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author | Arun Isaac | 2023-12-29 18:55:37 +0000 |
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committer | Arun Isaac | 2023-12-29 19:01:46 +0000 |
commit | 204a308be0f741726b9a620d88fbc22b22124c81 (patch) | |
tree | b3cf66906674020b530c844c2bb4982c8a0e2d39 /gn2/wqflask/correlation/correlation_functions.py | |
parent | 83062c75442160427b50420161bfcae2c5c34c84 (diff) | |
download | genenetwork2-204a308be0f741726b9a620d88fbc22b22124c81.tar.gz |
Namespace all modules under gn2.
We move all modules under a gn2 directory. This is important for
"correct" packaging and deployment as a Guix service.
Diffstat (limited to 'gn2/wqflask/correlation/correlation_functions.py')
-rw-r--r-- | gn2/wqflask/correlation/correlation_functions.py | 68 |
1 files changed, 68 insertions, 0 deletions
diff --git a/gn2/wqflask/correlation/correlation_functions.py b/gn2/wqflask/correlation/correlation_functions.py new file mode 100644 index 00000000..911f6dc8 --- /dev/null +++ b/gn2/wqflask/correlation/correlation_functions.py @@ -0,0 +1,68 @@ +# Copyright (C) University of Tennessee Health Science Center, Memphis, TN. +# +# This program is free software: you can redistribute it and/or modify it +# under the terms of the GNU Affero General Public License +# as published by the Free Software Foundation, either version 3 of the +# License, or (at your option) any later version. +# +# This program is distributed in the hope that it will be useful, +# but WITHOUT ANY WARRANTY; without even the implied warranty of +# MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. +# See the GNU Affero General Public License for more details. +# +# This program is available from Source Forge: at GeneNetwork Project +# (sourceforge.net/projects/genenetwork/). +# +# Contact Drs. Robert W. Williams and Xiaodong Zhou (2010) +# at rwilliams@uthsc.edu and xzhou15@uthsc.edu +# +# +# +# This module is used by GeneNetwork project (www.genenetwork.org) +# +# Created by GeneNetwork Core Team 2010/08/10 + + +from gn2.base.mrna_assay_tissue_data import MrnaAssayTissueData +from gn3.computations.correlations import compute_corr_coeff_p_value +from gn2.wqflask.database import database_connection +from gn2.utility.tools import get_setting + +##################################################################################### +# Input: primaryValue(list): one list of expression values of one probeSet, +# targetValue(list): one list of expression values of one probeSet, +# method(string): indicate correlation method ('pearson' or 'spearman') +# Output: corr_result(list): first item is Correlation Value, second item is tissue number, +# third item is PValue +# Function: get correlation value,Tissue quantity ,p value result by using R; +# Note : This function is special case since both primaryValue and targetValue are from +# the same dataset. So the length of these two parameters is the same. They are pairs. +# Also, in the datatable TissueProbeSetData, all Tissue values are loaded based on +# the same tissue order +##################################################################################### + + +def cal_zero_order_corr_for_tiss(primary_values, target_values, method="pearson"): + """function use calls gn3 to compute corr,p_val""" + + (corr_coeff, p_val) = compute_corr_coeff_p_value( + primary_values=primary_values, target_values=target_values, corr_method=method) + + return (corr_coeff, len(primary_values), p_val) + +######################################################################################################## +# input: cursor, symbolList (list), dataIdDict(Dict): key is symbol +# output: SymbolValuePairDict(dictionary):one dictionary of Symbol and Value Pair. +# key is symbol, value is one list of expression values of one probeSet. +# function: wrapper function for getSymbolValuePairDict function +# build gene symbol list if necessary, cut it into small lists if necessary, +# then call getSymbolValuePairDict function and merge the results. +######################################################################################################## + + +def get_trait_symbol_and_tissue_values(symbol_list=None): + with database_connection(get_setting("SQL_URI")) as conn: + tissue_data = MrnaAssayTissueData(gene_symbols=symbol_list, conn=conn) + if len(tissue_data.gene_symbols) > 0: + results = tissue_data.get_symbol_values_pairs() + return results |