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+                    GNU GENERAL PUBLIC LICENSE
+                       Version 3, 29 June 2007
+
+ Copyright (C) 2007 Free Software Foundation, Inc. <https://fsf.org/>
+ Everyone is permitted to copy and distribute verbatim copies
+ of this license document, but changing it is not allowed.
+
+                            Preamble
+
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+  16. Limitation of Liability.
+
+  IN NO EVENT UNLESS REQUIRED BY APPLICABLE LAW OR AGREED TO IN WRITING
+WILL ANY COPYRIGHT HOLDER, OR ANY OTHER PARTY WHO MODIFIES AND/OR CONVEYS
+THE PROGRAM AS PERMITTED ABOVE, BE LIABLE TO YOU FOR DAMAGES, INCLUDING ANY
+GENERAL, SPECIAL, INCIDENTAL OR CONSEQUENTIAL DAMAGES ARISING OUT OF THE
+USE OR INABILITY TO USE THE PROGRAM (INCLUDING BUT NOT LIMITED TO LOSS OF
+DATA OR DATA BEING RENDERED INACCURATE OR LOSSES SUSTAINED BY YOU OR THIRD
+PARTIES OR A FAILURE OF THE PROGRAM TO OPERATE WITH ANY OTHER PROGRAMS),
+EVEN IF SUCH HOLDER OR OTHER PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF
+SUCH DAMAGES.
+
+  17. Interpretation of Sections 15 and 16.
+
+  If the disclaimer of warranty and limitation of liability provided
+above cannot be given local legal effect according to their terms,
+reviewing courts shall apply local law that most closely approximates
+an absolute waiver of all civil liability in connection with the
+Program, unless a warranty or assumption of liability accompanies a
+copy of the Program in return for a fee.
+
+                     END OF TERMS AND CONDITIONS
+
+            How to Apply These Terms to Your New Programs
+
+  If you develop a new program, and you want it to be of the greatest
+possible use to the public, the best way to achieve this is to make it
+free software which everyone can redistribute and change under these terms.
+
+  To do so, attach the following notices to the program.  It is safest
+to attach them to the start of each source file to most effectively
+state the exclusion of warranty; and each file should have at least
+the "copyright" line and a pointer to where the full notice is found.
+
+    <one line to give the program's name and a brief idea of what it does.>
+    Copyright (C) <year>  <name of author>
+
+    This program is free software: you can redistribute it and/or modify
+    it under the terms of the GNU General Public License as published by
+    the Free Software Foundation, either version 3 of the License, or
+    (at your option) any later version.
+
+    This program is distributed in the hope that it will be useful,
+    but WITHOUT ANY WARRANTY; without even the implied warranty of
+    MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
+    GNU General Public License for more details.
+
+    You should have received a copy of the GNU General Public License
+    along with this program.  If not, see <https://www.gnu.org/licenses/>.
+
+Also add information on how to contact you by electronic and paper mail.
+
+  If the program does terminal interaction, make it output a short
+notice like this when it starts in an interactive mode:
+
+    <program>  Copyright (C) <year>  <name of author>
+    This program comes with ABSOLUTELY NO WARRANTY; for details type `show w'.
+    This is free software, and you are welcome to redistribute it
+    under certain conditions; type `show c' for details.
+
+The hypothetical commands `show w' and `show c' should show the appropriate
+parts of the General Public License.  Of course, your program's commands
+might be different; for a GUI interface, you would use an "about box".
+
+  You should also get your employer (if you work as a programmer) or school,
+if any, to sign a "copyright disclaimer" for the program, if necessary.
+For more information on this, and how to apply and follow the GNU GPL, see
+<https://www.gnu.org/licenses/>.
+
+  The GNU General Public License does not permit incorporating your program
+into proprietary programs.  If your program is a subroutine library, you
+may consider it more useful to permit linking proprietary applications with
+the library.  If this is what you want to do, use the GNU Lesser General
+Public License instead of this License.  But first, please read
+<https://www.gnu.org/licenses/why-not-lgpl.html>.
diff --git a/genenetwork-development-deploy.sh b/genenetwork-development-deploy.sh
new file mode 100755
index 0000000..8d9d1ab
--- /dev/null
+++ b/genenetwork-development-deploy.sh
@@ -0,0 +1,36 @@
+#! /bin/sh -e
+
+# genenetwork-machines --- Guix configuration for genenetwork machines
+# Copyright © 2022 Arun Isaac <arunisaac@systemreboot.net>
+#
+# This file is part of genenetwork-machines.
+#
+# genenetwork-machines is free software: you can redistribute it
+# and/or modify it under the terms of the GNU General Public License
+# as published by the Free Software Foundation, either version 3 of
+# the License, or (at your option) any later version.
+#
+# genenetwork-machines is distributed in the hope that it will be
+# useful, but WITHOUT ANY WARRANTY; without even the implied warranty
+# of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the GNU
+# General Public License for more details.
