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| -rw-r--r-- | issues/gemma/HS-Rat-crashes-gemma.gmi | 30 |
1 files changed, 29 insertions, 1 deletions
diff --git a/issues/gemma/HS-Rat-crashes-gemma.gmi b/issues/gemma/HS-Rat-crashes-gemma.gmi index be0af66..6d8f5c8 100644 --- a/issues/gemma/HS-Rat-crashes-gemma.gmi +++ b/issues/gemma/HS-Rat-crashes-gemma.gmi @@ -61,10 +61,38 @@ The geno file is massive: 3.4M Mar 12 11:56 HSNIH-Palmer_true_snps.txt ``` -Probably best to test on a different machine! Let's move to tux02. Running luna (a half year old version of GN2) gives `**** FAILED: number of columns in the kinship file does not match the number of individuals for row = 79`. So, that does not help! I think this is a known issue that got fixed later. Next up, try and run gemma by hand for chromosome 1 after installing gemma tools with a recent GNU Guix: +Probably best to test on a different machine! Let's move to tux02. Running luna (a half year old version of GN2) gives `**** FAILED: number of columns in the kinship file does not match the number of individuals for row = 79`. So, that does not help! I think this is a known issue that got fixed later. Next up, try and run gemma by hand for (largest) chromosome 1 after installing gemma tools with a recent GNU Guix: ``` +tux02:~/tmp/gemma-cpu-lockup$ /usr/bin/time -v gemma -loco 1 -gk -g HSNIH-Palmer_true_geno.txt -p PHENO_2+FcfQiTVSC7FmmbsatUPg.txt -a HSNIH-Palmer_true_snps.txt + +GEMMA 0.98.5-pre1 (2021-08-14) by Xiang Zhou, Pjotr Prins and team (C) 2012-2021 +Reading Files ... +## number of total individuals = 6147 +## number of analyzed individuals = 1306 +## number of covariates = 1 +## number of phenotypes = 1 +## leave one chromosome out (LOCO) = 1 +## number of total SNPs/var = 134918 +## number of SNPS for K = 121094 +## number of SNPS for GWAS = 13824 +## number of analyzed SNPs = 132628 +Calculating Relatedness Matrix ... +**** INFO: Done. + Command being timed: "gemma -loco 1 -gk -g HSNIH-Palmer_true_geno.txt -p PHENO_2+FcfQiTVSC7FmmbsatUPg.txt -a HSNIH-Palmer_true_snps.txt" + User time (seconds): 3096.83 + System time (seconds): 1435.51 + Percent of CPU this job got: 1781% + Elapsed (wall clock) time (h:mm:ss or m:ss): 4:14.36 + Maximum resident set size (kbytes): 26851444 +``` + +That is 4 minutes wall clock time using about 26GB of RAM. The machine has 256 GB RAM, so you can see where the problem is. Gemma-wrapper should handle this gracefully, but because of overcommit the machine goes in a tail-spin. +Next run lmm with + +``` +/usr/bin/time -v gemma -loco 1 -lmm 9 -g HSNIH-Palmer_true_geno.txt -p PHENO_2+FcfQiTVSC7FmmbsatUPg.txt -a HSNIH-Palmer_true_snps.txt -k output/result.cXX.txt ``` Now the goal is to try and crash the server before setting overcommit. |