path: root/gn3/db/traits.py

"""This class contains functions relating to trait data manipulation"""
import os
from functools import reduce
from typing import Any, Dict, Union, Sequence

import MySQLdb

from gn3.settings import TMPDIR
from gn3.random import random_string
from gn3.function_helpers import compose
from gn3.db.datasets import retrieve_trait_dataset


def export_trait_data(
        trait_data: dict, samplelist: Sequence[str], dtype: str = "val",
        var_exists: bool = False, n_exists: bool = False):
    """
    Export data according to `samplelist`. Mostly used in calculating
    correlations.

    DESCRIPTION:
    Migrated from
    https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/base/webqtlTrait.py#L166-L211

    PARAMETERS
    trait: (dict)
      The dictionary of key-value pairs representing a trait
    samplelist: (list)
      A list of sample names
    dtype: (str)
      ... verify what this is ...
    var_exists: (bool)
      A flag indicating existence of variance
    n_exists: (bool)
      A flag indicating existence of ndata
    """
    def __export_all_types(tdata, sample):
        sample_data = []
        if tdata[sample]["value"]:
            sample_data.append(tdata[sample]["value"])
            if var_exists:
                if tdata[sample]["variance"]:
                    sample_data.append(tdata[sample]["variance"])
                else:
                    sample_data.append(None)
            if n_exists:
                if tdata[sample]["ndata"]:
                    sample_data.append(tdata[sample]["ndata"])
                else:
                    sample_data.append(None)
        else:
            if var_exists and n_exists:
                sample_data += [None, None, None]
            elif var_exists or n_exists:
                sample_data += [None, None]
            else:
                sample_data.append(None)

        return tuple(sample_data)

    def __exporter(accumulator, sample):
        # pylint: disable=[R0911]
        if sample in trait_data["data"]:
            if dtype == "val":
                return accumulator + (trait_data["data"][sample]["value"], )
            if dtype == "var":
                return accumulator + (trait_data["data"][sample]["variance"], )
            if dtype == "N":
                return accumulator + (trait_data["data"][sample]["ndata"], )
            if dtype == "all":
                return accumulator + __export_all_types(trait_data["data"], sample)
            raise KeyError(f"Type `{dtype}` is incorrect")
        if var_exists and n_exists:
            return accumulator + (None, None, None)
        if var_exists or n_exists:
            return accumulator + (None, None)
        return accumulator + (None,)

    return reduce(__exporter, samplelist, tuple())


def get_trait_csv_sample_data(conn: Any,
                              trait_name: int, phenotype_id: int) -> str:
    """Fetch a trait and return it as a csv string"""
    __query = ("SELECT concat(st.Name, ',', ifnull(pd.value, 'x'), ',', "
               "ifnull(ps.error, 'x'), ',', ifnull(ns.count, 'x')) as 'Data' "
               ",ifnull(ca.Name, 'x') as 'CaseAttr', "
               "ifnull(cxref.value, 'x') as 'Value' "
               "FROM PublishFreeze pf "
               "JOIN PublishXRef px ON px.InbredSetId = pf.InbredSetId "
               "JOIN PublishData pd ON pd.Id = px.DataId "
               "JOIN Strain st ON pd.StrainId = st.Id "
               "LEFT JOIN PublishSE ps ON ps.DataId = pd.Id "
               "AND ps.StrainId = pd.StrainId "
               "LEFT JOIN NStrain ns ON ns.DataId = pd.Id "
               "AND ns.StrainId = pd.StrainId "
               "LEFT JOIN CaseAttributeXRefNew cxref ON "
               "(cxref.InbredSetId = px.InbredSetId AND "
               "cxref.StrainId = st.Id) "
               "LEFT JOIN CaseAttribute ca ON ca.Id = cxref.CaseAttributeId "
               "WHERE px.Id = %s AND px.PhenotypeId = %s ORDER BY st.Name")
    case_attr_columns = set()
    csv_data = {}
    with conn.cursor() as cursor:
        cursor.execute(__query, (trait_name, phenotype_id))
        for data in cursor.fetchall():
            if data[1] == "x":
                csv_data[data[0]] = None
            else:
                sample, case_attr, value = data[0], data[1], data[2]
                if not csv_data.get(sample):
                    csv_data[sample] = {}
                csv_data[sample][case_attr] = None if value == "x" else value
                case_attr_columns.add(case_attr)
        if not case_attr_columns:
            return ("Strain Name,Value,SE,Count\n" +
                    "\n".join(csv_data.keys()))
        else:
            columns = sorted(case_attr_columns)
            csv = ("Strain Name,Value,SE,Count," +
                   ",".join(columns) + "\n")
            for key, value in csv_data.items():
                if not value:
                    csv += (key + (len(case_attr_columns) * ",x") + "\n")
                else:
                    vals = [str(value.get(column, "x")) for column in columns]
                    csv += (key + "," + ",".join(vals) + "\n")
            return csv
    return "No Sample Data Found"


