aboutsummaryrefslogtreecommitdiff
path: root/general/datasets/Hzi_0408_m
diff options
context:
space:
mode:
authorBonface2024-02-13 23:52:26 -0600
committerMunyoki Kilyungi2024-08-09 13:30:43 +0300
commitb2feda451ccfbeaed02dce9088d6dd228cf15861 (patch)
tree3dd2883524985114070a7770cd2e9f9bd7eb1848 /general/datasets/Hzi_0408_m
parentd029d5d7f8ead1f1de8d318045004a4a6f68f5fb (diff)
downloadgn-docs-b2feda451ccfbeaed02dce9088d6dd228cf15861.tar.gz
Update dataset RTF Files.
Diffstat (limited to 'general/datasets/Hzi_0408_m')
-rw-r--r--general/datasets/Hzi_0408_m/cases.rtf784
-rw-r--r--general/datasets/Hzi_0408_m/summary.rtf37
2 files changed, 821 insertions, 0 deletions
diff --git a/general/datasets/Hzi_0408_m/cases.rtf b/general/datasets/Hzi_0408_m/cases.rtf
new file mode 100644
index 0000000..83b146d
--- /dev/null
+++ b/general/datasets/Hzi_0408_m/cases.rtf
@@ -0,0 +1,784 @@
+<blockquote>
+<table border="1" cellpadding="0" cellspacing="0" style="width:600px">
+ <tbody>
+ <tr>
+ <td>
+ <table align="left" border="1" cellpadding="5" cellspacing="1" class="sortable" style="width:600px">
+ <tbody>
+ <tr>
+ <td>Index</td>
+ <td>Array</td>
+ <td>Sample</td>
+ <td>Strain</td>
+ <td>Sex</td>
+ <td>Age</td>
+ <td>Color</td>
+ <td>Pool Size</td>
+ <td>Source</td>
+ </tr>
+ <tr>
+ <td>1</td>
+ <td>R4435LU.CEL</td>
+ <td>R4435LU</td>
+ <td>BXD100</td>
+ <td>F</td>
+ <td>64</td>
+ <td>black</td>
+ <td>2</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>2</td>
+ <td>R4436LU.CEL</td>
+ <td>R4436LU</td>
+ <td>BXD14</td>
+ <td>F</td>
+ <td>85</td>
+ <td>black</td>
+ <td>2</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>3</td>
+ <td>R4437LU.CEL</td>
+ <td>R4437LU</td>
+ <td>BXD34</td>
+ <td>F</td>
+ <td>58</td>
+ <td>black</td>
+ <td>5</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>4</td>
+ <td>R4438LU.CEL</td>
+ <td>R4438LU</td>
+ <td>BXD39</td>
+ <td>F</td>
+ <td>63</td>
+ <td>gray</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>5</td>
+ <td>R4439LU.CEL</td>
+ <td>R4439LU</td>
+ <td>BXD40</td>
+ <td>F</td>
+ <td>54</td>
+ <td>gray</td>
+ <td>3</td>
+ <td>ORNL</td>
+ </tr>
+ <tr>
+ <td>6</td>
+ <td>R4440LU.CEL</td>
+ <td>R4440LU</td>
+ <td>BXD45</td>
+ <td>F</td>
+ <td>60</td>
+ <td>dilute brown DBA</td>
+ <td>4</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>7</td>
+ <td>R4441LU.CEL</td>
+ <td>R4441LU</td>
+ <td>BXD50</td>
+ <td>F</td>
+ <td>64</td>
+ <td>dilute brown DBA</td>
+ <td>4</td>
+ <td>ORNL</td>
+ </tr>
+ <tr>
+ <td>8</td>
+ <td>R4442LU.CEL</td>
+ <td>R4442LU</td>
+ <td>BXD1</td>
+ <td>F</td>
+ <td>88</td>
+ <td>dilute brown DBA</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>9</td>
+ <td>R4443LU.CEL</td>
+ <td>R4443LU</td>
+ <td>BXD16</td>
+ <td>F</td>
+ <td>79</td>
+ <td>gray</td>
+ <td>3</td>
+ <td>ORNL</td>
+ </tr>
+ <tr>
+ <td>10</td>
+ <td>R4444LU.CEL</td>
+ <td>R4444LU</td>
+ <td>BXD12</td>
+ <td>F</td>
+ <td>61</td>
+ <td>gray</td>
