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-rw-r--r--genenetwork/services/genecup.scm121
-rw-r--r--genenetwork/services/genenetwork.scm313
-rw-r--r--genenetwork/services/mouse-longevity.scm33
3 files changed, 406 insertions, 61 deletions
diff --git a/genenetwork/services/genecup.scm b/genenetwork/services/genecup.scm
new file mode 100644
index 0000000..6ee2812
--- /dev/null
+++ b/genenetwork/services/genecup.scm
@@ -0,0 +1,121 @@
+;;; genenetwork-machines --- Guix configuration for genenetwork machines
+;;; Copyright © 2024 jgart <jgart@dismail.de>
+;;;
+;;; This file is part of genenetwork-machines.
+;;;
+;;; genenetwork-machines is free software: you can redistribute it
+;;; and/or modify it under the terms of the GNU General Public License
+;;; as published by the Free Software Foundation, either version 3 of
+;;; the License, or (at your option) any later version.
+;;;
+;;; genenetwork-machines is distributed in the hope that it will be
+;;; useful, but WITHOUT ANY WARRANTY; without even the implied
+;;; warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.
+;;; See the GNU General Public License for more details.
+;;;
+;;; You should have received a copy of the GNU General Public License
+;;; along with genenetwork-machines.  If not, see
+;;; <https://www.gnu.org/licenses/>.
+
+(define-module (genenetwork services genecup)
+  #:use-module (guix)
+  #:use-module (gnu)
+  #:use-module (guix git)
+  #:use-module (guix modules)
+  #:use-module (guix profiles)
+  #:use-module (guix records)
+  #:use-module (srfi srfi-1)
+  #:use-module (ice-9 match)
+  #:use-module (forge utils)
+  #:use-module (gn packages genecup)
+  #:use-module (gn packages mouse-longevity)
+  #:use-module (gn services rshiny)
+  #:use-module (gn packages machine-learning)
+  #:use-module (gnu packages certs)
+  #:use-module (gnu packages curl)
+  #:use-module (gn packages python)
+  #:use-module (gnu packages admin)
+  #:use-module (gnu packages bioinformatics)
+  #:use-module (gnu packages compression)
+  #:use-module ((gnu packages python) #:select (python))
+  #:use-module (gnu packages python-xyz)
+  #:use-module (guix build python-build-system)
+  #:use-module (gnu packages python-crypto)
+  #:use-module (gnu packages python-web)
+  #:use-module (gnu services shepherd)
+  #:use-module (gnu packages python-science)
+  #:use-module (gnu packages machine-learning)
+  #:use-module ((gnu packages admin) #:select (shepherd))
+  #:export (genecup-configuration
+            genecup-configuration?
+            genecup-configuration-package
+            genecup-service-type))
+
+(define-record-type* <genecup-configuration>
+  genecup-configuration make-genecup-configuration
+  genecup-configuration?
+  (package genecup-configuration-package ; <package>
+           (default genecup-latest-with-tensorflow-native)))
+
+(define (genecup-activation config)
+  (match-record config <genecup-configuration>
+                (package)
+    (with-packages
+     (list python
+           python-nltk
+           nss-certs ; Needed for downloading data with nltk.downloader.
+           curl)
+     (with-imported-modules '((guix build utils))
+       #~(begin
+           (use-modules (guix build utils))
+           (let ((nltk-data "/var/cache/nltk_data/")
+                 (data-dir "/export/ratspub/tmp"))
+             (unless (file-exists? nltk-data)
+               (begin
+                 (mkdir-p nltk-data)
+                 (chdir nltk-data)
+                 (invoke #$(file-append python "/bin/python3") "-m" "nltk.downloader" "-d" nltk-data "punkt")))
+             (unless (file-exists? (string-append data-dir "/userspub.sqlite"))
+               (begin
+                 (install-file #$(file-append package "/userspub.sqlite") data-dir)
+                 (chmod (string-append data-dir "/userspub.sqlite") #o554)))))))))
+
+(define genecup-shepherd-service
+  (match-lambda
+    (($ <genecup-configuration> package)
+     (with-imported-modules (source-module-closure
+                             '((guix search-paths)
+                               (gnu build shepherd)
+                               (gnu system file-systems)))
+       (list (shepherd-service
+              (provision '(genecup))
+              (requirement '(networking))
+              (modules '((gnu build shepherd)
+                         (gnu system file-systems)))
+              (start
+               #~(make-forkexec-constructor
+                  (list #$(file-append package "/server.py"))
+                  #:directory #$package
+                  #:environment-variables
+                  (list
+                   "NLTK_DATA=/var/cache/nltk_data"
+                   (string-append "EDIRECT_PUBMED_MASTER="
+                                  #$(file-append package "/minipubmed"))
+                   (string-append "PERL_LWP_SSL_CA_FILE="
+                                  #$(file-append (profile (content (packages->manifest (list curl nss-certs))))
+                                                 "/etc/ssl/certs/ca-certificates.crt")))
+                  #:log-file "/var/log/genecup.log"))
+              (stop  #~(make-kill-destructor))))))))
+
+(define genecup-service-type
+  (service-type
+   (name 'genecup)
+   (extensions
+    (list
+     (service-extension activation-service-type
+                        genecup-activation)
+     (service-extension shepherd-root-service-type
+                        genecup-shepherd-service)))
+   (default-value (genecup-configuration))
+   (description
+    "Run a GeneCup Webserver.")))