+#
+# You should have received a copy of the GNU General Public License
+# along with genenetwork-machines.  If not, see
+# <https://www.gnu.org/licenses/>.
+
+# Build and install genenetwork development container on penguin2.
+
+container_script=$(guix system container --network \
+                        --verbosity=3 \
+                        --load-path=. \
+                        --share=/var/guix/daemon-socket=/var/host-guix/daemon-socket \
+                        --share=/var/guix-containers/genenetwork-development/var/lib/laminar=/var/lib/laminar \
+                        --expose=/export/data/genenetwork/genotype_files \
+                        --share=/export/genenetwork-database-dump \
+                        --share=/var/run/mysqld/mysqld.sock=/run/mysqld/mysqld.sock \
+                        --share=/var/guix-containers/genenetwork-development/srv/http=/srv/http \
+                        genenetwork-development.scm)
+
+echo $container_script
+sudo ln --force --symbolic $container_script /usr/local/bin/genenetwork-development-container
diff --git a/genenetwork-development.scm b/genenetwork-development.scm
new file mode 100644
index 0000000..2465573
--- /dev/null
+++ b/genenetwork-development.scm
@@ -0,0 +1,650 @@
+;;; genenetwork-machines --- Guix configuration for genenetwork machines
+;;; Copyright © 2022 Arun Isaac <arunisaac@systemreboot.net>
+;;;
+;;; This file is part of genenetwork-machines.
+;;;
+;;; genenetwork-machines is free software: you can redistribute it
+;;; and/or modify it under the terms of the GNU General Public License
+;;; as published by the Free Software Foundation, either version 3 of
+;;; the License, or (at your option) any later version.
+;;;
+;;; genenetwork-machines is distributed in the hope that it will be
+;;; useful, but WITHOUT ANY WARRANTY; without even the implied
+;;; warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.
+;;; See the GNU General Public License for more details.
+;;;
+;;; You should have received a copy of the GNU General Public License
+;;; along with genenetwork-machines.  If not, see
+;;; <https://www.gnu.org/licenses/>.
+
+(use-modules (gnu)
+             ((gn packages gemini) #:select (tissue))
+             ((gn packages genenetwork) #:select (genenetwork2 genenetwork3))
+             ((gn packages quality-control) #:select (sbcl-qc))
+             (gn services databases)
+             ((gnu packages admin) #:select (shepherd))
+             ((gnu packages base) #:select (gnu-make))
+             ((gnu packages bash) #:select (bash))
+             ((gnu packages bioinformatics) #:select (ccwl) #:prefix guix:)
+             ((gnu packages certs) #:select (nss-certs))
+             ((gnu packages check) #:select (python-pylint))
+             ((gnu packages ci) #:select (laminar))
+             ((gnu packages gnupg) #:select (guile-gcrypt))
+             ((gnu packages graphviz) #:select (graphviz))
+             ((gnu packages guile) #:select (guile-3.0 guile-zlib))
+             ((gnu packages guile-xyz) #:select (guile-dbd-mysql guile-dbi guile-libyaml))
+             ((gnu packages guile-xyz) #:select (guile-sparql) #:prefix guix:)
+             ((gnu packages haskell-apps) #:select (shellcheck))
+             ((gnu packages python-check) #:select (python-mypy))
+             ((gnu packages python-web) #:select (gunicorn))
+             ((gnu packages tls) #:select (openssl))
+             ((gnu packages version-control) #:select (git-minimal))
+             (gnu services ci)
+             (gnu services databases)
+             (gnu services shepherd)
+             (guix build-system gnu)
+             (guix git-download)
+             ((guix licenses) #:prefix license:)
+             (guix modules)
+             (guix packages)
+             (guix profiles)
+             (guix records)
+             (guix store)
+             (forge forge)
+             (forge laminar)
+             (forge utils)
+             (forge webhook)
+             (srfi srfi-1)
+             (ice-9 match))
+
+;; guix-daemon socket of the host shared inside the container
+(define %guix-daemon-uri
+  "/var/host-guix/daemon-socket/socket")
+
+(define (manifest-cons package onto-manifest)
+  "Return a manifest with PACKAGE and all packages in ONTO-MANIFEST."
+  (manifest (cons (package->manifest-entry package)
+                  (manifest-entries onto-manifest))))
+
+(define (manifest-cons* . args)
+  "ARGS is of the form (PACKAGES ... ONTO-MANIFEST). Return a manifest
+with PACKAGES and all packages in ONTO-MANIFEST."
+  (let ((packages (drop-right args 1))
+        (onto-manifest (last args)))
+    (manifest (append (map package->manifest-entry packages)
+                      (manifest-entries onto-manifest)))))
+
+(define (import-module? name)
+  "Return #t if NAME, a list of symbols, denotes a module that should
+be imported into G-expressions."
