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authorPjotr Prins2022-12-05 08:55:37 -0600
committerPjotr Prins2022-12-05 08:55:37 -0600
commitab419a9e1354934a0d1d316154d43d1fa85ae468 (patch)
treeb9ead99d177b2c597dd7e45c9b03f6b43a099d7b
parent8711e04939fb102eb2f4093000f2382cfb547858 (diff)
downloadgn-gemtext-ab419a9e1354934a0d1d316154d43d1fa85ae468.tar.gz
Moving features to gn-doc repo
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-# Search
-
-## Overview
-
-One of the key features of GN is the powerful search functionality. For most users it is the entry point for using the GeneNetwork web service. On the front-page a menu is offered that allows selecting species, e.g. mouse or rat, and relevant datasets grouped by family, e.g. BXD, and type, e.g. Hippocampus mRNA.
-Recently we introduced the Xapian search engine that allows for fast lookups and powerful search queries.
-A example search for the BRCA2 results in GN searching for the term "BRCA2" in 754 datasets and 39,765,944 traits across 10 species and found 7998 results that match the query.
-The search URL looks like 'https://genenetwork.org/gsearch?type=gene&terms=BRCA2' and can be copy-pasted and shared with other users.
-
-More powerful queries will narrow down on field in the result table. For example to get only mouse results "species:mouse BRCA2" found 5916 results.
-
-Example search terms:
-
-```
-species:mouse BRCA2 - looks good, has Liver
-species:mouse Tissue:Liver - 0 results
-species:mouse tissue:Liver - 0 results
-brca - only renders 2 results, why not BRCA2?
-```
-
-Keywords like tissue appear to be case sensitive. Should not be the case.
-
-GeneNetwork search functionality is used in the publication `Integrative Functional Genomics for Systems Genetics in GeneWeaver.org`. The authors present their webservice by searching for a "nociception" QTL in a region on chromosome 4 found in GN. They export the details and use it for further analysis in GeneWeaver\cite{bubier2016}.
-
-In the publication `Systems Genetics of Obesity` GeneNetwork search is used to find genes contributing to collagen content in adipose tissue in the BXD and find similar cis-eQTL connected with adipose tissue that exist in other studies hosted on GN\cite{brockmann2016}.
-
-In the paper `New Insights on Gene by Environmental Effects of Drugs of Abuse in Animal Models Using GeneNetwork' the authors reanalyzed an older experimental data in the GeneNetwork database.
-They discovered QTLs on mouse chromosomes 3, 5, 9, 11, and 14, not found in the original study
-and found new candidate genes included Slitrk6 and Cdk14. Slitrk6, in a Chromosome14 QTL for locomotion, was found to be part of a co-expression network involved in voluntary movement and associated with neuropsychiatric phenotypes. Cdk14, one of only three genes in a Chromosome5 QTL, is associated with handling induced convulsions after ethanol treatment, that is regulated by the anticonvulsant drug valproic acid\cite{PMC9024903}.
-
-## Future
-
-* Add human SNP search and synteny
-* Support more sources, e.g. geneweaver
-
-## Methods
-
-GN search is built on
-Xapian, an Open Source Search Engine Library, released under the GPL v2+. It's written in C++, with bindings to allow use from Python, Guile and other languages.
-Xapian is actively maintained and current Xapian users include, for example, the Debian website and the notmuch E-mail indexer.
-Xapian is a highly adaptable toolkit which allows developers to easily add advanced indexing and search facilities to their own applications. It has built-in support for several families of weighting models and also supports a rich set of boolean query operators\cite{Xapian}.
-We build the Xapian index from SQL data and RDF data in the GN databases.
-
-=> topics/xapian-indexing.gmi indexing optimizations