def update_sample_data(conn: Any,  # pylint: disable=[R0913]
                       trait_name: str,
                       strain_name: str,
                       phenotype_id: int,
                       value: Union[int, float, str],
                       error: Union[int, float, str],
                       count: Union[int, str]):
    """Given the right parameters, update sample-data from the relevant
    table."""
    strain_id, data_id = "", ""

    with conn.cursor() as cursor:
        cursor.execute(
            ("SELECT Strain.Id, PublishData.Id FROM "
             "(PublishData, Strain, PublishXRef, PublishFreeze) "
             "LEFT JOIN PublishSE ON "
             "(PublishSE.DataId = PublishData.Id AND "
             "PublishSE.StrainId = PublishData.StrainId) "
             "LEFT JOIN NStrain ON "
             "(NStrain.DataId = PublishData.Id AND "
             "NStrain.StrainId = PublishData.StrainId) "
             "WHERE PublishXRef.InbredSetId = "
             "PublishFreeze.InbredSetId AND "
             "PublishData.Id = PublishXRef.DataId AND "
             "PublishXRef.Id = %s AND "
             "PublishXRef.PhenotypeId = %s "
             "AND PublishData.StrainId = Strain.Id "
             "AND Strain.Name = %s"),
            (trait_name, phenotype_id, str(strain_name)))
        strain_id, data_id = cursor.fetchone()
    updated_published_data: int = 0
    updated_se_data: int = 0
    updated_n_strains: int = 0

    with conn.cursor() as cursor:
        # Update the PublishData table
        if value == "x":
            cursor.execute(("DELETE FROM PublishData "
                            "WHERE StrainId = %s AND Id = %s"),
                           (strain_id, data_id))
            updated_published_data = cursor.rowcount
        else:
            cursor.execute(("UPDATE PublishData SET value = %s "
                        "WHERE StrainId = %s AND Id = %s"),
                       (value, strain_id, data_id))
            updated_published_data = cursor.rowcount

            if not updated_published_data:
                cursor.execute(
                    ("SELECT * FROM "
                     "PublishData WHERE StrainId = "
                     "%s AND Id = %s"),
                    (strain_id, data_id))
                if not cursor.fetchone():
                    cursor.execute(("INSERT INTO PublishData (Id, StrainId, "
                                    " value) VALUES (%s, %s, %s)"),
                                   (data_id, strain_id, value))
                    updated_published_data = cursor.rowcount

        # Update the PublishSE table
        if error == "x":
            cursor.execute(("DELETE FROM PublishSE "
                            "WHERE StrainId = %s AND DataId = %s"),
                           (strain_id, data_id))
            updated_se_data = cursor.rowcount
        else:
            cursor.execute(("UPDATE PublishSE SET error = %s "
                            "WHERE StrainId = %s AND DataId = %s"),
                           (None if error == "x" else error,
                            strain_id, data_id))
            updated_se_data = cursor.rowcount
            if not updated_se_data:
                cursor.execute(
                    ("SELECT * FROM "
                     "PublishSE WHERE StrainId = "
                     "%s AND DataId = %s"),
                    (strain_id, data_id))
                if not cursor.fetchone():
                    cursor.execute(
                        ("INSERT INTO PublishSE (StrainId, DataId, "
                         " error) VALUES (%s, %s, %s)"),
                        (strain_id, data_id, None if error == "x" else error))
                    updated_se_data = cursor.rowcount

        # Update the NStrain table
        if count == "x":
            cursor.execute(("DELETE FROM NStrain "
                            "WHERE StrainId = %s AND DataId = %s"),
                           (strain_id, data_id))
            updated_n_strains = cursor.rowcount
        else:
            cursor.execute(("UPDATE NStrain SET count = %s "
                            "WHERE StrainId = %s AND DataId = %s"),
                           (count, strain_id, data_id))
            updated_n_strains = cursor.rowcount
            if not updated_n_strains:
                cursor.execute(
                    ("SELECT * FROM "
                     "NStrain WHERE StrainId = "
                     "%s AND DataId = %s"),
                    (strain_id, data_id))
                if not cursor.fetchone():
                    cursor.execute(("INSERT INTO NStrain "
                                    "(StrainId, DataId, count) "
                                    "VALUES (%s, %s, %s)"),
                                   (strain_id, data_id, count))
                    updated_n_strains = cursor.rowcount
    return (updated_published_data,
            updated_se_data, updated_n_strains)


def delete_sample_data(conn: Any,
                       trait_name: str,
                       strain_name: str,
                       phenotype_id: int):
    """Given the right parameters, delete sample-data from the relevant
    table."""
    strain_id, data_id = "", ""