+  ;; Allow all guix-forge, genenetwork or guix modules.
+  (match name
+    (((or 'forge 'genenetwork) _ ...) #t)
+    (name (guix-module-name? name))))
+
+
+;;;
+;;; Development server configuration
+;;;
+
+;; A development server is a server that is automatically redeployed
+;; on every commit to its git repository. This is used by both the
+;; genenetwork2 and the genenetwork3 development servers. Here, we
+;; abstract out the details.
+
+(define-record-type* <development-server-configuration>
+  development-server-configuration make-development-server-configuration
+  development-server-configuration?
+  (name development-server-configuration-name)
+  (git-repository development-server-configuration-git-repository)
+  (git-branch development-server-configuration-git-branch)
+  (executable-path development-server-configuration-executable-path)
+  (runner development-server-configuration-runner)
+  (port development-server-configuration-port
+        (default 8080)))
+
+(define (development-server-redeploy config)
+  "Return a G-expression that provides a function redeploy which
+redeploys the development server specified by CONFIG, a
+<development-server-configuration> object."
+  (with-imported-modules (source-module-closure '((genenetwork development-helper)
+                                                  (forge build git))
+                                                #:select? import-module?)
+    (with-extensions (list guile-gcrypt guile-zlib)
+      (with-packages (list git-minimal nss-certs)
+        #~(begin
+            (use-modules (genenetwork development-helper)
+                         (forge build git)
+                         (guix derivations)
+                         (guix gexp)
+                         (guix monads)
+                         (guix store)
+                         (guix utils)
+                         (rnrs exceptions))
+            
+            (define (redeploy)
+              (parameterize ((%daemon-socket-uri #$%guix-daemon-uri))
+                (switch-symlinks
+                 #$(development-server-configuration-executable-path config)
+                 (with-store store
+                   (run-with-store store
+                     (mlet* %store-monad ((latest-source
+                                           (latest-git-checkout
+                                            #$(string-append (development-server-configuration-name config)
+                                                             "-checkout")
+                                            #$(development-server-configuration-git-repository config)
+                                            #:branch #$(development-server-configuration-git-branch config)))
+                                          (runner-drv
+                                           (gexp->script
+                                            #$(string-append (development-server-configuration-name config)
+                                                             "-runner")
+                                            (#$(development-server-configuration-runner config)
+                                             latest-source)
+                                            #:guile (read-derivation-from-file
+                                                     #$(raw-derivation-file
+                                                        (with-store store
+                                                          (package-derivation store guile-3.0)))))))
+                       (mbegin %store-monad
+                         (built-derivations (list runner-drv))
+                         (return (derivation->output-path runner-drv))))))))))))))
+
+(define (development-server-activation config)
+  "Return a G-expression that runs the development server specified by
+CONFIG, a <development-server-configuration> object, on startup."
+  (let ((executable-path (development-server-configuration-executable-path config)))
+    #~(begin
+        (use-modules (guix build utils))
+      
+        (mkdir-p #$(dirname executable-path))
+        (chown #$(dirname executable-path)
+               (passwd:uid (getpw "laminar"))
+               (passwd:gid (getpw "laminar")))
+        #$(development-server-redeploy config)
+        (redeploy))))
+
+
+;;;
+;;; genenetwork2
+;;;
+
+;; Path to genotype files required by genenetwork2
+(define %genotype-files
+  "/export/data/genenetwork/genotype_files")
+
+;; Port on which genenetwork3 is listening
+(define %genenetwork3-port
+  9093)
+
+(define (genenetwork2-tests project test-command)
+  "Return a G-expression that runs TEST-COMMAND with genenetwork2
+source code. PROJECT is a <forge-project> object describing
+genenetwork2. TEST-COMMAND is a list of strings specifying the command
+to be executed."
+  (with-imported-modules '((guix build utils))
+    (with-packages (list bash coreutils git-minimal nss-certs)
+      #~(begin
+          (use-modules (guix build utils))
+
+          (define (hline)
+            "Print a horizontal line 50 '=' characters long."
+            (display (make-string 50 #\=))
+            (newline)
+            (force-output))
+          
+          (invoke "git" "clone" "--depth" "1"
+                  "--branch" #$(forge-project-repository-branch project)
+                  #$(forge-project-repository project)
+                  ".")
+          (hline)
+          (invoke "git" "log" "--max-count" "1")
+          (hline)
+          (setenv "SERVER_PORT" "8080")
+          (setenv "GN2_PROFILE"
+                  #$(profile
+                     (content (package->development-manifest genenetwork2))
+                     (allow-collisions? #t)))
+          (setenv "GN_PROXY_URL" "http://genenetwork.org/gn3-proxy")
+          (setenv "GN3_LOCAL_URL" "http://localhost:9093")
+          (setenv "GENENETWORK_FILES" #$%genotype-files)
+          (setenv "HOME" "/tmp")
+          (setenv "SQL_URI" "mysql://webqtlout:webqtlout@localhost/db_webqtl")
+          (apply invoke '#$test-command)))))
+
+(define (genenetwork2-project config)
+  "Return a forge project describing genenetwork2. CONFIG is a
+<development-server-configuration> object describing genenetwork2."
