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diff --git a/issues/mgamma/mgamma-design.gmi b/issues/mgamma/mgamma-design.gmi new file mode 100644 index 0000000..23e02d5 --- /dev/null +++ b/issues/mgamma/mgamma-design.gmi @@ -0,0 +1,9 @@ +# MGAMMA design philosophy + +We have a lot of experience running and hacking the GEMMA tool in GeneNetwork.org: + +=> https://github.com/genetics-statistics/GEMMA + +GEMMA proves to give great GWA results and has a decent speed for a single threaded implementation - even though the matrix calls to openblas use multiple threads. The source code base of GEMMA, however, proves hard to build on. This is why we are creating a next generation tool that has a focus on *performance and hackability*. + +After several attempts using R, D, Julia, python, Ruby we have in 2023 settled on Guile+C+Zig. Guile provides a REPL and great hackabability. C+Zig we'll use for performance. The other languages are all great, but we think we can work faster in this setup. |