diff --git a/genenetwork/services/genenetwork.scm b/genenetwork/services/genenetwork.scm
index ec3af23..b662005 100644
--- a/genenetwork/services/genenetwork.scm
+++ b/genenetwork/services/genenetwork.scm
@@ -21,18 +21,23 @@
 
 (define-module (genenetwork services genenetwork)
   #:use-module ((gn packages genenetwork) #:select (genenetwork2 genenetwork3 gn-auth gn-uploader))
+  #:use-module ((gn packages guile) #:select (gn-guile))
+  #:use-module (gnu build linux-container)
   #:use-module ((gnu packages web) #:select (nginx))
   #:use-module ((gnu packages admin) #:select (shadow shepherd))
+  #:use-module ((gnu packages version-control) #:select (git-minimal))
   #:use-module ((gnu packages python) #:select (python))
   #:use-module (gnu services)
   #:use-module (gnu services web)
   #:use-module (gnu services mcron)
+  #:use-module (gnu services shepherd)
   #:use-module (gnu system file-systems)
   #:use-module (gnu system shadow)
   #:use-module (guix build python-build-system)
   #:use-module (guix diagnostics)
   #:use-module (guix gexp)
   #:use-module (guix i18n)
+  #:use-module (guix least-authority)
   #:use-module (guix packages)
   #:use-module (guix profiles)
   #:use-module (guix records)
@@ -40,6 +45,7 @@
   #:use-module (forge nginx)
   #:use-module (forge gunicorn)
   #:use-module (forge socket)
+  #:use-module (forge utils)
   #:use-module (srfi srfi-1)
   #:use-module (ice-9 match)
   #:export (genenetwork-service-type
@@ -51,6 +57,7 @@
             genenetwork-configuration-port           ; external port
             genenetwork-configuration-gn2-port       ; internal port
             genenetwork-configuration-gn3-port       ; internal port
+            genenetwork-configuration-gn-guile-port  ; aka gn4 internal port (may be external)
             genenetwork-configuration-auth-db        ; RW auth DB
             genenetwork-configuration-xapian-db      ; RO search index, unless you want to regenerate inside VM
             genenetwork-configuration-genotype-files ; RO genotype files
@@ -103,12 +110,24 @@
                            (default "/var/empty"))
   (gn3-data-directory genenetwork-configuration-gn3-data-directory
                       (default "/var/genenetwork"))
+  (gn2-sessions-dir genenetwork-configuration-gn2-sessions-dir
+                    (default "/var/genenetwork/sessions/genenetwork2"))
   (gn2-secrets genenetwork-configuration-gn2-secrets
                (default "/etc/genenetwork"))
   (gn3-secrets genenetwork-configuration-gn3-secrets
                (default "/etc/genenetwork/gn3-secrets.py"))
   (gn-auth-secrets genenetwork-configuration-gn-auth-secrets
                    (default "/etc/genenetwork"))
+  (gn-guile genenetwork-configuration-gn-guile
+            (default gn-guile))
+  (gn-guile-port genenetwork-configuration-gn-guile-port
+                 (default 8091))
+  (gn-doc-git-checkout genenetwork-configuration-gn-doc-git-checkout
+                       (default "/export/data/gn-docs"))
+  (gn-virtuoso-ttl-directory genenetwork-configuration-gn-virtuoso-ttl-directory
+                             (default "/export/data/virtuoso/ttl"))
+  (gn-tmpdir genenetwork-configuration-gn-tmpdir
+             (default "/opt/gn/tmp"))
   (log-level genenetwork-configuration-log-level
              (default 'warning)
              (sanitize sanitize-log-level)))
@@ -132,6 +151,10 @@
                    (default "https://auth.genenetwork.org"))
   (gn2-server-url gn-uploader-configuration-gn2-server-url
                   (default "https://genenetwork.org"))
+  (sessions-dir gn-uploader-sessions-dir
+                (default "/var/genenetwork/sessions/gn-uploader"))
+  (sqlite-databases-directory gn-uploader-sqlite-databases-directory
+                              (default "/var/genenetwork/sqlite/gn-uploader"))
   (log-level gn-uploader-configuration-log-level
              (default 'warning)
              (sanitize sanitize-log-level)))
@@ -160,6 +183,8 @@
          (genenetwork3 (genenetwork-configuration-genenetwork3 config))
          (xapian-directory (genenetwork-configuration-xapian-db config))
          (sparql-endpoint (genenetwork-configuration-sparql-endpoint config))
+         (virtuoso-ttl-directory