    deleted_published_data: int = 0
    deleted_se_data: int = 0
    deleted_n_strains: int = 0

    with conn.cursor() as cursor:
        # Delete the PublishData table
        try:
            cursor.execute(
                ("SELECT Strain.Id, PublishData.Id FROM "
                 "(PublishData, Strain, PublishXRef, PublishFreeze) "
                 "LEFT JOIN PublishSE ON "
                 "(PublishSE.DataId = PublishData.Id AND "
                 "PublishSE.StrainId = PublishData.StrainId) "
                 "LEFT JOIN NStrain ON "
                 "(NStrain.DataId = PublishData.Id AND "
                 "NStrain.StrainId = PublishData.StrainId) "
                 "WHERE PublishXRef.InbredSetId = "
                 "PublishFreeze.InbredSetId AND "
                 "PublishData.Id = PublishXRef.DataId AND "
                 "PublishXRef.Id = %s AND "
                 "PublishXRef.PhenotypeId = %s "
                 "AND PublishData.StrainId = Strain.Id "
                 "AND Strain.Name = %s"),
                (trait_name, phenotype_id, str(strain_name)))

            # Check if it exists if the data was already deleted:
            if _result := cursor.fetchone():
                strain_id, data_id = _result

            # Only run if the strain_id and data_id exist
            if strain_id and data_id:
                cursor.execute(("DELETE FROM PublishData "
                                "WHERE StrainId = %s AND Id = %s"),
                               (strain_id, data_id))
                deleted_published_data = cursor.rowcount

                # Delete the PublishSE table
                cursor.execute(("DELETE FROM PublishSE "
                                "WHERE StrainId = %s AND DataId = %s"),
                               (strain_id, data_id))
                deleted_se_data = cursor.rowcount

                # Delete the NStrain table
                cursor.execute(("DELETE FROM NStrain "
                                "WHERE StrainId = %s AND DataId = %s"),
                               (strain_id, data_id))
                deleted_n_strains = cursor.rowcount
        except Exception as e:  #pylint: disable=[C0103, W0612]
            conn.rollback()
            raise MySQLdb.Error
        conn.commit()
        cursor.close()
        cursor.close()

    return (deleted_published_data,
            deleted_se_data, deleted_n_strains)


def insert_sample_data(conn: Any,  # pylint: disable=[R0913]
                       trait_name: str,
                       strain_name: str,
                       phenotype_id: int,
                       value: Union[int, float, str],
                       error: Union[int, float, str],
                       count: Union[int, str]):
    """Given the right parameters, insert sample-data to the relevant table.

    """

    inserted_published_data, inserted_se_data, inserted_n_strains = 0, 0, 0
    with conn.cursor() as cursor:
        try:
            cursor.execute("SELECT DataId FROM PublishXRef WHERE Id = %s AND "
                           "PhenotypeId = %s", (trait_name, phenotype_id))
            data_id = cursor.fetchone()

            cursor.execute("SELECT Id FROM Strain WHERE Name = %s",
                           (strain_name,))
            strain_id = cursor.fetchone()

            # Return early if an insert already exists!
            cursor.execute("SELECT Id FROM PublishData where Id = %s "
                           "AND StrainId = %s",
                           (data_id, strain_id))
            if cursor.fetchone():  # This strain already exists
                return (0, 0, 0)

            # Insert the PublishData table
            cursor.execute(("INSERT INTO PublishData (Id, StrainId, value)"
                            "VALUES (%s, %s, %s)"),
                           (data_id, strain_id, value))
            inserted_published_data = cursor.rowcount

            # Insert into the PublishSE table if error is specified
            if error and error != "x":
                cursor.execute(("INSERT INTO PublishSE (StrainId, DataId, "
                                " error) VALUES (%s, %s, %s)"),
                               (strain_id, data_id, error))
            inserted_se_data = cursor.rowcount

            # Insert into the NStrain table
            if count and count != "x":
                cursor.execute(("INSERT INTO NStrain "
                                "(StrainId, DataId, count) "
                                "VALUES (%s, %s, %s)"),
                               (strain_id, data_id, count))
            inserted_n_strains = cursor.rowcount
        except Exception:  # pylint: disable=[C0103, W0612]
            conn.rollback()
            raise MySQLdb.Error
    return (inserted_published_data,
            inserted_se_data, inserted_n_strains)


def retrieve_publish_trait_info(trait_data_source: Dict[str, Any], conn: Any):
    """Retrieve trait information for type `Publish` traits.

