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authorPjotr Prins2022-11-01 13:38:30 +0100
committerPjotr Prins2022-11-01 13:38:30 +0100
commit007264d03484ed62a06c6bc5747881c409250561 (patch)
tree3336320c2e411624aaeaccf0bf112bab2dfa21a6
parentc74e08e8c99dc7fbd84333693ee79fc1aba3db6d (diff)
downloadgn-gemtext-007264d03484ed62a06c6bc5747881c409250561.tar.gz
search: add Ashbrook paper
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@@ -18,6 +18,10 @@ brca - only renders 2 results, why not BRCA2?
Keywords like tissue appear to be case sensitive. Should not be the case.
+In the paper `New Insights on Gene by Environmental Effects of Drugs of Abuse in Animal Models Using GeneNetwork' the authors reanalyzed an older experimental data in the GeneNetwork database.
+They discovered QTLs on mouse chromosomes 3, 5, 9, 11, and 14, not found in the original study
+and found new candidate genes included Slitrk6 and Cdk14. Slitrk6, in a Chromosome14 QTL for locomotion, was found to be part of a co-expression network involved in voluntary movement and associated with neuropsychiatric phenotypes. Cdk14, one of only three genes in a Chromosome5 QTL, is associated with handling induced convulsions after ethanol treatment, that is regulated by the anticonvulsant drug valproic acid\cite{PMC9024903}.
+
## Future
* Add human SNP search and synteny