+  (forge-project
+   (name "genenetwork2")
+   (repository (development-server-configuration-git-repository config))
+   (repository-branch (development-server-configuration-git-branch config))
+   (ci-jobs (list (forge-laminar-job
+                   (name "genenetwork2")
+                   (run (genenetwork2-tests
+                         this-forge-project
+                         (list "sh" "bin/genenetwork2" "./etc/default_settings.py"
+                               "-c" "-m" "unittest" "-v")))
+                   ;; If unit tests pass, redeploy genenetwork2.
+                   (after #~(begin
+                              (use-modules (guix build utils))
+                              #$(development-server-redeploy config)
+                              (when (string=? (getenv "RESULT") "success")
+                                (redeploy)
+                                ;; We cannot refer to sudo in the
+                                ;; store since that sudo does not have
+                                ;; the setuid bit set. See "(guix)
+                                ;; Setuid Programs".
+                                (invoke "/run/setuid-programs/sudo"
+                                        #$(file-append shepherd "/bin/herd")
+                                        "restart" "genenetwork2")
+                                (invoke #$(file-append laminar "/bin/laminarc")
+                                        "queue" "genenetwork2-mechanical-rob")))))
+                  (forge-laminar-job
+                   (name "genenetwork2-mechanical-rob")
+                   (run (genenetwork2-tests
+                         this-forge-project
+                         (list "sh" "bin/genenetwork2" "./etc/default_settings.py"
+                               "-c" "../test/requests/test-website.py"
+                               "--all" "http://localhost:9092")))
+                   (trigger? #f))))
+   (ci-jobs-trigger 'webhook)))
+
+(define (genenetwork2-shepherd-service config)
+  "Return a shepherd service to run the genenetwork2 development
+server. CONFIG is a <development-server-configuration> object
+describing genenetwork2."
+  (shepherd-service
+   (documentation "Run GeneNetwork 2 development server.")
+   (provision '(genenetwork2))
+   ;; FIXME: The genenetwork2 service should depend on redis.
+   (requirement '(networking genenetwork3))
+   (modules '((gnu build shepherd)
+              (gnu system file-systems)))
+   (start
+    (with-imported-modules (source-module-closure '((gnu build shepherd)
+                                                    (gnu system file-systems)))
+      #~(make-forkexec-constructor/container
+         (list #$(development-server-configuration-executable-path config)
+               "127.0.0.1" (number->string #$(development-server-configuration-port config)))
+         #:mappings (list (file-system-mapping
+                           (source #$(development-server-configuration-executable-path config))
+                           (target source))
+                          (file-system-mapping
+                           (source #$%genotype-files)
+                           (target source))
+                          (file-system-mapping
+                           (source "/run/mysqld/mysqld.sock")
+                           (target source)
+                           (writable? #t)))
+         #:log-file "/var/log/genenetwork2.log")))
+   (stop #~(make-kill-destructor))))
+
+(define %default-genenetwork2-configuration
+  (development-server-configuration
+   (name "genenetwork2")
+   (git-repository "https://github.com/genenetwork/genenetwork2")
+   (git-branch "testing")
+   (executable-path "/laminar/bin/genenetwork2")
+   (runner (with-imported-modules (source-module-closure '((genenetwork development-helper))
+                                                         #:select? import-module?)
+             #~(lambda (latest-gn2-source)
+                 ((@@ (genenetwork development-helper) genenetwork2-runner-gexp)
+                  latest-gn2-source
+                  #$(profile
+                     (content (package->development-manifest genenetwork2))
+                     (allow-collisions? #t))
+                  #$%genenetwork3-port
+                  #$%genotype-files))))))
+
+(define genenetwork2-service-type
+  (service-type
+   (name 'genenetwork2)
+   (description "Run GeneNetwork 2 development server and CI.")
+   (extensions
+    (list (service-extension activation-service-type
+                             development-server-activation)
+          (service-extension shepherd-root-service-type
+                             (compose list genenetwork2-shepherd-service))
+          (service-extension forge-service-type
+                             (compose list genenetwork2-project))))
+   (default-value %default-genenetwork2-configuration)))
+
+
+;;;
+;;; genenetwork3
+;;;
+
+(define (genenetwork3-tests tests-command manifest)
+  "Return a G-expression running TESTS-COMMAND in a profile described
+by MANIFEST with the latest git checkout of genenetwork3 as the
+current directory. TESTS-COMMAND is a list of strings specifying the
+command to be executed."
+  (with-imported-modules (source-module-closure '((genenetwork development-helper))
+                                                #:select? import-module?)