    https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/base/webqtlTrait.py#L399-L421"""
    keys = (
        "Id", "PubMed_ID", "Pre_publication_description",
        "Post_publication_description", "Original_description",
        "Pre_publication_abbreviation", "Post_publication_abbreviation",
        "Lab_code", "Submitter", "Owner", "Authorized_Users", "Authors",
        "Title", "Abstract", "Journal", "Volume", "Pages", "Month", "Year",
        "Sequence", "Units", "comments")
    columns = (
        "PublishXRef.Id, Publication.PubMed_ID, "
        "Phenotype.Pre_publication_description, "
        "Phenotype.Post_publication_description, "
        "Phenotype.Original_description, "
        "Phenotype.Pre_publication_abbreviation, "
        "Phenotype.Post_publication_abbreviation, "
        "Phenotype.Lab_code, Phenotype.Submitter, Phenotype.Owner, "
        "Phenotype.Authorized_Users, CAST(Publication.Authors AS BINARY), "
        "Publication.Title, Publication.Abstract, Publication.Journal, "
        "Publication.Volume, Publication.Pages, Publication.Month, "
        "Publication.Year, PublishXRef.Sequence, Phenotype.Units, "
        "PublishXRef.comments")
    query = (
        "SELECT "
        f"{columns} "
        "FROM "
        "PublishXRef, Publication, Phenotype "
        "WHERE "
        "PublishXRef.Id = %(trait_name)s AND "
        "Phenotype.Id = PublishXRef.PhenotypeId AND "
        "Publication.Id = PublishXRef.PublicationId AND "
        "PublishXRef.InbredSetId = %(trait_dataset_id)s")
    with conn.cursor() as cursor:
        cursor.execute(
            query,
            {
                k: v for k, v in trait_data_source.items()
                if k in ["trait_name", "trait_dataset_id"]
            })
        return dict(zip([k.lower() for k in keys], cursor.fetchone()))


def set_confidential_field(trait_type, trait_info):
    """Post processing function for 'Publish' trait types.

    It sets the value for the 'confidential' key."""
    if trait_type == "Publish":
        return {
            **trait_info,
            "confidential": 1 if (
                trait_info.get("pre_publication_description", None)
                and not trait_info.get("pubmed_id", None)) else 0}
    return trait_info


def retrieve_probeset_trait_info(trait_data_source: Dict[str, Any], conn: Any):
    """Retrieve trait information for type `ProbeSet` traits.

    https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/base/webqtlTrait.py#L424-L435"""
    keys = (
        "name", "symbol", "description", "probe_target_description", "chr",
        "mb", "alias", "geneid", "genbankid", "unigeneid", "omim",
        "refseq_transcriptid", "blatseq", "targetseq", "chipid", "comments",
        "strand_probe", "strand_gene", "probe_set_target_region", "proteinid",
        "probe_set_specificity", "probe_set_blat_score",
        "probe_set_blat_mb_start", "probe_set_blat_mb_end", "probe_set_strand",
        "probe_set_note_by_rw", "flag")
    columns = (f"ProbeSet.{x}" for x in keys)
    query = (
        f"SELECT {', '.join(columns)} "
        "FROM "
        "ProbeSet, ProbeSetFreeze, ProbeSetXRef "
        "WHERE "
        "ProbeSetXRef.ProbeSetFreezeId = ProbeSetFreeze.Id AND "
        "ProbeSetXRef.ProbeSetId = ProbeSet.Id AND "
        "ProbeSetFreeze.Name = %(trait_dataset_name)s AND "
        "ProbeSet.Name = %(trait_name)s")
    with conn.cursor() as cursor:
        cursor.execute(
            query,
            {
                k: v for k, v in trait_data_source.items()
                if k in ["trait_name", "trait_dataset_name"]
            })
        return dict(zip(keys, cursor.fetchone()))


def retrieve_geno_trait_info(trait_data_source: Dict[str, Any], conn: Any):
    """Retrieve trait information for type `Geno` traits.

    https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/base/webqtlTrait.py#L438-L449"""
    keys = ("name", "chr", "mb", "source2", "sequence")
    columns = ", ".join(f"Geno.{x}" for x in keys)
    query = (
        f"SELECT {columns} "
        "FROM "
        "Geno INNER JOIN GenoXRef ON GenoXRef.GenoId = Geno.Id "
        "INNER JOIN GenoFreeze ON GenoFreeze.Id = GenoXRef.GenoFreezeId "
        "WHERE "
        "GenoFreeze.Name = %(trait_dataset_name)s AND "
        "Geno.Name = %(trait_name)s")
    with conn.cursor() as cursor:
        cursor.execute(
            query,
            {
                k: v for k, v in trait_data_source.items()
                if k in ["trait_name", "trait_dataset_name"]
            })
        return dict(zip(keys, cursor.fetchone()))


def retrieve_temp_trait_info(trait_data_source: Dict[str, Any], conn: Any):
    """Retrieve trait information for type `Temp` traits.

    https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/base/webqtlTrait.py#L450-452"""
    keys = ("name", "description")
    query = (
        f"SELECT {', '.join(keys)} FROM Temp "
        "WHERE Name = %(trait_name)s")
    with conn.cursor() as cursor:
        cursor.execute(
            query,
            {
                k: v for k, v in trait_data_source.items()
                if k in ["trait_name"]
            })
        return dict(zip(keys, cursor.fetchone()))


def set_haveinfo_field(trait_info):
    """
    Common postprocessing function for all trait types.