+          (genenetwork-configuration-gn-virtuoso-ttl-directory config))
          (xapian-build-directory (string-append xapian-directory "/build"))
          (herd (file-append shepherd "/bin/herd"))
          (index-genenetwork (file-append genenetwork3 "/bin/index-genenetwork"))
@@ -193,7 +218,9 @@
                                                   "is-data-modified"
                                                   #$xapian-directory
                                                   #$sql-uri
-                                                  #$sparql-endpoint))))
+                                                  #$sparql-endpoint
+                                                  "--virtuoso-ttl-directory"
+                                                  #$virtuoso-ttl-directory))))
             (dynamic-wind
               (const #t)
               ;; build the index
@@ -202,7 +229,9 @@
                         "create-xapian-index"
                         #$xapian-build-directory
                         #$sql-uri
-                        #$sparql-endpoint)
+                        #$sparql-endpoint
+                        "--virtuoso-ttl-directory"
+                        #$virtuoso-ttl-directory)
                 (dynamic-wind
                   ;; stop GN3: Here there is magic!!!
                   ;;     The name `gunicorn-genenetwork' is magical. It is not set
@@ -230,36 +259,62 @@
                             (chmod file #o644))
                           (find-files #$xapian-directory)))))))))
 
-(define (make-non-human-data-public-cron-gexp config)
+(define (samples-count-script-gexp config)
   (match-record config <genenetwork-configuration>
-    (gn-auth sql-uri auth-db)
+                (genenetwork2 sql-uri)
     (with-imported-modules '((guix build utils))
       #~(begin
           (use-modules (guix build utils))
 
           (setenv "PYTHONPATH"
                   (string-append
-                   #$(file-append gn-auth
+                   #$(file-append genenetwork2
                                   "/lib/python"
                                   (python-version (package-version python))
                                   "/site-packages")
                    ":"
                    #$(profile
-                        (content (package->development-manifest gn-auth))
-                        (allow-collisions? #t))
+                       (content (package->development-manifest genenetwork2))
+                       (allow-collisions? #t))
                    "/lib/python"
                    #$(python-version (package-version python))
                    "/site-packages"))
 
           (invoke #$(file-append python "/bin/python3")
                   "-m"
-                  "scripts.batch_assign_data_to_default_admin"
-                  #$auth-db
+                  "gn2.scripts.sample_count"
                   #$sql-uri)))))
 
+(define (make-non-human-data-public-cron-gexp config)
+  (match-record config <genenetwork-configuration>
+                (gn-auth sql-uri auth-db)
+                (with-imported-modules '((guix build utils))
+                  #~(begin
+                      (use-modules (guix build utils))
+
+                      (setenv "PYTHONPATH"
+                              (string-append
+                               #$(file-append gn-auth
+                                              "/lib/python"
+                                              (python-version (package-version python))
+                                              "/site-packages")
+                               ":"
+                               #$(profile
+                                  (content (package->development-manifest gn-auth))
+                                  (allow-collisions? #t))
+                               "/lib/python"
+                               #$(python-version (package-version python))
+                               "/site-packages"))
+
+                      (invoke #$(file-append python "/bin/python3")
+                              "-m"
+                              "scripts.batch_assign_data_to_default_admin"
+                              #$auth-db
+                              #$sql-uri)))))
+
 (define (genenetwork-activation config)