+    #~(lambda (genenetwork3-checkout)
+        ((@@ (genenetwork development-helper)
+             command-in-source-gexp)
+         genenetwork3-checkout
+         #$(profile
+            (content manifest)
+            (allow-collisions? #t))
+         '#$tests-command))))
+
+(define genenetwork3-unit-tests
+  (genenetwork3-tests (list "python3" "-m" "unittest")
+                      (package->development-manifest genenetwork3)))
+
+(define genenetwork3-pylint
+  (with-imported-modules (source-module-closure '((genenetwork development-helper))
+                                                #:select? import-module?)
+    #~(lambda (genenetwork3-checkout)
+        ((@@ (genenetwork development-helper)
+             genenetwork3-lint-gexp)
+         genenetwork3-checkout
+         #$(profile
+            (content (manifest-cons* python-pylint shellcheck
+                                     (package->development-manifest genenetwork3)))
+            (allow-collisions? #t))))))
+
+(define genenetwork3-mypy
+  (genenetwork3-tests (list "mypy" ".")
+                      (manifest-cons python-mypy
+                                     (package->development-manifest genenetwork3))))
+
+(define (genenetwork3-project config)
+  (forge-project
+   (name "genenetwork3")
+   (repository (development-server-configuration-git-repository config))
+   (repository-branch (development-server-configuration-git-branch config))
+   (ci-jobs (list (forge-laminar-job
+                   (name "genenetwork3")
+                   (run (derivation-job-gexp
+                         this-forge-project
+                         this-forge-laminar-job
+                         genenetwork3-unit-tests
+                         #:guix-daemon-uri %guix-daemon-uri))
+                   ;; If unit tests pass, redeploy genenetwork3.
+                   (after #~(begin
+                              (use-modules (guix build utils))
+                              #$(development-server-redeploy config)
+                              (when (string=? (getenv "RESULT") "success")
+                                (redeploy)
+                                ;; We cannot refer to sudo in the
+                                ;; store since that sudo does not have
+                                ;; the setuid bit set. See "(guix)
+                                ;; Setuid Programs".
+                                (invoke "/run/setuid-programs/sudo"
+                                        #$(file-append shepherd "/bin/herd")
+                                        "restart" "genenetwork3")))))
+                  (forge-laminar-job
+                   (name "genenetwork3-pylint")
+                   (run (derivation-job-gexp
+                         this-forge-project
+                         this-forge-laminar-job
+                         genenetwork3-pylint
+                         #:guix-daemon-uri %guix-daemon-uri)))
+                  (forge-laminar-job
+                   (name "genenetwork3-mypy")
+                   (run (derivation-job-gexp
+                         this-forge-project
+                         this-forge-laminar-job
+                         genenetwork3-mypy
+                         #:guix-daemon-uri %guix-daemon-uri)))))
+   (ci-jobs-trigger 'webhook)))
+
+(define (genenetwork3-shepherd-service config)
+  (shepherd-service
+   (documentation "Run GeneNetwork 3.")
+   (provision '(genenetwork3))
+   (requirement '(networking))
+   (modules '((gnu build shepherd)
+              (gnu system file-systems)))
+   (start
+    (with-imported-modules (source-module-closure '((gnu build shepherd)
+                                                    (gnu system file-systems)))
+      #~(make-forkexec-constructor/container
+         (list #$(development-server-configuration-executable-path config)
+               "127.0.0.1" #$(number->string (development-server-configuration-port config)))
+         #:mappings (list (file-system-mapping
+                           (source #$(development-server-configuration-executable-path config))
+                           (target source)))
+         #:log-file "/var/log/genenetwork3.log")))
+   (stop #~(make-kill-destructor))))
+
+(define %default-genenetwork3-configuration
+  (development-server-configuration
+   (name "genenetwork3")
+   (git-repository "https://github.com/genenetwork/genenetwork3")
+   (git-branch "main")
+   (executable-path "/laminar/bin/genenetwork3")
+   (runner (with-imported-modules (source-module-closure '((genenetwork development-helper))
+                                                         #:select? import-module?)
+             #~(lambda (latest-gn3-source)
+                 ((@@ (genenetwork development-helper) genenetwork3-runner-gexp)
+                  latest-gn3-source
+                  #$(profile
+                     (content (manifest-cons gunicorn
+                                             (package->development-manifest genenetwork3)))
+                     (allow-collisions? #t))))))))
+
+(define genenetwork3-service-type
+  (service-type
+   (name 'genenetwork3)
+   (description "Run GeneNetwork 3.")
+   (extensions
+    (list (service-extension activation-service-type
+                             development-server-activation)
+          (service-extension shepherd-root-service-type
+                             (compose list genenetwork3-shepherd-service))
+          (service-extension forge-service-type
+                             (compose list genenetwork3-project))))
+   (default-value %default-genenetwork3-configuration)))
+
+
+;;;
+;;; qc
+;;; 
+
+(define qc-tests
+  (with-imported-modules (cons '(guix build lisp-utils)
+                               (source-module-closure '((genenetwork development-helper))
+                                                      #:select? import-module?))
