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Diffstat (limited to 'topics')
| -rw-r--r-- | topics/quality-control/qc-checks.gmi | 13 |
1 files changed, 13 insertions, 0 deletions
diff --git a/topics/quality-control/qc-checks.gmi b/topics/quality-control/qc-checks.gmi index 30236e1..713fa0b 100644 --- a/topics/quality-control/qc-checks.gmi +++ b/topics/quality-control/qc-checks.gmi @@ -58,3 +58,16 @@ phenotypes. -- Rob ``` + +``` +QTL analysis was performed in F2 mice using the R package R/qtl +(RRID:SCR_009085) as previously described.11,29,42 Quality checking +of genotypes and QTL analysis were performed in R (https://www.r- +project.org/) using R/bestNormalize (https://github.com/petersonR/ +bestNormalize) and R/qtl.42 Phenotypes were assessed for normality +using the Shapiro–Wilk Test. Because some of the data residuals devi- +ated significantly from normality, we used the orderNorm function to +perform Ordered Quantile normalization43 on all phenotypes. QTL +-- +A quantitative trait variant in Gabra2 underlies increased methamphetamine stimulant sensitivity +``` |