   (match-record config <genenetwork-configuration>
-    (gn2-secrets gn3-secrets gn-auth-secrets auth-db)
+    (gn2-secrets gn3-secrets gn-auth-secrets auth-db llm-db-path genotype-files gn-tmpdir gn-doc-git-checkout gn2-sessions-dir)
     (with-imported-modules '((guix build utils))
       #~(begin
           (use-modules (guix build utils))
@@ -279,11 +334,19 @@
                              (passwd:uid (getpw "gunicorn-genenetwork2"))
                              (passwd:gid (getpw "gunicorn-genenetwork2"))))
                     (append (list #$gn2-secrets)
+                            (find-files #$genotype-files
+                                        #:directories? #t)
                             (find-files #$gn2-secrets
+                                        #:directories? #t)
+                            (find-files #$gn2-sessions-dir
                                         #:directories? #t)))
-          (chown #$gn3-secrets
-                 (passwd:uid (getpw "gunicorn-genenetwork3"))
-                 (passwd:gid (getpw "gunicorn-genenetwork3")))
+          (for-each (lambda (file)
+                      (chown file
+                             (passwd:uid (getpw "gunicorn-genenetwork3"))
+                             (passwd:gid (getpw "gunicorn-genenetwork3"))))
+                    (cons #$gn3-secrets
+                          (find-files #$(dirname llm-db-path)
+                                      #:directories? #t)))
           ;; Set owner-only permissions on secrets files.
           (for-each (lambda (file)
                       (chmod file #o600))
@@ -291,7 +354,31 @@
                             (find-files #$gn2-secrets
                                         #:directories? #f)
                             (find-files #$gn-auth-secrets
-                                        #:directories? #f)))))))
+                                        #:directories? #f)))
+          ;; Make sub-directories for various apps under gn-tmpdir and assign
+          ;; appropriate permissions
+          (for-each (match-lambda
+                      ((subdir user)
+                       (let ((full-path
+                              (string-append #$gn-tmpdir "/" subdir)))
+                         (unless (file-exists? full-path)
+                           (mkdir full-path #o755))
+                         (for-each (lambda (file)
+                                     (chown file
+                                            (passwd:uid (getpw user))
+                                            (passwd:gid (getpw user))))
+                                   (find-files full-path
+                                               #:directories? #t)))))
+                    '(("gn2-tmpdir" "gunicorn-genenetwork2")
+                      ("gn3-tmpdir" "gunicorn-genenetwork3")))
+
+          ;; setup correct ownership for gn-docs
+          (for-each (lambda (file)
+                      (chown file
+                             (passwd:uid (getpw "genenetwork"))
+                             (passwd:gid (getpw "genenetwork"))))
+                    (find-files #$(dirname gn-doc-git-checkout)
+                                #:directories? #t))))))
 
 (define (configuration-file-gexp alist)
   "Return a G-expression that constructs a configuration file of
@@ -322,7 +409,7 @@ G-expressions or numbers."
 described by @var{config}, a @code{<genenetwork-configuration>}
 object."
   (match-record config <genenetwork-configuration>
-    (genenetwork2 genenetwork3 gn-auth server-name gn-auth-server-name gn2-port gn3-port gn-auth-port sql-uri auth-db xapian-db genotype-files sparql-endpoint gn-sourcecode-directory gn3-data-directory gn2-secrets gn3-secrets gn-auth-secrets llm-db-path log-level)
+    (genenetwork2 genenetwork3 gn-auth server-name gn-auth-server-name gn2-port gn3-port gn-auth-port sql-uri auth-db xapian-db genotype-files gn2-sessions-dir sparql-endpoint gn-sourcecode-directory gn3-data-directory gn2-secrets gn3-secrets gn-auth-secrets llm-db-path gn-tmpdir log-level gn-guile-port)
     ;; If we mapped only the mysqld.sock socket file, it would break
     ;; when the external mysqld server is restarted.
     (let* ((database-mapping (file-system-mapping
@@ -341,12 +428,16 @@ object."