+ <td>5</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>11</td>
+ <td>R4445LU.CEL</td>
+ <td>R4445LU</td>
+ <td>BXD21</td>
+ <td>F</td>
+ <td>50</td>
+ <td>dilute brown DBA</td>
+ <td>3</td>
+ <td>ORNL</td>
+ </tr>
+ <tr>
+ <td>12</td>
+ <td>R4446LU.CEL</td>
+ <td>R4446LU</td>
+ <td>BXD19</td>
+ <td>F</td>
+ <td>49</td>
+ <td>gray</td>
+ <td>3</td>
+ <td>ORNL</td>
+ </tr>
+ <tr>
+ <td>13</td>
+ <td>R4447LU.CEL</td>
+ <td>R4447LU</td>
+ <td>BXD27</td>
+ <td>F</td>
+ <td>85</td>
+ <td>brown</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>14</td>
+ <td>R4448LU.CEL</td>
+ <td>R4448LU</td>
+ <td>BXD31</td>
+ <td>F</td>
+ <td>81</td>
+ <td>black</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>15</td>
+ <td>R4449LU.CEL</td>
+ <td>R4449LU</td>
+ <td>BXD32</td>
+ <td>F</td>
+ <td>68</td>
+ <td>black</td>
+ <td>5</td>
+ <td>ORNL</td>
+ </tr>
+ <tr>
+ <td>16</td>
+ <td>R4450LU.CEL</td>
+ <td>R4450LU</td>
+ <td>BXD33</td>
+ <td>F</td>
+ <td>61</td>
+ <td>gray</td>
+ <td>2</td>
+ <td>ORNL</td>
+ </tr>
+ <tr>
+ <td>17</td>
+ <td>R4451LU.CEL</td>
+ <td>R4451LU</td>
+ <td>BXD42</td>
+ <td>F</td>
+ <td>65</td>
+ <td>black</td>
+ <td>2</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>18</td>
+ <td>R4452LU.CEL</td>
+ <td>R4452LU</td>
+ <td>BXD43</td>
+ <td>F</td>
+ <td>79</td>
+ <td>black</td>
+ <td>2</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>19</td>
+ <td>R4453LU.CEL</td>
+ <td>R4453LU</td>
+ <td>BXD45</td>
+ <td>F</td>
+ <td>60</td>
+ <td>dilute brown DBA</td>
+ <td>4</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>20</td>
+ <td>R4454LU.CEL</td>
+ <td>R4454LU</td>
+ <td>BXD55</td>
+ <td>M</td>
+ <td>80</td>
+ <td>brown</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>21</td>
+ <td>R4455LU.CEL</td>
+ <td>R4455LU</td>
+ <td>BXD56</td>
+ <td>M</td>
+ <td>91</td>
+ <td>black</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>22</td>
+ <td>R4456LU.CEL</td>
+ <td>R4456LU</td>
+ <td>BXD66</td>
+ <td>F</td>
+ <td>80</td>
+ <td>brown</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>23</td>
+ <td>R4457LU.CEL</td>
+ <td>R4457LU</td>
+ <td>BXD68</td>
+ <td>F</td>
+ <td>65</td>
+ <td>brown</td>
+ <td>4</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>24</td>
+ <td>R4459LU-re.CEL</td>
+ <td>R4459LU</td>
+ <td>BXD89</td>
+ <td>F</td>
+ <td>79</td>
+ <td>dilute brown DBA</td>
+ <td>2</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>25</td>
+ <td>R4460LU.CEL</td>
+ <td>R4460LU</td>
+ <td>BXD51</td>
+ <td>M</td>
+ <td>81</td>
+ <td>black</td>
+ <td>2</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>26</td>
+ <td>R4461LU.CEL</td>
+ <td>R4461LU</td>
+ <td>BXD97</td>
+ <td>F</td>
+ <td>N/A</td>
+ <td>N/A</td>
+ <td>N/A</td>
+ <td>N/A</td>
+ </tr>
+ <tr>
+ <td>27</td>
+ <td>R4462LU.CEL</td>
+ <td>R4462LU</td>
+ <td>BXD48</td>
+ <td>F</td>
+ <td>61</td>
+ <td>black</td>
+ <td>3</td>
+ <td>ORNL</td>
+ </tr>
+ <tr>
+ <td>28</td>
+ <td>R4463LU.CEL</td>
+ <td>R4463LU</td>
+ <td>BXD60</td>