+    #~(lambda (source)
+        ((@@ (genenetwork development-helper)
+             asdf-test-gexp)
+         source
+         #$(profile
+            (content (package->development-manifest sbcl-qc))
+            (allow-collisions? #t))
+         "qc" (list "qc.asd")))))
+
+(define qc-project
+  (forge-project
+   (name "qc")
+   (repository "https://git.genenetwork.org/jgart/qc")
+   (ci-jobs (list (forge-laminar-job
+                   (name "qc")
+                   (run (derivation-job-gexp
+                         this-forge-project
+                         this-forge-laminar-job
+                         qc-tests
+                         #:guix-daemon-uri %guix-daemon-uri)))))
+   (ci-jobs-trigger 'webhook)))
+
+
+;;;
+;;; dump-genenetwork-database
+;;; 
+
+;; Unreleased version of ccwl that is required by
+;; dump-genenetwork-database for its graphql library.
+(define ccwl
+  (let ((commit "02677a508b407779f5991a230341e016deb7f69b")
+        (revision "0"))
+    (package
+      (inherit guix:ccwl)
+      (name "ccwl")
+      (version (git-version (package-version guix:ccwl) revision commit))
+      (source
+       (origin
+         (method git-fetch)
+         (uri (git-reference
+               (url "https://github.com/arunisaac/ccwl")
+               (commit commit)))
+         (file-name (git-file-name name version))
+         (sha256
+          (base32
+           "1kxry8y0pibl0x789jrzqkkh2s59ajyinfvrgvd00gkbqldih82r")))))))
+
+;; guile-sparql tests are broken. Disable them temporarily. The issue
+;; has been reported upstream at
+;; https://github.com/roelj/guile-sparql/issues/6
+(define guile-sparql
+  (package
+    (inherit guix:guile-sparql)
+    (arguments
+     `(#:tests? #f))))
+
+;; Temporarily package run64 here until it can be contributed to
+;; upstream Guix.
+(define run64
+  (package
+    (name "run64")
+    (version "0.1.0")
+    (source (origin
+              (method git-fetch)
+              (uri (git-reference
+                    (url "https://git.systemreboot.net/run64")
+                    (commit "a271723e3938b158aa6748e8befceb114b84c6df")))
+              (file-name (git-file-name name version))
+              (sha256
+               (base32
+                "1kdx8h2x5a4cp8azzy1v2xgyb2153sakb1wbi2rj5ygkpmasygbm"))))
+    (build-system gnu-build-system)
+    (arguments
+     `(#:make-flags (list (string-append "prefix=" %output))
+       #:phases
+       (modify-phases %standard-phases
+         (delete 'configure))))
+    (home-page "https://run64.systemreboot.net")
+    (synopsis "SRFI-64 test runner for Scheme")
+    (description "run64 is a SRFI-64 test runner for Scheme.")
+    (license license:gpl3+)))
+
+(define dump-genenetwork-database-tests
+  (with-imported-modules (source-module-closure '((genenetwork development-helper))
+                                                #:select? import-module?)
+    #~(lambda (source)
+        ((@@ (genenetwork development-helper)
+             command-in-source-gexp)
+         source
+         #$(profile
+            (content (packages->manifest
+                      (list gnu-make guile-3.0 guile-dbi guile-dbd-mysql
+                            ccwl graphviz guile-libyaml guile-sparql run64)))
+            (allow-collisions? #t))
+         (list "make" "check")))))
+
+(define dump-genenetwork-database-project
+  (forge-project
+   (name "dump-genenetwork-database")
+   (repository "https://git.genenetwork.org/arunisaac/dump-genenetwork-database")
+   (ci-jobs (list (forge-laminar-job
+                   (name "dump-genenetwork-database")
+                   (run (derivation-job-gexp
+                         this-forge-project
+                         this-forge-laminar-job
+                         dump-genenetwork-database-tests
+                         #:guix-daemon-uri %guix-daemon-uri)))))
+   (ci-jobs-trigger 'webhook)))
+
+
+;;;
+;;; gn-gemtext-threads
+;;;
+
+(define (gn-gemtext-threads-website project job)
+  (with-imported-modules '((guix utils))
+    #~(begin
+        (use-modules (guix utils))
+      
+        (switch-symlinks #$(forge-project-website-directory project)
+                         #$(derivation-job-gexp
+                            project
+                            job
+                            (with-imported-modules (source-module-closure '((genenetwork development-helper))
+                                                                          #:select? import-module?)