                                        ("GENENETWORK_FILES" ,genotype-files)
                                        ("GN3_LOCAL_URL" ,(string-append "http://localhost:"
                                                                         (number->string gn3-port)))
+                                       ("GN_GUILE_SERVER_URL" ,(string-append "http://localhost:" ; AKA GN4
+                                                                        (number->string gn-guile-port) "/" ))
                                        ("GN_SERVER_URL" ,(string-append "https://" server-name "/api3/"))
                                        ("AUTH_SERVER_URL" ,(string-append "https://" gn-auth-server-name "/"))
                                        ("JS_GUIX_PATH" ,(file-append gn2-profile "/share/genenetwork2/javascript"))
                                        ("PLINK_COMMAND" ,(file-append gn2-profile "/bin/plink2"))
                                        ("SQL_URI" ,sql-uri)
-                                       ("AI_SEARCH_ENABLED" "True")))))
+                                       ("AI_SEARCH_ENABLED" "True")
+                                       ("SESSION_FILESYSTEM_CACHE_PATH" ,gn2-sessions-dir)
+                                       ("MAX_FORM_MEMORY_SIZE" 52428800)))))
            (gn3-profile (profile
                          (content (package->development-manifest genenetwork3))
                          (allow-collisions? #t)))
@@ -355,6 +446,8 @@ object."
                                     (configuration-file-gexp
                                      `(("AUTH_DB" ,auth-db)
                                        ("AUTH_SERVER_URL" ,(string-append "https://" gn-auth-server-name "/"))
+                                       ("GN_GUILE_SERVER_URL" ,(string-append "http://localhost:" ; AKA GN4
+                                                                        (number->string gn-guile-port) "/"))
                                        ("DATA_DIR" ,gn3-data-directory)
                                        ("SOURCE_DIR" ,gn-sourcecode-directory)
                                        ("SPARQL_ENDPOINT" ,sparql-endpoint)
@@ -371,9 +464,9 @@ object."
                                         (configuration-file-gexp
                                          `(("GN_AUTH_SECRETS" ,(string-append gn-auth-secrets "/gn-auth-secrets.py"))
                                            ("AUTH_DB" ,auth-db)
-                                           ("SQL_URI" ,sql-uri)
-                                           ("CLIENTS_SSL_PUBLIC_KEYS_DIR" ,(string-append gn-auth-secrets "/clients-public-keys"))
-                                           ("SSL_PRIVATE_KEY" ,(string-append gn-auth-secrets "/gn-auth-ssl-private-key.pem")))))))
+                                           ("SQL_URI" ,sql-uri)))))
+           (gn2-tmpdir (string-append gn-tmpdir "/gn2-tmpdir"))
+           (gn3-tmpdir (string-append gn-tmpdir "/gn3-tmpdir")))
       (list (gunicorn-app
              (name "genenetwork2")
              (package genenetwork2)
@@ -388,7 +481,7 @@ object."
                      (value gn2-profile))
                     (environment-variable
                      (name "TMPDIR")
-                     (value "/tmp"))
+                     (value gn2-tmpdir))
                     (environment-variable
                      (name "GN2_SETTINGS")
                      (value gn2-conf))
@@ -401,13 +494,17 @@ object."
              (mappings (list database-mapping
                              (file-system-mapping
                               (source genotype-files)
-                              (target source))
+                              (target source)
+                              (writable? #t))
                              (file-system-mapping
                               (source gn-sourcecode-directory)
                               (target source))
-                             (file-system-mapping ; GN2 and GN3 need to share TMPDIR
-                              (source "/tmp")
-                              (target "/tmp")
+                             (file-system-mapping ; GN2 and GN3 need to communicate via TMPDIR
+                              (source gn-tmpdir)
+                              (target source))
+                             (file-system-mapping
+                              (source gn2-tmpdir)
+                              (target source)
                               (writable? #t))
                              (file-system-mapping
                               (source gn2-conf)
@@ -421,7 +518,11 @@ object."
                               (writable? #t))
                              (file-system-mapping
                               (source gn2-ca-bundle)
-                              (target source))))
+                              (target source))
+                             (file-system-mapping
+                              (source gn2-sessions-dir)
+                              (target source)
+                              (writable? #t))))
              (extra-cli-arguments
               (list "--log-level"
                     (string-upcase (symbol->string log-level)))))
@@ -442,7 +543,7 @@ object."
                      (value gn3-conf))
                     (environment-variable
                      (name "TMPDIR")
-                     (value "/tmp"))
+                     (value gn3-tmpdir))
                     (environment-variable
                      (name "GN3_SECRETS")
                      (value gn3-secrets))
@@ -468,15 +569,18 @@ object."