+ <td>M</td>
+ <td>93</td>
+ <td>brown</td>
+ <td>2</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>29</td>
+ <td>R4464LU.CEL</td>
+ <td>R4464LU</td>
+ <td>BXD62</td>
+ <td>M</td>
+ <td>80</td>
+ <td>brown</td>
+ <td>2</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>30</td>
+ <td>R4465LU.CEL</td>
+ <td>R4465LU</td>
+ <td>BXD69</td>
+ <td>M</td>
+ <td>63</td>
+ <td>dilute brown DBA</td>
+ <td>5</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>31</td>
+ <td>R4466LU.CEL</td>
+ <td>R4466LU</td>
+ <td>BXD70</td>
+ <td>M</td>
+ <td>75</td>
+ <td>dilute brown DBA</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>32</td>
+ <td>R4467LU.CEL</td>
+ <td>R4467LU</td>
+ <td>BXD71</td>
+ <td>M</td>
+ <td>64</td>
+ <td>dilute brown DBA</td>
+ <td>4</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>33</td>
+ <td>R4468LU.CEL</td>
+ <td>R4468LU</td>
+ <td>BXD73</td>
+ <td>M</td>
+ <td>59</td>
+ <td>dilute brown DBA</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>34</td>
+ <td>R4469L.CEL</td>
+ <td>R4469LU</td>
+ <td>BXD75</td>
+ <td>M</td>
+ <td>51</td>
+ <td>dilute brown DBA</td>
+ <td>4</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>35</td>
+ <td>R4470L.CEL</td>
+ <td>R4470LU</td>
+ <td>BXD2</td>
+ <td>M</td>
+ <td>84</td>
+ <td>black</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>36</td>
+ <td>R4471H-re.CEL</td>
+ <td>R4471LU</td>
+ <td>BXD83</td>
+ <td>M</td>
+ <td>75</td>
+ <td>dilute brown DBA</td>
+ <td>2</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>37</td>
+ <td>R4472L.CEL</td>
+ <td>R4472LU</td>
+ <td>BXD84</td>
+ <td>M</td>
+ <td>78</td>
+ <td>dilute brown DBA</td>
+ <td>2</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>38</td>
+ <td>R4473LU.CEL</td>
+ <td>R4473LU</td>
+ <td>BXD86</td>
+ <td>M</td>
+ <td>77</td>
+ <td>black</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>39</td>
+ <td>R4474LU.CEL</td>
+ <td>R4474LU</td>
+ <td>BXD87</td>
+ <td>M</td>
+ <td>67</td>
+ <td>black</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>40</td>
+ <td>R4475LU.CEL</td>
+ <td>R4475LU</td>
+ <td>BXD9</td>
+ <td>M</td>
+ <td>78</td>
+ <td>dilute brown DBA</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>41</td>
+ <td>R4476LU.CEL</td>
+ <td>R4476LU</td>
+ <td>BXD90</td>
+ <td>M</td>
+ <td>63</td>
+ <td>dilute brown DBA</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>42</td>
+ <td>R4477LU.CEL</td>
+ <td>R4477LU</td>
+ <td>BXD65</td>
+ <td>M</td>
+ <td>59</td>
+ <td>brown</td>
+ <td>3</td>
+ <td>ORNL</td>
+ </tr>
+ <tr>
+ <td>43</td>
+ <td>R4478LU.CEL</td>
+ <td>R4478LU</td>
+ <td>BXD6</td>
+ <td>M</td>
+ <td>92</td>
+ <td>gray</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>44</td>
+ <td>R4479LU.CEL</td>
+ <td>R4479LU</td>
+ <td>BXD96</td>
+ <td>M</td>
+ <td>71</td>
+ <td>black</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>45</td>
+ <td>R4480LU.CEL</td>
+ <td>R4480LU</td>
+ <td>BXD97</td>
+ <td>M</td>
+ <td>80</td>
