path: root/general/datasets/Ohsu_hs_cc_ilmstr_0211/summary.rtf

<blockquote>The current study focused on the extent genetic diversity within a species (Mus musculus) affects gene co-expression network structure. To examine this issue, we have created a new mouse resource, a heterogeneous stock (HS) formed from the same eight inbred strains that have been used to create the collaborative cross (CC). The eight inbred strains capture &gt; 90% of the genetic diversity available within the species. For contrast with the HS-CC, a C57BL/6J (B6) &times; DBA/2J (D2) F2 intercross and the HS4, derived from crossing the B6, D2, BALB/cJ and LP/J strains, were used. Brain (striatum) gene expression data were obtained using the Illumina Mouse WG 6.1 array, and the data sets were interrogated using a weighted gene co-expression network analysis (WGCNA).<br />
Read full article: <a href="GN304_Iancu_Hitzemann.pdf" target="_blank">Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouse</a>.</blockquote>