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| author | Pjotr Prins | 2022-11-01 13:38:30 +0100 |
|---|---|---|
| committer | Pjotr Prins | 2022-11-01 13:38:30 +0100 |
| commit | 007264d03484ed62a06c6bc5747881c409250561 (patch) | |
| tree | 3336320c2e411624aaeaccf0bf112bab2dfa21a6 /topics/features | |
| parent | c74e08e8c99dc7fbd84333693ee79fc1aba3db6d (diff) | |
| download | gn-gemtext-007264d03484ed62a06c6bc5747881c409250561.tar.gz | |
search: add Ashbrook paper
Diffstat (limited to 'topics/features')
| -rw-r--r-- | topics/features/genenetwork/search.gmi | 4 |
1 files changed, 4 insertions, 0 deletions
diff --git a/topics/features/genenetwork/search.gmi b/topics/features/genenetwork/search.gmi index 71718fa..003a887 100644 --- a/topics/features/genenetwork/search.gmi +++ b/topics/features/genenetwork/search.gmi @@ -18,6 +18,10 @@ brca - only renders 2 results, why not BRCA2? Keywords like tissue appear to be case sensitive. Should not be the case. +In the paper `New Insights on Gene by Environmental Effects of Drugs of Abuse in Animal Models Using GeneNetwork' the authors reanalyzed an older experimental data in the GeneNetwork database. +They discovered QTLs on mouse chromosomes 3, 5, 9, 11, and 14, not found in the original study +and found new candidate genes included Slitrk6 and Cdk14. Slitrk6, in a Chromosome14 QTL for locomotion, was found to be part of a co-expression network involved in voluntary movement and associated with neuropsychiatric phenotypes. Cdk14, one of only three genes in a Chromosome5 QTL, is associated with handling induced convulsions after ethanol treatment, that is regulated by the anticonvulsant drug valproic acid\cite{PMC9024903}. + ## Future * Add human SNP search and synteny |