+ <td>brown</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>46</td>
+ <td>R4481LU.CEL</td>
+ <td>R4481LU</td>
+ <td>BXD98</td>
+ <td>M</td>
+ <td>80</td>
+ <td>dilute brown DBA</td>
+ <td>2</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>47</td>
+ <td>R4482LU.CEL</td>
+ <td>R4482LU</td>
+ <td>BXD99</td>
+ <td>M</td>
+ <td>72</td>
+ <td>dilute brown DBA</td>
+ <td>2</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>48</td>
+ <td>R4483LU.CEL</td>
+ <td>R4483LU</td>
+ <td>BXD22</td>
+ <td>M</td>
+ <td>66</td>
+ <td>gray</td>
+ <td>2</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>49</td>
+ <td>R4484LU.CEL</td>
+ <td>R4484LU</td>
+ <td>BXD25</td>
+ <td>M</td>
+ <td>54</td>
+ <td>brown</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>50</td>
+ <td>R4485LU.CEL</td>
+ <td>R4485LU</td>
+ <td>B6D2F1</td>
+ <td>M</td>
+ <td>62</td>
+ <td>black</td>
+ <td>5</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>51</td>
+ <td>R4486LU.CEL</td>
+ <td>R4486LU</td>
+ <td>B6D2F1</td>
+ <td>F</td>
+ <td>70</td>
+ <td>black</td>
+ <td>2</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>52</td>
+ <td>R4487LU.CEL</td>
+ <td>R4487LU</td>
+ <td>BALB/cByJ</td>
+ <td>F</td>
+ <td>91</td>
+ <td>white</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>53</td>
+ <td>R4488LU.CEL</td>
+ <td>R4488LU</td>
+ <td>BALB/cByJ</td>
+ <td>M</td>
+ <td>91</td>
+ <td>white</td>
+ <td>2</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>54</td>
+ <td>R4489LU.CEL</td>
+ <td>R4489LU</td>
+ <td>D2B6F1</td>
+ <td>F</td>
+ <td>61</td>
+ <td>black</td>
+ <td>2</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>55</td>
+ <td>R4490LU.CEL</td>
+ <td>R4490LU</td>
+ <td>D2B6F1</td>
+ <td>M</td>
+ <td>61</td>
+ <td>black</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>56</td>
+ <td>R4491LU.CEL</td>
+ <td>R4491LU</td>
+ <td>FVB/NJ</td>
+ <td>F</td>
+ <td>62</td>
+ <td>white</td>
+ <td>5</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>57</td>
+ <td>R4492LU.CEL</td>
+ <td>R4492LU</td>
+ <td>FVB/NJ</td>
+ <td>M</td>
+ <td>73</td>
+ <td>white</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>58</td>
+ <td>R4493LU.CEL</td>
+ <td>R4493LU</td>
+ <td>WSB/EiJ</td>
+ <td>F</td>
+ <td>76</td>
+ <td>agouti</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>59</td>
+ <td>R4494LU.CEL</td>
+ <td>R4494LU</td>
+ <td>WSB/EiJ</td>
+ <td>M</td>
+ <td>76</td>
+ <td>agouti</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>60</td>
+ <td>R4495LU.CEL</td>
+ <td>R4495LU</td>
+ <td>C57BL/6J</td>
+ <td>F</td>
+ <td>65</td>
+ <td>black</td>
+ <td>3</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>61</td>
+ <td>R4496LU.CEL</td>
+ <td>R4496LU</td>
+ <td>C57BL/6J</td>
+ <td>M</td>
+ <td>65</td>
+ <td>black</td>
+ <td>2</td>
+ <td>UTM RW</td>
+ </tr>
+ <tr>
+ <td>62</td>
+ <td>R4497LU.CEL</td>
+ <td>R4497LU</td>
+ <td>129X1/SvJ</td>
+ <td>F</td>
+ <td>65</td>
+ <td>white</td>
+ <td>4</td>
+ <td>JAX</td>