                              (file-system-mapping
                               (source gn3-data-directory)
                               (target source))    ; Rqtl usese this
-                             (file-system-mapping ; GN2 and GN3 need to share TMPDIR
-                              (source "/tmp")
-                              (target "/tmp")
+                             (file-system-mapping ; GN2 and GN3 need to communicate via TMPDIR
+                              (source gn-tmpdir)
+                              (target source))
+                             (file-system-mapping
+                              (source gn3-tmpdir)
+                              (target source)
                               (writable? #t))
                              (file-system-mapping
                               (source xapian-db)
                               (target source))
                              (file-system-mapping
-                              (source llm-db-path)
+                              (source (dirname llm-db-path))
                               (target source)
                               (writable? #t))
                              (file-system-mapping
@@ -492,6 +596,7 @@ object."
                              (port gn-auth-port))))
              (wsgi-app-module "gn_auth:create_app()")
              (workers 20)
+             (timeout 1200)
              (environment-variables
               (list (environment-variable
                      (name "GN_AUTH_CONF")
@@ -510,9 +615,9 @@ object."
                               (source gn-auth-conf)
                               (target source))
                              (file-system-mapping
-                              (source auth-db)
-                              (target source)
-                              (writable? #t))
+                               (source (dirname auth-db))
+                               (target source)
+                               (writable? #t))
                              (file-system-mapping
                               (source gn-auth-secrets)
                               (target source)
@@ -539,7 +644,8 @@ a @code{<genenetwork-configuration>} record."
                                               (number->string gn2-port) ";")
                                "proxy_set_header Host $host;"
                                "proxy_read_timeout 20m;"
-                               "proxy_set_header X-Forwarded-Proto $scheme;")))
+                               "proxy_set_header X-Forwarded-Proto $scheme;"
+                               "client_max_body_size 8050m;")))
                   (nginx-location-configuration
                    (uri "/api3/")
                    (body (list "rewrite /api3/(.*) /api/$1 break;"
@@ -569,11 +675,76 @@ a @code{<genenetwork-configuration>} record."
                #$(program-file "build-xapian-index-cron-gexp"
                                (build-xapian-index-cron-gexp config))
                #:user "root")
-        #~(job '(next-hour)
+        #~(job '(next-minute-from (next-hour) '(17)) ;17th minute of every hour
+               #$(program-file "samples-count-script-gexp"
+                               (samples-count-script-gexp config)))
+        #~(job '(next-minute (range 0 60 15))
                #$(program-file "make-non-human-data-public-cron-gexp"
                                (make-non-human-data-public-cron-gexp config))
-               #:user "gunicorn-gn-auth")
-        ))
+               #:user "gunicorn-gn-auth")))
+
+(define (gn-guile-gexp gn-guile-port gn-guile-pkg bare-repo)
+  (with-imported-modules '((guix build utils))
+    #~(begin
+        (use-modules (guix build utils))
+        (let* ((gn-guile-profile #$(profile (content (package->development-manifest gn-guile-pkg))
+                                            (allow-collisions? #t)))
+               (ssl-cert-dir (string-append gn-guile-profile "/etc/ssl/certs"))
+               (ssl-cert-file (string-append ssl-cert-dir "/ca-certificates.crt"))
+               (current-repo-path (string-append (pk "CWD" (getcwd)) "/gn-docs")))
+          ;; These have to be setup manually here an not in the
+          ;; `gn-guile-shepherd-service' function, otherwise, they do not take
+          ;; effect for some reason.
+          (setenv "SSL_CERT_DIR" ssl-cert-dir)
+          (setenv "SSL_CERT_FILE" ssl-cert-file)
+          (setenv "GUILE_TLS_CERTIFICATE_DIRECTORY" ssl-cert-dir)
+
+          (when (file-exists? current-repo-path)
+            (delete-file-recursively current-repo-path))
+          (setenv "CURRENT_REPO_PATH" current-repo-path)
+          (invoke #$(file-append git-minimal "/bin/git")
+                  "clone" "--depth" "1" #$(string-append "file://" bare-repo)))
+        (invoke #$(file-append gn-guile "/bin/gn-guile")
+                (number->string #$gn-guile-port)))))
+
+(define (gn-guile-shepherd-service config)
+  (match-record config <genenetwork-configuration>
+    (gn-guile gn-doc-git-checkout gn-guile-port)
+    (shepherd-service
+     (documentation "Run gn-guile server.")