    Sets the value for the 'haveinfo' field."""
    return {**trait_info, "haveinfo": 1 if trait_info else 0}


def set_homologene_id_field_probeset(trait_info, conn):
    """
    Postprocessing function for 'ProbeSet' traits.

    Sets the value for the 'homologene' key.
    """
    query = (
        "SELECT HomologeneId FROM Homologene, Species, InbredSet"
        " WHERE Homologene.GeneId = %(geneid)s AND InbredSet.Name = %(group)s"
        " AND InbredSet.SpeciesId = Species.Id AND"
        " Species.TaxonomyId = Homologene.TaxonomyId")
    with conn.cursor() as cursor:
        cursor.execute(
            query,
            {
                k: v for k, v in trait_info.items()
                if k in ["geneid", "group"]
            })
        res = cursor.fetchone()
        if res:
            return {**trait_info, "homologeneid": res[0]}
    return {**trait_info, "homologeneid": None}


def set_homologene_id_field(trait_type, trait_info, conn):
    """
    Common postprocessing function for all trait types.

    Sets the value for the 'homologene' key."""
    def set_to_null(ti): return {**ti, "homologeneid": None} # pylint: disable=[C0103, C0321]
    functions_table = {
        "Temp": set_to_null,
        "Geno": set_to_null,
        "Publish": set_to_null,
        "ProbeSet": lambda ti: set_homologene_id_field_probeset(ti, conn)
    }
    return functions_table[trait_type](trait_info)


def load_publish_qtl_info(trait_info, conn):
    """
    Load extra QTL information for `Publish` traits
    """
    query = (
        "SELECT PublishXRef.Locus, PublishXRef.LRS, PublishXRef.additive "
        "FROM PublishXRef, PublishFreeze "
        "WHERE PublishXRef.Id = %(trait_name)s "
        "AND PublishXRef.InbredSetId = PublishFreeze.InbredSetId "
        "AND PublishFreeze.Id = %(dataset_id)s")
    with conn.cursor() as cursor:
        cursor.execute(
            query,
            {
                "trait_name": trait_info["trait_name"],
                "dataset_id": trait_info["db"]["dataset_id"]
            })
        return dict(zip(["locus", "lrs", "additive"], cursor.fetchone()))
    return {"locus": "", "lrs": "", "additive": ""}


def load_probeset_qtl_info(trait_info, conn):
    """
    Load extra QTL information for `ProbeSet` traits
    """
    query = (
        "SELECT ProbeSetXRef.Locus, ProbeSetXRef.LRS, ProbeSetXRef.pValue, "
        "ProbeSetXRef.mean, ProbeSetXRef.additive "
        "FROM ProbeSetXRef, ProbeSet "
        "WHERE ProbeSetXRef.ProbeSetId = ProbeSet.Id "
        " AND ProbeSet.Name = %(trait_name)s "
        "AND ProbeSetXRef.ProbeSetFreezeId = %(dataset_id)s")
    with conn.cursor() as cursor:
        cursor.execute(
            query,
            {
                "trait_name": trait_info["trait_name"],
                "dataset_id": trait_info["db"]["dataset_id"]
            })
        return dict(zip(
            ["locus", "lrs", "pvalue", "mean", "additive"], cursor.fetchone()))
    return {"locus": "", "lrs": "", "pvalue": "", "mean": "", "additive": ""}


def load_qtl_info(qtl, trait_type, trait_info, conn):
    """
    Load extra QTL information for traits

    DESCRIPTION:
    Migrated from
    https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/base/webqtlTrait.py#L500-L534