+ </tr>
+ <tr>
+ <td>63</td>
+ <td>R4498LU.CEL</td>
+ <td>R4498LU</td>
+ <td>129X1/SvJ</td>
+ <td>M</td>
+ <td>66</td>
+ <td>white</td>
+ <td>4</td>
+ <td>JAX</td>
+ </tr>
+ <tr>
+ <td>64</td>
+ <td>R4499LU.CEL</td>
+ <td>R4499LU</td>
+ <td>DBA/2J</td>
+ <td>F</td>
+ <td>65</td>
+ <td>dilute brown DBA</td>
+ <td>3</td>
+ <td>ORNL</td>
+ </tr>
+ <tr>
+ <td>65</td>
+ <td>R4500LU.CEL</td>
+ <td>R4500LU</td>
+ <td>DBA/2J</td>
+ <td>M</td>
+ <td>59</td>
+ <td>dilute brown DBA</td>
+ <td>2</td>
+ <td>JAX</td>
+ </tr>
+ <tr>
+ <td>66</td>
+ <td>R4501LU.CEL</td>
+ <td>R4501LU</td>
+ <td>LP/J</td>
+ <td>F</td>
+ <td>65</td>
+ <td>agouti</td>
+ <td>4</td>
+ <td>JAX</td>
+ </tr>
+ <tr>
+ <td>67</td>
+ <td>R4502LU.CEL</td>
+ <td>R4502LU</td>
+ <td>LP/J</td>
+ <td>M</td>
+ <td>65</td>
+ <td>agouti</td>
+ <td>4</td>
+ <td>JAX</td>
+ </tr>
+ <tr>
+ <td>68</td>
+ <td>R4503LU.CEL</td>
+ <td>R4503LU</td>
+ <td>SJL/J</td>
+ <td>F</td>
+ <td>63</td>
+ <td>white</td>
+ <td>4</td>
+ <td>JAX</td>
+ </tr>
+ <tr>
+ <td>69</td>
+ <td>R4504LU.CEL</td>
+ <td>R4504LU</td>
+ <td>SJL/J</td>
+ <td>M</td>
+ <td>65</td>
+ <td>white</td>
+ <td>4</td>
+ <td>JAX</td>
+ </tr>
+ </tbody>
+ </table>
+ </td>
+ </tr>
+ </tbody>
+</table>
+</blockquote>
diff --git a/general/datasets/Hzi_0408_m/summary.rtf b/general/datasets/Hzi_0408_m/summary.rtf
new file mode 100644
index 0000000..5d3c1a7
--- /dev/null
+++ b/general/datasets/Hzi_0408_m/summary.rtf
@@ -0,0 +1,37 @@
+<p>Phase I of BXD lung transcriptome mapping project. Project organized by Drs. Robert Williams, Klaus Schughart, Lu Lu. Started November 29, 2008. There are total 70 samples in phase I including 50 BXD strains and 10 paired inbred strains.</p>
+
+<p><a abstractlink="yes" alsec="jour" alterm="Respir Res." aria-expanded="false" aria-haspopup="true" href="https://www.ncbi.nlm.nih.gov/pubmed/21535883#" role="menuitem" title="Respiratory research.">Respir Res.</a>&nbsp;2011 May 2;12:61. doi: 10.1186/1465-9921-12-61.</p>
+
+<p><b>Genome-wide analysis of the mouse&nbsp;lung&nbsp;transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures.</b></p>
+
+<p><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Alberts%20R%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=21535883">Alberts R</a>1,&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Lu%20L%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=21535883">Lu L</a>,&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Williams%20RW%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=21535883">Williams RW</a>,&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Schughart%20K%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=21535883">Schughart K</a>.</p>
+
+<h3><a aria-expanded="false" href="https://www.ncbi.nlm.nih.gov/pubmed/21535883#" id="ui-ncbitoggler-2" role="button" title="Open/close author information list">Author information</a></h3>
+
+<h3>Erratum in</h3>
+
+<ul>
+ <li>Respir Res. 2012;13(1):5.&nbsp;</li>
