New parameter learning options

The main change here is in the parameter learning methods.  The parameters that are learned at first (i.e., if there is no evidence) are the distributions that are found directly in the data. I had to create or significantly modify several BNT files for this.

If there is evidence, the parameters are learned using a Dirichlet prior. This only required a couple of small changes to the BNW parameter learning files.

1 files changed, 3 insertions, 3 deletions

diff --git a/sourcecodes/BNW_workflow_net1.htm b/sourcecodes/BNW_workflow_net1.htm
index d69ddf84..318dd5c2 100644
--- a/sourcecodes/BNW_workflow_net1.htm
+++ b/sourcecodes/BNW_workflow_net1.htm
@@ -294,7 +294,7 @@ ul
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 **Recent updates to BNW may result in slight differences between what is described/shown below and what would currently be experienced in BNW.**<br><br>
 This tutorial provides
-an overview of using BNW to build a Bayesian network model from a dataset and use the network to make predictions. The dataset used in this tutorial is a synthetic example of a genetic dataset that has a total of 8 variables. Two of the variables are genotypes labeled Geno1 and Geno2, and the remaining 6 variables are gene expression levels or other quantitative traits that are labeled Trait1 to Trait6. The dataset is available <a href="example_datasets/example_data_8nodes.txt">here</a>.<br><br>The data file is formatted according to the guidelines on the <a href=http://compbio.uthsc.edu/BNW_1.12/sourcecodes/help.php#file_format>BNW help page</a>. The first row of the file contains the names of the variables and the remaining rows contain the data for each sample of the dataset. The genotypes (Geno1 and Geno2), which are the only discrete variables in the network, are the leftmost variables in the input file and are integer values (1 and 2) for all of the samples. The quantitative traits are continuous variables, and, therefore, all contain a "." in at least one of the samples.<o:p></o:p></span></p>
+an overview of using BNW to build a Bayesian network model from a dataset and use the network to make predictions. The dataset used in this tutorial is a synthetic example of a genetic dataset that has a total of 8 variables. Two of the variables are genotypes labeled Geno1 and Geno2, and the remaining 6 variables are gene expression levels or other quantitative traits that are labeled Trait1 to Trait6. The dataset is available <a href="example_datasets/example_data_8nodes.txt">here</a>.<br><br>The data file is formatted according to the guidelines on the <a href=http://compbio.uthsc.edu/BNW_1.2/sourcecodes/help.php#file_format>BNW help page</a>. The first row of the file contains the names of the variables and the remaining rows contain the data for each sample of the dataset. The genotypes (Geno1 and Geno2), which are the only discrete variables in the network, are the leftmost variables in the input file and are integer values (1 and 2) for all of the samples. The quantitative traits are continuous variables, and, therefore, all contain a "." in at least one of the samples.<o:p></o:p></span></p>
 
 <p class=MsoNormal style='margin-right:107.5pt'><b style='mso-bidi-font-weight:
 normal'><span style='font-size:14.0pt;line-height:115%;font-family:"Arial","sans-serif"'>1. Structure learning using default options<o:p></o:p></span></b></p>
@@ -324,7 +324,7 @@ normal'><span style='font-size:14.0pt;line-height:115%;font-family:"Arial","sans
 