    PARAMETERS:
    qtl: boolean
    trait_type: string
      The type of the trait in consideration
    trait_info: map/dictionary
      A dictionary of the trait's key-value pairs
    conn:
      A database connection object
    """
    if not qtl:
        return trait_info
    qtl_info_functions = {
        "Publish": load_publish_qtl_info,
        "ProbeSet": load_probeset_qtl_info
    }
    if trait_info["name"] not in qtl_info_functions:
        return trait_info

    return qtl_info_functions[trait_type](trait_info, conn)


def build_trait_name(trait_fullname):
    """
    Initialises the trait's name, and other values from the search data provided
    """
    def dataset_type(dset_name):
        if dset_name.find('Temp') >= 0:
            return "Temp"
        if dset_name.find('Geno') >= 0:
            return "Geno"
        if dset_name.find('Publish') >= 0:
            return "Publish"
        return "ProbeSet"

    name_parts = trait_fullname.split("::")
    assert len(name_parts) >= 2, f"Name format error: '{trait_fullname}'"
    dataset_name = name_parts[0]
    dataset_type = dataset_type(dataset_name)
    return {
        "db": {
            "dataset_name": dataset_name,
            "dataset_type": dataset_type},
        "trait_fullname": trait_fullname,
        "trait_name": name_parts[1],
        "cellid": name_parts[2] if len(name_parts) == 3 else ""
    }


def retrieve_probeset_sequence(trait, conn):
    """
    Retrieve a 'ProbeSet' trait's sequence information
    """
    query = (
        "SELECT ProbeSet.BlatSeq "
        "FROM ProbeSet, ProbeSetFreeze, ProbeSetXRef "
        "WHERE ProbeSet.Id=ProbeSetXRef.ProbeSetId "
        "AND ProbeSetFreeze.Id = ProbeSetXRef.ProbeSetFreezeId "
        "AND ProbeSet.Name = %(trait_name)s "
        "AND ProbeSetFreeze.Name = %(dataset_name)s")
    with conn.cursor() as cursor:
        cursor.execute(
            query,
            {
                "trait_name": trait["trait_name"],
                "dataset_name": trait["db"]["dataset_name"]
            })
        seq = cursor.fetchone()
        return {**trait, "sequence": seq[0] if seq else ""}


def retrieve_trait_info(
        threshold: int, trait_full_name: str, conn: Any,
        qtl=None):
    """Retrieves the trait information.

    https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/base/webqtlTrait.py#L397-L456

    This function, or the dependent functions, might be incomplete as they are
    currently."""
    trait = build_trait_name(trait_full_name)
    trait_dataset_type = trait["db"]["dataset_type"]
    trait_info_function_table = {
        "Publish": retrieve_publish_trait_info,
        "ProbeSet": retrieve_probeset_trait_info,
        "Geno": retrieve_geno_trait_info,
        "Temp": retrieve_temp_trait_info
    }

    common_post_processing_fn = compose(
        lambda ti: load_qtl_info(qtl, trait_dataset_type, ti, conn),
        lambda ti: set_homologene_id_field(trait_dataset_type, ti, conn),
        lambda ti: {"trait_type": trait_dataset_type, **ti},
        lambda ti: {**trait, **ti})

    trait_post_processing_functions_table = {
        "Publish": compose(
            lambda ti: set_confidential_field(trait_dataset_type, ti),
            common_post_processing_fn),
        "ProbeSet": compose(
            lambda ti: retrieve_probeset_sequence(ti, conn),
            common_post_processing_fn),
        "Geno": common_post_processing_fn,
        "Temp": common_post_processing_fn
    }

    retrieve_info = compose(
        set_haveinfo_field, trait_info_function_table[trait_dataset_type])

    trait_dataset = retrieve_trait_dataset(
        trait_dataset_type, trait, threshold, conn)
    trait_info = retrieve_info(
        {
            "trait_name": trait["trait_name"],
            "trait_dataset_id": trait_dataset["dataset_id"],
            "trait_dataset_name": trait_dataset["dataset_name"]
        },
        conn)
    if trait_info["haveinfo"]:
        return {
            **trait_post_processing_functions_table[trait_dataset_type](
                {**trait_info, "group": trait_dataset["group"]}),
            "db": {**trait["db"], **trait_dataset}
        }
    return trait_info


def retrieve_temp_trait_data(trait_info: dict, conn: Any):
    """
    Retrieve trait data for `Temp` traits.
    """
    query = (
        "SELECT "
        "Strain.Name, TempData.value, TempData.SE, TempData.NStrain, "
        "TempData.Id "
        "FROM TempData, Temp, Strain "
        "WHERE TempData.StrainId = Strain.Id "
        "AND TempData.Id = Temp.DataId "
        "AND Temp.name = %(trait_name)s "
        "ORDER BY Strain.Name")
    with conn.cursor() as cursor:
        cursor.execute(
            query,
            {"trait_name": trait_info["trait_name"]})
        return [dict(zip(
            ["sample_name", "value", "se_error", "nstrain", "id"],
            row))
                for row in cursor.fetchall()]
    return []


def retrieve_species_id(group, conn: Any):
    """
    Retrieve a species id given the Group value
    """
    with conn.cursor as cursor:
        cursor.execute(
            "SELECT SpeciesId from InbredSet WHERE Name = %(group)s",
            {"group": group})
        return cursor.fetchone()[0]
    return None