+                              #~(lambda (source-checkout)
+                                  ((@@ (genenetwork development-helper)
+                                       tissue-website-gexp)
+                                   source-checkout
+                                   #$(profile
+                                      (content (packages->manifest (list tissue)))
+                                      (allow-collisions? #t)))))
+                            #:guix-daemon-uri %guix-daemon-uri
+                            #:deep-clone? #t)))))
+
+(define gn-gemtext-threads-project
+  (forge-project
+   (name "gn-gemtext-threads")
+   (repository "https://github.com/genenetwork/gn-gemtext-threads/")
+   (website-directory "/srv/http/issues")
+   (ci-jobs (list (forge-laminar-job
+                   (name "gn-gemtext-threads")
+                   (run (gn-gemtext-threads-website
+                         this-forge-project
+                         this-forge-laminar-job)))))
+   ;; TODO: Also rebuild every night to handle update of stale issues.
+   (ci-jobs-trigger 'webhook)))
+
+
+;;;
+;;; operating-system definition
+;;;
+
+(operating-system
+  (host-name "genenetwork-development")
+  (timezone "UTC")
+  (locale "en_US.utf8")
+  (bootloader (bootloader-configuration
+               (bootloader grub-bootloader)
+               (targets (list "/dev/sdX"))))
+  (file-systems (cons (file-system
+                        (device "root")
+                        (mount-point "/")
+                        (type "ext4"))
+                      %base-file-systems))
+  (users %base-user-accounts)
+  (packages %base-packages)
+  (sudoers-file
+   (mixed-text-file "sudoers"
+                    "@include " %sudoers-specification
+                    ;; Permit the laminar user to restart genenetwork2
+                    ;; and genenetwork3.
+                    "\nlaminar ALL = NOPASSWD: "
+                    (file-append shepherd "/bin/herd") " restart genenetwork2, "
+                    (file-append shepherd "/bin/herd") " restart genenetwork3\n"))
+  (services (cons* (service forge-service-type
+                            (forge-configuration
+                             (projects (list qc-project
+                                             dump-genenetwork-database-project
+                                             gn-gemtext-threads-project))))
+                   (service laminar-service-type
+                            (laminar-configuration
+                             (bind-http "localhost:9090")))
+                   (service webhook-service-type
+                            (webhook-configuration
+                             (port 9091)))
+                   (service redis-service-type)
+                   (service virtuoso-service-type
+                            (virtuoso-configuration
+                             (server-port 8891)
+                             (http-server-port 8892)))
+                   (service genenetwork2-service-type
+                            (development-server-configuration
+                             (inherit %default-genenetwork2-configuration)
+                             (port 9092)))
+                   (service genenetwork3-service-type
+                            (development-server-configuration
+                             (inherit %default-genenetwork3-configuration)
+                             (port %genenetwork3-port)))
+                   %base-services)))
diff --git a/genenetwork/development-helper.scm b/genenetwork/development-helper.scm
new file mode 100644
index 0000000..e8364ef
--- /dev/null
+++ b/genenetwork/development-helper.scm
@@ -0,0 +1,159 @@
+;;; genenetwork-machines --- Guix configuration for genenetwork machines
+;;; Copyright © 2022 Arun Isaac <arunisaac@systemreboot.net>
+;;;
+;;; This file is part of genenetwork-machines.
+;;;
+;;; genenetwork-machines is free software: you can redistribute it
+;;; and/or modify it under the terms of the GNU General Public License
+;;; as published by the Free Software Foundation, either version 3 of
+;;; the License, or (at your option) any later version.
+;;;
+;;; genenetwork-machines is distributed in the hope that it will be
+;;; useful, but WITHOUT ANY WARRANTY; without even the implied
+;;; warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.
+;;; See the GNU General Public License for more details.
+;;;
+;;; You should have received a copy of the GNU General Public License
+;;; along with genenetwork-machines.  If not, see
+;;; <https://www.gnu.org/licenses/>.
+
+(define-module (genenetwork development-helper)
+  #:use-module (ice-9 match)
+  #:use-module (guix gexp)
+  #:use-module (guix profiles)
+  #:use-module (guix search-paths)
+  #:use-module (forge build utils))
+
+(define (command-in-source-gexp source profile command)
+  "Return a G-expression that runs COMMAND in PROFILE and with SOURCE
+as the current directory. SOURCE and PROFILE are store items. COMMAND
+is a list of strings specifying the command to be executed."
+  (with-imported-modules '((guix build utils))
+    (with-profile profile
+      #~(begin
+          (use-modules (rnrs exceptions)
+                       (guix build utils))
+
+          (chdir #$source)
+          (guard (condition ((invoke-error? condition)
+                             (format (current-error-port)
+                                     "`~a~{ ~a~}' failed with exit status ~a~%"
+                                     (invoke-error-program condition)
+                                     (invoke-error-arguments condition)
+                                     (invoke-error-exit-status condition))
+                             (exit #f)))
+            (apply invoke '#$command))
+          (mkdir-p #$output)))))
+
+(define (asdf-test-gexp source profile system asd-files)
+  "Return a G-expression that tests SYSTEM using asdf after loading
+ASD-FILES. SOURCE is the source code under test. PROFILE is a profile
+with all necessary dependencies. SOURCE and PROFILE are both store
+items."