+     (provision '(gn-guile))
+     (requirement '(networking))
+     (modules '((ice-9 match)
+                (srfi srfi-1)))
+     (start
+      (let* ((gn-guile-settings
+              `(("CGIT_REPO_PATH" ,gn-doc-git-checkout)
+                ("LC_ALL" "en_US.UTF-8")
+                ("GIT_COMMITTER_NAME" "genenetwork")
+                ("GIT_COMMITTER_EMAIL" "no-reply@git.genenetwork.org"))))
+        #~(make-forkexec-constructor
+	   (list #$(least-authority-wrapper
+                    (program-file "gn-guile"
+                                  (gn-guile-gexp gn-guile-port gn-guile gn-doc-git-checkout))
+                    #:name "gn-guile-pola-wrapper"
+                    #:directory (dirname gn-doc-git-checkout)
+                    #:preserved-environment-variables
+                    (map first gn-guile-settings)
+                    #:mappings (list (file-system-mapping
+                                       (source (dirname gn-doc-git-checkout))
+                                       (target source)
+                                       (writable? #t)))
+                    #:namespaces (delq 'net %namespaces))
+                 "127.0.0.1" #$(number->string gn-guile-port))
+           #:user "genenetwork"
+           #:group "genenetwork"
+           #:environment-variables
+           (map (match-lambda
+                  ((spec value)
+                   (string-append spec "=" value)))
+                '#$gn-guile-settings)
+	   #:log-file "/var/log/gn-guile.log")))
+     (stop #~(make-kill-destructor)))))
 
 (define genenetwork-service-type
   (service-type
@@ -588,19 +759,27 @@ a @code{<genenetwork-configuration>} record."
                              genenetwork-gunicorn-apps)
           (service-extension forge-nginx-service-type
                              genenetwork-nginx-server-blocks)
+          (service-extension shepherd-root-service-type
+                             (compose list gn-guile-shepherd-service))
           (service-extension mcron-service-type genenetwork-mcron-jobs)))
    (default-value (genenetwork-configuration))))
 
 (define (gn-uploader-activation config)
   (match-record config <gn-uploader-configuration>
-    (secrets data-directory)
+    (secrets data-directory sessions-dir sqlite-databases-directory)
     (with-imported-modules '((guix build utils))
       #~(begin
           (use-modules (guix build utils))
           ;; Let service user own their own secrets files.
-          (chown #$secrets
-                 (passwd:uid (getpw "gunicorn-gn-uploader"))
-                 (passwd:gid (getpw "gunicorn-gn-uploader")))
+          (for-each (lambda (file)
+                      (chown file
+                             (passwd:uid (getpw "gunicorn-gn-uploader"))
+                             (passwd:gid (getpw "gunicorn-gn-uploader"))))
+                    (append (list #$(dirname secrets))
+                            (find-files #$sessions-dir
+                                        #:directories? #t)
+                            (find-files #$sqlite-databases-directory
+                                        #:directories? #t)))
           ;; Set owner-only permissions on secrets files.
           (for-each (lambda (file)
                       (chmod file #o600))
@@ -616,25 +795,27 @@ a @code{<genenetwork-configuration>} record."
 
 (define (gn-uploader-gunicorn-app config)
   (match-record config <gn-uploader-configuration>
-    (gn-uploader sql-uri port data-directory secrets log-level auth-server-url gn2-server-url)
+    (gn-uploader sql-uri port data-directory secrets log-level auth-server-url gn2-server-url sessions-dir sqlite-databases-directory)
     ;; If we mapped only the mysqld.sock socket file, it would break
     ;; when the external mysqld server is restarted.
