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author | Pjotr Prins | 2017-08-03 10:26:52 +0000 |
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committer | Pjotr Prins | 2017-08-03 10:26:52 +0000 |
commit | 449d882a3b33ef81ef4f0127c3932b01fa796dbb (patch) | |
tree | 63a4031267b10f587b695adb487aca5213889b20 /src/bslmmdap.cpp | |
parent | d8db988550d4cd0303f0b82a75499c2c94d97d45 (diff) | |
download | pangemma-449d882a3b33ef81ef4f0127c3932b01fa796dbb.tar.gz |
LOCO is implemented in GEMMA for the BIMBAM format. Pass in the -loco
1 switch for LOCO of chromosome 1.
What are the use cases?
1. User runs vanilla GEMMA: all SNPs are considered input for GWA and K
2. User passes in -snps: all these SNPs are considered for GWA and K
3. User passes in -snps and -ksnps: All these SNPs are used for GWA,
Ksnps are used for K
4. User passes in -loco: SNPs are split by chromosome (GWA incl., K
excl.)
5. User passes in -snps, -gwasnps and -ksnps could mean that also GWA
is subset explicitely (nyi)
In all cases indicator_snp is honored and we get the most flexible way for
studying SNP combinations that can be passed in in different ways.
Overall added:
- various comments in source code
- tests in test framework inlc. fast-check
- NDEBUG compilation support in the Makefile
- -debug switch for GEMMA debug output
- debug.h which includes enforce functions which work like
assert. Unlike assert, enforce also works in release compilation
- -nind switch limit the number of individuals used
(trim_individuals for testing)
- enforcing tests of input files - e.g. are number of individuals correct
- checks for memory allocation - we should add more of those
- more checks for gsl results - we should add more of those
- replaced strtoken with regex as a first case. They should all be
replaced. strtoken is not thread safe, for one.
- introduced C++ iterators
- introduced C++ closure in BimBam LMM for cached processing
- more localized initialization of variables - makes for demonstratably
more correct code
- -ksnps adds snps into setKSnps
- -gwasnps adds snps into setGWASnps
- both sets are computed by -loco
- attempted to make the code easier to read
Diffstat (limited to 'src/bslmmdap.cpp')
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