+  (with-imported-modules '((guix build lisp-utils)
+                           (guix build utils))
+    (with-profile profile
+      #~(begin
+          (use-modules (guix build lisp-utils)
+                       (guix build utils))
+
+          (chdir #$source)
+          (setenv "HOME" "/tmp")
+          (parameterize ((%lisp "sbcl")
+                         (%lisp-type "sbcl"))
+            (test-system #$system '#$asd-files #f))
+          (mkdir-p #$output)))))
+
+(define (genenetwork3-lint-gexp genenetwork3-source profile)
+  "Return a G-expression that runs GeneNetwork3 lint tests in PROFILE
+with GENENETWORK3-SOURCE as the current directory. GENENETWORK3-SOURCE
+is a checkout of the genenetwork3 source code. PROFILE is a profile
+with genenetwork3 dependencies."
+  (with-imported-modules '((guix build utils))
+    (with-profile profile
+      #~(begin
+          (use-modules (rnrs exceptions)
+                       (srfi srfi-26)
+                       (ice-9 rdelim)
+                       (guix build utils))
+
+          (define (shell-script? filename stat-obj)
+            (and (eq? (stat:type stat-obj) 'regular)
+                 (call-with-input-file filename
+                   (lambda (port)
+                     (let ((first-line (read-line port)))
+                       (and (not (eof-object? first-line))
+                            (> (string-length first-line) 2)
+                            (string=? (string-take first-line 2) "#!")
+                            (or (string-contains first-line "/bin/sh")
+                                (string-contains first-line "/bin/bash"))))))))
+          
+          (chdir #$genenetwork3-source)
+          (guard (condition ((invoke-error? condition)
+                             (format (current-error-port)
+                                     "`~a~{ ~a~}' failed with exit status ~a~%"
+                                     (invoke-error-program condition)
+                                     (invoke-error-arguments condition)
+                                     (invoke-error-exit-status condition))
+                             (exit #f)))
+            (for-each (cut invoke "shellcheck" <>)
+                      (find-files "." shell-script?))
+            (invoke "pylint" "gn3"))
+          (mkdir-p #$output)))))
+
+(define (genenetwork2-runner-gexp genenetwork2-source profile gn3-port genotype-files)
+  "Return a G-expression that runs the genenetwork2 server for
+GENENETWORK2-SOURCE in PROFILE. GENENETWORK2-SOURCE is a checkout of
+the genenetwork2 source code. PROFILE is a profile with genenetwork2
+dependencies. GN3-PORT is the port on which a local instance of
+genenetwork3 is listening. GENOTYPE-FILES is the path to genotype
+files."
+  (with-imported-modules '((guix build utils))
+    (with-profile profile
+      #~(begin
+          (use-modules (guix build utils)
+                       (ice-9 match))
+          
+          (chdir #$genenetwork2-source)
+          (match (command-line)
+            ((_ ip port)
+             (setenv "SERVER_PORT" port)
+             (setenv "GN2_PROFILE" #$profile)
+             (setenv "GN_PROXY_URL" "http://genenetwork.org/gn3-proxy")
+             (setenv "GN3_LOCAL_URL"
+                     (string-append "http://localhost:"
+                                    (number->string #$gn3-port)))
+             (setenv "GENENETWORK_FILES" #$genotype-files)
+             (setenv "SQL_URI" "mysql://webqtlout:webqtlout@localhost/db_webqtl")
+             (setenv "HOME" "/tmp")
+             (setenv "NO_REDIS" "no-redis")
+             (invoke "sh" "bin/genenetwork2")))))))
+
+(define (genenetwork3-runner-gexp genenetwork3-source profile)
+  "Return a G-expression that runs the genenetwork3 server for
+GENENETWORK3-SOURCE in PROFILE. GENENETWORK3-SOURCE is a checkout of
+the genenetwork3 source code. PROFILE is a profile with genenetwork3
+dependencies."
+  (with-imported-modules '((guix build utils))
+    (with-profile profile
+      #~(begin
+          (use-modules (guix build utils)
+                       (ice-9 match))
+          
+          (chdir #$genenetwork3-source)
+          (match (command-line)
+            ((_ ip port)
+             (invoke "gunicorn"
+                     "-b" (string-append ip ":" port)
+                     "gn3.app:create_app()")))))))
+
+(define (tissue-website-gexp source profile)
+  "Return a G-expression that builds a tissue website from
+SOURCE. PROFILE is a profile with necessary dependencies."
+  (with-imported-modules '((guix build utils))
+    (with-profile profile
+      #~(begin
+          (use-modules (guix build utils))
+
+          (chdir #$source)
+          (invoke "tissue" "web" #$output)))))