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-<p>We would like to thank Cristina Cartoni, S&eacute;bastien Lamy, and Charles Thomas at the Center of Phenogenomics (CPG, EPFL) for help in establishing and phenotyping the BXD mice. We thank the Molecular Resource Center of Excellence at The University of Tennessee Health Science Center processing all microarrays.&nbsp;The work in the Auwerx lab was supported by the Ecole Polytechnique Federale de Lausanne, the EU Ideas program (AdG-23138 and AdG-322424), the NIH (R01HL106511-01A and R01AG043930), and the Swiss National Science Foundation (31003A- 124713 and 31003A-125487 and CSRII3-1362).</p>