Removed everything from 'web' directory except genofiles and renamed the directory to 'genotype_files'

author: zsloan 2015-03-27 20:28:51 +0000
committer: zsloan 2015-03-27 20:28:51 +0000
commit: d0911a04958a04042da02a334ccc528dae79cc17 (patch)
tree: 3c48e2e937c1dbeaf00a5697c87ed251afa5c8f1 /web/tutorial/ppt/WebQTLDemo_files/slide0059.htm
parent: a840ad18e1fe3db98a359a159e9b9b72367a2839 (diff)
download: genenetwork2-d0911a04958a04042da02a334ccc528dae79cc17.tar.gz
1 files changed, 0 insertions, 128 deletions
diff --git a/web/tutorial/ppt/WebQTLDemo_files/slide0059.htm b/web/tutorial/ppt/WebQTLDemo_files/slide0059.htm
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<title>PowerPoint Presentation  -  Complex trait analysis, develop-ment, and
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<div><span style='font-family:"Gill Sans";font-size:267%;color:#E9EB5D'><i>App
and many other<br>
</i></span></div>
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   <td align=left colspan=1><font face=Verdana size=3>Genes must be polymorphic
   to generate downstream genetic effects (as opposed to downstream molecular
   effects). Hars2 meets this condition because we have already mapped a
   functional polymorphism in the gene. We can therefore posit that Hars2 is a
   QT gene. What transcripts are downstream? <i>App</i> is one obvious
   candidate, but there are many more.</font><br>
   </td>
  </tr>
  <tr>
   <td colspan=1></td>
   <td align=left colspan=1><br>
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   <td align=left colspan=1><font face=Verdana size=3>The are several ways to
   look for downstream targets. The best and most obvious is to look up all
   transcripts that have high correlations with Hars2 itself. You should know
   how to do this. An alternative method is shown here for teaching purpose and
   to show you what to do if your gene of interest is not in our database. You
   need to know:</font><br>
   </td>
  </tr>
  <tr>
   <td colspan=1></td>
   <td align=left colspan=1><br>
   </td>
  </tr>
  <tr>
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   <td align=left colspan=1><font face=Times size=3>1.</font><font
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   to find a surrogate marker; a marker that is located very close to your gene
   of interest.</font><br>
   </td>
  </tr>
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   <td align=left colspan=1><font face=Verdana size=3>2. That your gene is
   polymorphic between C57BL/6J and DBA/2J.</font><br>
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  </tr>
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   <td colspan=1></td>
   <td align=left colspan=1><br>
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  <tr>
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   <td align=left colspan=1><font face=Verdana size=3>LetÕs look at the
   correlation of Hars2 with BXD genotypes as shown in the slide above to
   illustrate how to use markers as surrogate traits.</font><br>
   </td>
  </tr>
  <tr>
   <td colspan=1></td>
   <td align=left colspan=1><font face=Verdana size=3>Go to the Trait Date and
   Editing window one more time. We want the data for Hars2 this time, not App.
   You should be able to show that Hars2 has a high<span style="mso-spacerun:
   yes">&nbsp; </span>correlation with D2Mit423 as shown in the slide above.</font><br>
   </td>
  </tr>
  <tr>
   <td colspan=1></td>
   <td align=left colspan=1><br>
   </td>
  </tr>
  <tr>
   <td colspan=1></td>
   <td align=left colspan=1><font face=Verdana size=3>By clicking on the symbol
   D2Mit423 in the Correlation window, you will generate a new Trait Data
   window shown on the next slide.</font><br>
   </td>
  </tr>
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\ No newline at end of file
author	zsloan	2015-03-27 20:28:51 +0000
committer	zsloan	2015-03-27 20:28:51 +0000
commit	d0911a04958a04042da02a334ccc528dae79cc17 (patch)
tree	3c48e2e937c1dbeaf00a5697c87ed251afa5c8f1 /web/tutorial/ppt/WebQTLDemo_files/slide0059.htm
parent	a840ad18e1fe3db98a359a159e9b9b72367a2839 (diff)
download	genenetwork2-d0911a04958a04042da02a334ccc528dae79cc17.tar.gz