+</ul>
+
+<h3>Abstract</h3>
+
+<h4>BACKGROUND:&nbsp;</h4>
+
+<p>The&nbsp;lung&nbsp;is critical in surveillance and initial defense against pathogens. In humans, as in mice, individual genetic differences strongly modulate pulmonary responses to infectious agents, severity of&nbsp;lung&nbsp;disease, and potential allergic reactions. In a first step towards understanding genetic predisposition and pulmonary molecular networks that underlie individual differences in disease vulnerability, we performed a global analysis of normative&nbsp;lung&nbsp;gene expression levels in inbred mouse strains and a large family of BXD strains that are widely used for systems genetics. Our goal is to provide a key community resource on the genetics of the normative&nbsp;lungtranscriptome that can serve as a foundation for experimental analysis and allow predicting genetic predisposition and response to pathogens, allergens, and xenobiotics.</p>
+
+<h4>METHODS:&nbsp;</h4>
+
+<p>Steady-state polyA+ mRNA levels were assayed across a diverse and fully genotyped panel of 57 isogenic strains using the Affymetrix M430 2.0 array. Correlations of expression levels between genes were determined. Global expression QTL (eQTL) analysis and network covariance analysis was performed using tools and resources in GeneNetwork http://www.genenetwork.org.</p>
+
+<h4>RESULTS:&nbsp;</h4>
+
+<p>Expression values were highly variable across strains and in many cases exhibited a high heritability factor. Several genes which showed a restricted expression to&nbsp;lung&nbsp;tissue were identified. Using correlations between gene expression values across all strains, we defined and extended memberships of several important molecular networks in the&nbsp;lung. Furthermore, we were able to extract signatures of immune cell subpopulations and characterize co-variation and shared genetic modulation. Known QTL regions for respiratory infection susceptibility were investigated and several cis-eQTL genes were identified. Numerous cis- and trans-regulated transcripts and chromosomal intervals with strong regulatory activity were mapped. The Cyp1a1 P450 transcript had a strong trans-acting eQTL (LOD 11.8) on Chr 12 at 36 &plusmn; 1 Mb. This interval contains the transcription factor Ahr that has a critical mis-sense allele in the DBA/2J haplotype and evidently modulates transcriptional activation by AhR.</p>
+
+<h4>CONCLUSIONS:&nbsp;</h4>
+
+<p>Large-scale gene expression analyses in genetic reference populations revealed&nbsp;lung-specific and immune-cell gene expression profiles and suggested specific gene regulatory interactions.</p>
+
+<dl>
+ <dt>PMID:21535883&nbsp;PMCID:<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105947/" ref="aid_type=pmcid">PMC3105947</a>&nbsp;DOI:<a href="https://dx.doi.org/10.1186/1465-9921-12-61" ref="aid_type=doi">10.1186/1465-9921-12-61</a></dt>
+</dl>
generated by cgit v1.2.3 (git 2.44.0) at 2024-11-25 07:02:42 +0000