 <p class=MsoNormal style='margin-top:0in;margin-right:107.5pt;margin-bottom:
 0in;margin-left:0in;margin-bottom:.0001pt'><span style='font-size:12.0pt;
-line-height:115%;font-family:"Arial","sans-serif";mso-no-proof:yes'>In order to test if edges present the single best scoring network are conserved across high scoring networks. We can modify the structure learning settings to get identify the structures of many high scoring networks and perform <a href=http://compbio.uthsc.edu/BNW_1.12/sourcecodes/help.php#learn_details>model averaging</a> over these structures. To do this, return to the BNW home page, select <u>Learn a network model from data</u>, and upload the datafile. Instead of using the default settings, select <u>Go to structure learning settings and the BNW structural constraint interface</u>. A more detailed overview of use of the structural constraint interface is provided in <a href=http://compbio.uthsc.edu/BNW_1.12/sourcecodes/BNW_workflow_2.htm>another tutorial</a>, but, here, we will investigate the impact of modifying some of the structure learning settings shown below:<br><o:p></o:p></span></p><br>
+line-height:115%;font-family:"Arial","sans-serif";mso-no-proof:yes'>In order to test if edges present the single best scoring network are conserved across high scoring networks. We can modify the structure learning settings to get identify the structures of many high scoring networks and perform <a href=http://compbio.uthsc.edu/BNW_1.2/sourcecodes/help.php#learn_details>model averaging</a> over these structures. To do this, return to the BNW home page, select <u>Learn a network model from data</u>, and upload the datafile. Instead of using the default settings, select <u>Go to structure learning settings and the BNW structural constraint interface</u>. A more detailed overview of use of the structural constraint interface is provided in <a href=http://compbio.uthsc.edu/BNW_1.2/sourcecodes/BNW_workflow_2.htm>another tutorial</a>, but, here, we will investigate the impact of modifying some of the structure learning settings shown below:<br><o:p></o:p></span></p><br>
 
 <p class=MsoNormal style='margin-right:107.5pt'><span style='font-size:12.0pt;
 line-height:115%;font-family:"Arial","sans-serif";mso-no-proof:yes'>
@@ -358,7 +358,7 @@ normal'><span style='font-size:14.0pt;line-height:115%;font-family:"Arial","sans
 
 <p class=MsoNormal style='margin-top:0in;margin-right:107.5pt;margin-bottom:
 0in;margin-left:0in;margin-bottom:.0001pt'><span style='font-size:12.0pt;
-line-height:115%;font-family:"Arial","sans-serif";mso-no-proof:yes'><br>To make predictions with the network, we will use the structure learned after model averaging of the top 100 highest scoring networks. First, we will use the model to compare the expected values for nodes in the network based on observed genotypes. For these predictions, we will keep the prediction in evidence mode. The difference between evidence and intervention modes is discussed in the <a href=http://compbio.uthsc.edu/BNW_1.12/sourcecodes/faq.php#evid_inter>BNW FAQ page</a>. To use the model to make predictions based on Geno1, click on one of the blue bars in the Geno1 node and enter 1 or 2 to indicate which genotype value should be used to predict the values of the other network nodes. In the figure below, Geno1 is outlined in red and state 2 has a 100% probability, indicating that the value of this node has been entered as evidence. The red lines in the figure show the predicted distributions of the nodes after this evidence is known and can be compared with the blue lines which show the distributions for variables using the original data.<o:p></o:p></span></p><br>
+line-height:115%;font-family:"Arial","sans-serif";mso-no-proof:yes'><br>To make predictions with the network, we will use the structure learned after model averaging of the top 100 highest scoring networks. First, we will use the model to compare the expected values for nodes in the network based on observed genotypes. For these predictions, we will keep the prediction in evidence mode. The difference between evidence and intervention modes is discussed in the <a href=http://compbio.uthsc.edu/BNW_1.2/sourcecodes/faq.php#evid_inter>BNW FAQ page</a>. To use the model to make predictions based on Geno1, click on one of the blue bars in the Geno1 node and enter 1 or 2 to indicate which genotype value should be used to predict the values of the other network nodes. In the figure below, Geno1 is outlined in red and state 2 has a 100% probability, indicating that the value of this node has been entered as evidence. The red lines in the figure show the predicted distributions of the nodes after this evidence is known and can be compared with the blue lines which show the distributions for variables using the original data.<o:p></o:p></span></p><br>
 
 <p class=MsoNormal style='margin-right:107.5pt'><span style='font-size:12.0pt;
 line-height:115%;font-family:"Arial","sans-serif";mso-no-proof:yes'>