def retrieve_geno_trait_data(trait_info: Dict, conn: Any):
    """
    Retrieve trait data for `Geno` traits.
    """
    query = (
        "SELECT Strain.Name, GenoData.value, GenoSE.error, GenoData.Id "
        "FROM (GenoData, GenoFreeze, Strain, Geno, GenoXRef) "
        "LEFT JOIN GenoSE ON "
        "(GenoSE.DataId = GenoData.Id AND GenoSE.StrainId = GenoData.StrainId) "
        "WHERE Geno.SpeciesId = %(species_id)s "
        "AND Geno.Name = %(trait_name)s AND GenoXRef.GenoId = Geno.Id "
        "AND GenoXRef.GenoFreezeId = GenoFreeze.Id "
        "AND GenoFreeze.Name = %(dataset_name)s "
        "AND GenoXRef.DataId = GenoData.Id "
        "AND GenoData.StrainId = Strain.Id "
        "ORDER BY Strain.Name")
    with conn.cursor() as cursor:
        cursor.execute(
            query,
            {"trait_name": trait_info["trait_name"],
             "dataset_name": trait_info["db"]["dataset_name"],
             "species_id": retrieve_species_id(
                 trait_info["db"]["group"], conn)})
        return [
            dict(zip(
                ["sample_name", "value", "se_error", "id"],
                row))
            for row in cursor.fetchall()]
    return []


def retrieve_publish_trait_data(trait_info: Dict, conn: Any):
    """
    Retrieve trait data for `Publish` traits.
    """
    query = (
        "SELECT "
        "Strain.Name, PublishData.value, PublishSE.error, NStrain.count, "
        "PublishData.Id "
        "FROM (PublishData, Strain, PublishXRef) "
        "LEFT JOIN PublishSE ON "
        "(PublishSE.DataId = PublishData.Id "
        "AND PublishSE.StrainId = PublishData.StrainId) "
        "LEFT JOIN NStrain ON "
        "(NStrain.DataId = PublishData.Id "
        "AND NStrain.StrainId = PublishData.StrainId) "
        "WHERE PublishData.Id = PublishXRef.DataId "
        "AND PublishXRef.Id = %(trait_name)s "
        "AND PublishXRef.InbredSetId = %(dataset_id)s "
        "AND PublishData.StrainId = Strain.Id "
        "ORDER BY Strain.Name")
    with conn.cursor() as cursor:
        cursor.execute(
            query,
            {"trait_name": trait_info["trait_name"],
             "dataset_id": trait_info["db"]["dataset_id"]})
        return [
            dict(zip(
                ["sample_name", "value", "se_error", "nstrain", "id"], row))
            for row in cursor.fetchall()]
    return []


def retrieve_cellid_trait_data(trait_info: Dict, conn: Any):
    """
    Retrieve trait data for `Probe Data` types.
    """
    query = (
        "SELECT "
        "Strain.Name, ProbeData.value, ProbeSE.error, ProbeData.Id "
        "FROM (ProbeData, ProbeFreeze, ProbeSetFreeze, ProbeXRef, Strain,"
        " Probe, ProbeSet) "
        "LEFT JOIN ProbeSE ON "
        "(ProbeSE.DataId = ProbeData.Id "
        " AND ProbeSE.StrainId = ProbeData.StrainId) "
        "WHERE Probe.Name = %(cellid)s "
        "AND ProbeSet.Name = %(trait_name)s "
        "AND Probe.ProbeSetId = ProbeSet.Id "
        "AND ProbeXRef.ProbeId = Probe.Id "
        "AND ProbeXRef.ProbeFreezeId = ProbeFreeze.Id "
        "AND ProbeSetFreeze.ProbeFreezeId = ProbeFreeze.Id "
        "AND ProbeSetFreeze.Name = %(dataset_name)s "
        "AND ProbeXRef.DataId = ProbeData.Id "
        "AND ProbeData.StrainId = Strain.Id "
        "ORDER BY Strain.Name")
    with conn.cursor() as cursor:
        cursor.execute(
            query,
            {"cellid": trait_info["cellid"],
             "trait_name": trait_info["trait_name"],
             "dataset_id": trait_info["db"]["dataset_id"]})
        return [
            dict(zip(
                ["sample_name", "value", "se_error", "id"], row))
            for row in cursor.fetchall()]
    return []


