
modulating App expression levels. The<span style="mso-spacerun: yes">
</span>C-terminal binding protein 2 is a transcriptional co-repressor also
known as Ribeye.</font><font face=Times-Roman size=3> The gene produces two
transcripts encoding distinct proteins. The short form is a transcriptional
repressor that binds a Pro-X-Asp-Leu-Ser peptide motif common to adenoviral
oncoprotein E1a and a related motif in BKLF. This short form also interacts<span
style="mso-spacerun: yes"> </span>with several transcription factors
including EVI1, ZFPM1, and<span style="mso-spacerun: yes">
</span>ZFHX1A (aka TCF8, deltaEF1). The longer isoform is a major component
of specialized synapses in photoreceptors. Both proteins contain a NAD+
binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases.</font><br>
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<td align=left colspan=1><font face=Verdana size=3>Notes:</font><br>
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<td align=left colspan=1><font face=Verdana size=3>1. To find out more about
CTBP2 protein and the Ctbp2 gene, link to iHOP at
http://www.pdg.cnb.uam.es/UniPub/iHOP/ and type in CTBP2</font><br>
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<td align=left colspan=1><font face=Verdana size=3>Try Arrowsmith at
http://arrowsmith.psych.uic.edu/cgi-test/arrowsmith_uic/pubsmith.cgi</font><br>
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<td align=left colspan=1><font face=Verdana size=3>2. Both APP and CTBP2 are
involved in oxidoreducatase activity or Notch signalling. To estabilish this
common gene ontology visit NCBI<span style="mso-spacerun: yes">
</span>http://www.ncbi.nih.gov/entrez/query.fcgi?db=gene<span
style="mso-spacerun: yes"> </span>and enter each gene symbol.</font><br>
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<td align=left colspan=1><font face=Verdana size=3>3. You can get intersting
hints regarding Ctbp2 expression partners by examining the genetic
correlations between Ctbp2 probe set 1422887_a_at and all other transcripts
on the M430 Affymetrix array. Use the Striatum data set because we already
know from previous work (the previous slide) that this gene is a cis
QTL.<span style="mso-spacerun: yes"> </span>You should be able to show
that Ctbp2 and Notch3 have antagonistic expression patterns in striatum. The
negative genetic correlation with E2f4 is even stronger. The transcript also
has a high positive genetic correlation with Rdh14. Of particualr interest
with respect to APP protein processing, Ctbp2 covaries positiviely with
Bace2 (the transcript of the beta site APP-cleaving enzyme 2).</font><br>
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