-    (let ((database-mapping (file-system-mapping
-                             (source "/run/mysqld")
-                             (target source)
-                             (writable? #t)))
-          (gn-uploader-conf (computed-file "gn-uploader.conf"
-                                           (configuration-file-gexp
-                                            `(("UPLOADER_SECRETS" ,secrets)
-                                              ("SQL_URI" ,sql-uri)
-                                              ("UPLOAD_FOLDER" ,(string-append data-directory
-                                                                               "/uploads"))
-                                              ("AUTH_SERVER_URL" ,auth-server-url)
-                                              ("GN2_SERVER_URL" ,gn2-server-url)))))
-          (gn-uploader-profile (profile
-                                (content (package->development-manifest gn-uploader))
-                                (allow-collisions? #t)))
-          (gn-uploader-ca-bundle (file-append gn-uploader-profile "/etc/ssl/certs/ca-certificates.crt")))
+    (let* ((database-mapping (file-system-mapping
+                              (source "/run/mysqld")
+                              (target source)
+                              (writable? #t)))
+           (gn-uploader-conf (computed-file "gn-uploader.conf"
+                                            (configuration-file-gexp
+                                             `(("UPLOADER_SECRETS" ,secrets)
+                                               ("SQL_URI" ,sql-uri)
+                                               ("UPLOAD_FOLDER" ,(string-append data-directory
+                                                                                "/uploads"))
+                                               ("AUTH_SERVER_URL" ,auth-server-url)
+                                               ("GN2_SERVER_URL" ,gn2-server-url)
+                                               ("SESSION_FILESYSTEM_CACHE_PATH" ,sessions-dir)
+                                               ("ASYNCHRONOUS_JOBS_SQLITE_DB" ,(string-append sqlite-databases-directory "/background-jobs.db"))))))
+           (gn-uploader-profile (profile
+                                 (content (package->development-manifest gn-uploader))
+                                 (allow-collisions? #t)))
+           (gn-uploader-ca-bundle (file-append gn-uploader-profile "/etc/ssl/certs/ca-certificates.crt")))
       (list (gunicorn-app
              (name "gn-uploader")
              (package gn-uploader)
@@ -642,6 +823,7 @@ a @code{<genenetwork-configuration>} record."
                              (port port))))
              (wsgi-app-module "scripts.qcapp_wsgi:app")
              (workers 20)
+             (timeout 1200)
              (environment-variables
               (list (environment-variable
                      (name "UPLOADER_CONF")
@@ -660,8 +842,9 @@ a @code{<genenetwork-configuration>} record."
                               (source gn-uploader-conf)
                               (target source))
                              (file-system-mapping
-                              (source secrets)
-                              (target source))
+                              (source (dirname secrets))
+                              (target source)
+                              (writable? #t))
                              (file-system-mapping
                               (source data-directory)
                               (target source)
@@ -671,7 +854,15 @@ a @code{<genenetwork-configuration>} record."
                               (target source))
                              (file-system-mapping
                               (source gn-uploader-ca-bundle)
-                              (target source))))
+                              (target source))
+                             (file-system-mapping
+                              (source sessions-dir)
+                              (target source)
+                              (writable? #t))
+                             (file-system-mapping
+                              (source sqlite-databases-directory)
+                              (target source)
+                              (writable? #t))))
              (extra-cli-arguments
               (list "--log-level"
                     (string-upcase (symbol->string log-level)))))))))
diff --git a/genenetwork/services/mouse-longevity.scm b/genenetwork/services/mouse-longevity.scm
new file mode 100644
index 0000000..c9b977d
--- /dev/null
+++ b/genenetwork/services/mouse-longevity.scm
@@ -0,0 +1,33 @@
+;;; genenetwork-machines --- Guix configuration for genenetwork machines
+;;; Copyright © 2024 jgart <jgart@dismail.de>
+;;;
+;;; This file is part of genenetwork-machines.
+;;;
+;;; genenetwork-machines is free software: you can redistribute it
+;;; and/or modify it under the terms of the GNU General Public License
+;;; as published by the Free Software Foundation, either version 3 of
+;;; the License, or (at your option) any later version.
+;;;
+;;; genenetwork-machines is distributed in the hope that it will be
+;;; useful, but WITHOUT ANY WARRANTY; without even the implied
+;;; warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.
+;;; See the GNU General Public License for more details.
+;;;
+;;; You should have received a copy of the GNU General Public License
+;;; along with genenetwork-machines.  If not, see
+;;; <https://www.gnu.org/licenses/>.
+
+(define-module (genenetwork services mouse-longevity)
+  #:use-module (gn packages genecup)
+  #:use-module (gn packages mouse-longevity)
+  #:use-module (gn services rshiny)
+  #:use-module (gnu services)
+  #:export (mouse-longevity-service))
+
+(define* (mouse-longevity-service #:optional (package mouse-longevity-app))
+  (simple-service 'mouse-longevity
+                  rshiny-service-type
+                  (list 
+                    (rshiny-configuration
+                      (package package)
+                      (binary "mouse-longevity-app")))))