summaryrefslogtreecommitdiff
path: root/topics/features/genenetwork
diff options
context:
space:
mode:
Diffstat (limited to 'topics/features/genenetwork')
-rw-r--r--topics/features/genenetwork/search.gmi4
1 files changed, 4 insertions, 0 deletions
diff --git a/topics/features/genenetwork/search.gmi b/topics/features/genenetwork/search.gmi
index 71718fa..003a887 100644
--- a/topics/features/genenetwork/search.gmi
+++ b/topics/features/genenetwork/search.gmi
@@ -18,6 +18,10 @@ brca - only renders 2 results, why not BRCA2?
Keywords like tissue appear to be case sensitive. Should not be the case.
+In the paper `New Insights on Gene by Environmental Effects of Drugs of Abuse in Animal Models Using GeneNetwork' the authors reanalyzed an older experimental data in the GeneNetwork database.
+They discovered QTLs on mouse chromosomes 3, 5, 9, 11, and 14, not found in the original study
+and found new candidate genes included Slitrk6 and Cdk14. Slitrk6, in a Chromosome14 QTL for locomotion, was found to be part of a co-expression network involved in voluntary movement and associated with neuropsychiatric phenotypes. Cdk14, one of only three genes in a Chromosome5 QTL, is associated with handling induced convulsions after ethanol treatment, that is regulated by the anticonvulsant drug valproic acid\cite{PMC9024903}.
+
## Future
* Add human SNP search and synteny