def retrieve_probeset_trait_data(trait_info: Dict, conn: Any):
    """
    Retrieve trait data for `ProbeSet` traits.
    """
    query = (
        "SELECT Strain.Name, ProbeSetData.value, ProbeSetSE.error, "
        "ProbeSetData.Id "
        "FROM (ProbeSetData, ProbeSetFreeze, Strain, ProbeSet, ProbeSetXRef) "
        "LEFT JOIN ProbeSetSE ON "
        "(ProbeSetSE.DataId = ProbeSetData.Id "
        "AND ProbeSetSE.StrainId = ProbeSetData.StrainId) "
        "WHERE ProbeSet.Name = %(trait_name)s "
        "AND ProbeSetXRef.ProbeSetId = ProbeSet.Id "
        "AND ProbeSetXRef.ProbeSetFreezeId = ProbeSetFreeze.Id "
        "AND ProbeSetFreeze.Name = %(dataset_name)s "
        "AND ProbeSetXRef.DataId = ProbeSetData.Id "
        "AND ProbeSetData.StrainId = Strain.Id "
        "ORDER BY Strain.Name")

    with conn.cursor() as cursor:
        cursor.execute(
            query,
            {"trait_name": trait_info["trait_name"],
             "dataset_name": trait_info["db"]["dataset_name"]})
        return [
            dict(zip(
                ["sample_name", "value", "se_error", "id"], row))
            for row in cursor.fetchall()]
    return []


def with_samplelist_data_setup(samplelist: Sequence[str]):
    """
    Build function that computes the trait data from provided list of samples.

    PARAMETERS
    samplelist: (list)
      A list of sample names

    RETURNS:
      Returns a function that given some data from the database, computes the
      sample's value, variance and ndata values, only if the sample is present
      in the provided `samplelist` variable.
    """
    def setup_fn(tdata):
        if tdata["sample_name"] in samplelist:
            val = tdata["value"]
            if val is not None:
                return {
                    "sample_name": tdata["sample_name"],
                    "value": val,
                    "variance": tdata["se_error"],
                    "ndata": tdata.get("nstrain", None)
                }
        return None
    return setup_fn


def without_samplelist_data_setup():
    """
    Build function that computes the trait data.

    RETURNS:
      Returns a function that given some data from the database, computes the
      sample's value, variance and ndata values.
    """
    def setup_fn(tdata):
        val = tdata["value"]
        if val is not None:
            return {
                "sample_name": tdata["sample_name"],
                "value": val,
                "variance": tdata["se_error"],
                "ndata": tdata.get("nstrain", None)
            }
        return None
    return setup_fn


def retrieve_trait_data(trait: dict, conn: Any, samplelist: Sequence[str] = tuple()):
    """
    Retrieve trait data

    DESCRIPTION
    Retrieve trait data as is done in
    https://github.com/genenetwork/genenetwork1/blob/master/web/webqtl/base/webqtlTrait.py#L258-L386
    """
    # I do not like this section, but it retains the flow in the old codebase
    if trait["db"]["dataset_type"] == "Temp":
        results = retrieve_temp_trait_data(trait, conn)
    elif trait["db"]["dataset_type"] == "Publish":
        results = retrieve_publish_trait_data(trait, conn)
    elif trait["cellid"]:
        results = retrieve_cellid_trait_data(trait, conn)
    elif trait["db"]["dataset_type"] == "ProbeSet":
        results = retrieve_probeset_trait_data(trait, conn)
    else:
        results = retrieve_geno_trait_data(trait, conn)

    if results:
        # do something with mysqlid
        mysqlid = results[0]["id"]
        if samplelist:
            data = [
                item for item in
                map(with_samplelist_data_setup(samplelist), results)
                if item is not None]
        else:
            data = [
                item for item in
                map(without_samplelist_data_setup(), results)
                if item is not None]

        return {
            "mysqlid": mysqlid,
            "data": dict(map(
                lambda x: (
                    x["sample_name"],
                    {k: v for k, v in x.items() if x != "sample_name"}),
                data))}
    return {}


def generate_traits_filename(base_path: str = TMPDIR):
    """Generate a unique filename for use with generated traits files."""
    return (
        f"{os.path.abspath(base_path)}/traits_test_file_{random_string(10)}.txt")


def export_informative(trait_data: dict, inc_var: bool = False) -> tuple:
    """
    Export informative strain

    This is a migration of the `exportInformative` function in
    web/webqtl/base/webqtlTrait.py module in GeneNetwork1.

    There is a chance that the original implementation has a bug, especially
    dealing with the `inc_var` value. It the `inc_var` value is meant to control
    the inclusion of the `variance` value, then the current implementation, and
    that one in GN1 have a bug.
    """
    def __exporter__(acc, data_item):
        if not inc_var or data_item["variance"] is not None:
            return (
                acc[0] + (data_item["sample_name"],),
                acc[1] + (data_item["value"],),
                acc[2] + (data_item["variance"],))
        return acc
    return reduce(
        __exporter__,
        filter(lambda td: td["value"] is not None,
               trait_data["data"].values()),
        (tuple(), tuple(), tuple()))